Miscallaneous Flashcards
1
Q
Asparaginase
A
Hydrolyzes serum asparagine, depriving tumor cells of the asparagine necessary for protein synthesis, leading to cell death.
2
Q
Hydroxyurea
A
inhibits ribonucleotide reductase and leads to depletion of deoynuceloside triphosphate pools. DNA synthesis is thereby inhibited. Kills cells in S phase and is given orally.
3
Q
Interferon-alpha
A
approved for hairy cell leukemia, CML, malignant melanoma, and Kaposi’s sarcoma (endothelial tumor caused by HHV-8 virus.
