Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hard Stuff > Miscellaneous > Flashcards

Miscellaneous Flashcards

1
Q

Cyclophosphamide - Mechanism of action and Adverse effects

A
  • Alkylating agent - causes cross-linking in DNA
  • Haemorrhagic cystitis, myelosuppression, transitional cell carcinoma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Bleomycin - Mechanism of action and Adverse effects

A
  • Degrades preformed DNA
  • Lung fibrosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Anthracyclines (e.g doxorubicin) - Mechanism of action and Adverse effects

A
  • Stabilizes DNA-topoisomerase II complex inhibits DNA & RNA synthesis
  • Cardiomyopathy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Methotrexate - Mechanism of action and Adverse effects

A
  • Inhibits dihydrofolate reductase and thymidylate synthesis
  • Lung Fibrosis, Liver Fibrosis, Mucositis, Myelosuppression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Fluorouracil (5-FU) - Mechanism of action and Adverse effects

A
  • Pyrimidine analogue inducing cell cycle arrest and apoptosis by blocking thymidylate synthase (works during S phase)
  • Myelosuppression, mucositis, dermatitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

6-mercaptopurine - Mechanism of action and Adverse effects

A
  • Purine analogue that is activated by HGPRTase, decreasing purine synthesis
  • Myelosuppression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Cytarabine - Mechanism of action and Adverse effects

A
  • Pyrimidine antagonist. Interferes with DNA synthesis specifically at the S-phase of the cell cycle and inhibits DNA polymerase
  • Myelosuppression, ataxia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Vincristine, vinblastine - Mechanism of action and Adverse effects

A
  • Inhibits formation of microtubules
  • Vincristine: Peripheral neuropathy (reversible) , paralytic ileus
    Vinblastine: myelosuppression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Docetaxel - Mechanism of action and Adverse effects

A
  • Prevents microtubule depolymerisation & disassembly, decreasing free tubulin
  • Neutropaenia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Irinotecan - Mechanism of action and Adverse effects

A
  • Inhibits topoisomerase I which prevents relaxation of supercoiled DNA
  • Myelosuppression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cisplatin - Mechanism of action and Adverse effects

A
  • Causes cross-linking in DNA
  • Ototoxicity, peripheral neuropathy, hypomagnesaemia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Hydroxyurea (hydroxycarbamide) - Mechanism of action and Adverse effects

A
  • Inhibits ribonucleotide reductase, decreasing DNA synthesis
  • Myelosuppression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly

Hard Stuff (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions