Miscellaneous Flashcards
What are the three types of Tailor’s Bunion?
Type A - large head
Type B - meta-diaphyseal flare or deviation
Type C - enlarged 4-5 IM angle
What’s the IFCC value range of good HbA1c control?
Between 48-58 mmol/mol
What’s a normal HbA1c?
Below 42 mmol/mol
Why is the HbA1c test unreliable in people with anaemia or sickle-cell disease, and Vitamin B12 or folate deficiency?
Because the RBC lifespan may be shortened (due to premature RBC death) or prolonged, thereby affecting the time available for glycosylation to occur, leading to under- or overestimation, respectively.
What is the alternative test for HbA1c?
Fructosamine test
What is the fructosamine test?
A measurement of the glycation of serum protein (albumin). Because albumin has a half-life of 20 days, the fructosamine concentration reflects recent (2-3 week) changes in blood glucose
What is CRP?
C-reaction protein is an acute-phase reactant (protein) that is released into the blood at the start of inflammation or infection or after tissue injury
What’s the physiologic role of CRP?
To complement (enhance) phagocytosis to clear microbes and damaged cells
What’s a normal CRP?
< 5 mg/L
What does ESR measure?
Erythrocyte sedimentation rate is a measure of chronic inflammation
How does ESR work?
The physics of how blood settles has to do with the zeta potential between the red cells. The zeta potential is the normal, negative force that exists between red cells and pushes them apart from each other. Things that disrupt the zeta potential make it easier for the red cells to come close to each other, and thus the cells settle faster in the tube (and ESR goes up). Things that increase the zeta potential between the red cells (making them more repellant than usual) will cause the red cells to settle at a slower rate.
Increased blood levels of certain protein molecules (e.g. fibrinogen or immunoglobulins, which are increased in inflammation) get in between red cells and disrupt (decrease) the zeta potential between the red cells, making them settle at a faster rate in the ESR test.
Recite the podiatrists’ exemption (POMS) list
- Amoxicillin
- Amorolfine hydrochloride cream
- Amorolfine hydrochloride lacquer
- Co-Codamol
- Co-dydramol 10/500
- Codeine
- Erythromycin
- Flucloxacillin
- Silver Sulfadiazine
- Tioconazole
- Topical hydrocortisone
- Bupivacaine
- Ropivacaine
- Lignocaine
- Mepivacaine
- Prilocaine
- Adrenaline
- Methylprednisolone
What is Allopurinol and how does it work?
Anti-gout medication. Inhibits xanthise oxidase - a major enzyme in uric acid synthesis
How does colchicine work?
Acts by interfering with WBC’s ability to phagocytose urate crystals, thus reducing inflammation
What are radiographic findings of gout?
- Periarticular swelling
- Cloud sign - tophaceous material at joint margins
- Rat-bite punched out erosions