Miscellaneous

Question 1

What is needed to help paracetamol poisoning? What does it do?

Answer 1

1. Start N-acetylcystine.
2. Increases reactive intermediate to stable metabolite conversion.
3. Increases glutathione transferase activity.

Question 2

What does N-acetylcystine correct in paracetamol overdose?

Answer 2

1. Coagulation defects
   
   • Fluid electrolyte and acid base balance
   • Renal failure
   • Hypoglycaemia
   • Encephalopathy

Question 3

What are some paracetamol induced liver failure poor prognosis indicators?

Answer 3

1. Late presentation
2. Acidosis
3. Prothrommbin time > 70 sec
4. Serum creatinine ≥ 300 µmol/l
5. Consider emergency liver transplant - otherwise 80% mortality

Question 4

WHAT IS KAPOSI’S SARCOMA CAUSED BY?

Answer 4

HHV-8 = human herpes virus 8