Miscellaneous Flashcards
Interactions, literature
1
Q
Drug-Drug Interactions
A
- Addition - combined effect of two drugs equals the sum of the effects of each drug taken alone
- Antagonism - one drug works against the action of another
- Potentiation - one drug increases or prolongs the effect of the other, the total effect is greater than the sum of the effects of each (e.g. Vistaril and Demerol)
- Synergism - joint action of drugs in which their combined effect is more intense or longer than the sum of effects
2
Q
Drug-Disease Interactions
A
- Various disease may inhibit the absorption, metabolism and elimination of different drugs (e.g decongestants may increase blood pressure for patients with hypertension or diabetes)
3
Q
Drug-Nutrient Interactions
A
- Poor nutrition may affect the metabolism of various drugs (e.g. Warfarin and vitamin K)
4
Q
Drug-Food Interactions
A
- Improved absorption with a fatty meal
- Ketoconazole
- Nitrofurantoin
- Griseofulvin
- Decreased absorption with food
- Tetracycline
- Ciprofloxacin
- Etidronate
- Phenytoin
- Norfloxacin
- Zidorudine
- Levothyroxine
- Didanosine
- Grapefruit affects drugs metabolized by cytochrome P450
- Calcium channel blockers
- Estrogens
- Cyclosporine
- Midazolam
- Triazolam
- Warfarin interacts with vitamin K which is in romaine lettuce and spinach
5
Q
Drug-Related Problems
A
- An event/situation that actually/potentially inteferes with optimum outcome, including untreated indication, improper drug selection, subtherapeutic dosage, failure to receive a drug, overdosage, drug use without indication
6
Q
Drug Information Sources
A
- Primary - original reports of scientific, clinical, tehnical, and administrative research projects
- Secondary - general reference books based on primary sources, including abstracting and bibliographic services and specialized microfiche systems
- Tertiary - condensed works based on primary sources, including monographs and textbooks
7
Q
American Hospital Formulary Service Drug Information
A
- Provides information on uses, interactions, pharmacokinetics, dosage, and administration of commercial and experimental drugs
8
Q
Drug Topics Red Book
A
- Source of information concerning prices
- Sections for emergency information, clinical reference guide, practice management, professional development, pharmacy and healthcare organizations, drug reimbursement, manufacturer/wholesale information, product identification, prescription product listing, OTC and non-drug products, and complementary and herbal products
- Necessary for third party reimbursement
9
Q
Goodman and Gilman’s The Pharmacological Basis of Therapeutics
A
- Examines the principles of pharmacokinetics as they relate to medications
10
Q
FDA: Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book)
A
- Approved drugs for use in the US
11
Q
Drug Facts and Comparisons
A
- Provides information with regard to brand and generic names, orphan and investigationa drugs, drug monographs, drug identifcation, dosage calculations
- Updated monthly
12
Q
Handbook on Injectable Drugs
A
- References the compatibility of various parenteral drugs
13
Q
Handbook of Nonprescription Drugs
A
- OTC reference book
14
Q
Martindale: The complete Drug Reference
A
- International reference book on medications
15
Q
Merck Index
A
- Source of chemical substance data