Minimize Adverse Effects & Myelosuppression

Question 1

5HT3 receptor blocker & NK-1 inhibitors

Answer 1

Emesis associated with Chemotherapy

Question 2

Leucovorin

Answer 2

Meylosuppression associated with Methotrexate (rescues bone marrow)

Question 3

Mesna

Answer 3

Reduces hemorrhagic cystitis cause by Cyclophosphamide

Question 4

Amifostine

Answer 4

reduces renal toxicity associated with Cisplatin

Question 5

Dexrazoxane

Answer 5

reduces Anthracycline-induced cardiotoxicity

Question 6

Filgrastim & Sargramostim

Answer 6

neutropenia

Question 7

Drugs the cause HIGH Myelosuppression

Answer 7

1. Vinblastine
2. Doxorubicin
3. Daunorubicin
4. Cytarabine
5. Alkylating Agents (Cyclophosphamide, Busulfan, Decarbizine, Procarbizine)

Question 8

Drugs that cause MEDIUM meylosuppression

Answer 8

1. 5-Fu
2. Methotrexate
3. Carboplatin

Question 9

Drugs that cause LOW myelosuppression

Answer 9

1. Bleomycin
2. Vincristine
3. Asparaginase

Question 10

P-Glycoprotein

Answer 10

Doxorubicine, Daunorubicine, Etoposide, Tenoposide, Vincristine, Vinblastine