misc from hall

Question 1

which IV drug changes from water soluble to lipid soluble when enterting the bloodstream

Answer 1

midazolam

Question 2

max submucosal epi dose

Answer 2

if using halothane 2.1 mics/kg
if using mac 1.2 sev/iso 5mics/kg

Question 3

termination of norepi occurs primarily through what mechanism

Answer 3

reuptake by postgang nerve endings (update 1)

Question 4

waht abx potentiate NMB agents

Answer 4

aminoglycosides + clindamycin + lincomycin

Question 5

explain dibucaine test

Answer 5

dibucaine can inhibit the normal psuedocholinesterase and normal numner is 70s

heterozygous for atyptical enzyme is 50-60 with 20 min block

homo for atypical is 20-30 w 1-2 hour block

Question 6

what drugs can trigger acute intermittent porphyria

Answer 6

etomidate
barbituates

Question 7

how will SSRI affect cytp 450

Answer 7

inhibits that enzyme

Question 8

what is fentanyl have shorter duration of action and quicker onset than morphine

Answer 8

fent is more lipid soluble to crosses the BBB quickly and then redistributes to peripheral tissues quickly (shorter duration of action)

Question 9

side effects of cyclosporin

Answer 9

seizures, renal roxicity, pareastheias, gum hyperplasia, hirutiusm, high BG, hirutism

Question 10

why is succ contracindicated in routine trach intubations in kids

Answer 10

hyperkalemia can cause death in subclinical cases of duchenes

Question 11

neuromuscular blocking agent effect is terminated by what mechanism?

Answer 11

diffusion from the junction back into the plasma

Question 12

what opioid can not be reversed by naloxone

Answer 12

buprenophine bc it has a way longer half life

Question 13

what enzyme change will cause rapid metaolism of succ

Answer 13

C5

Question 14

how does cimetidine affect cyp p450

Answer 14

binds to the enzyme and inhibits it

Question 15

what actylcholinesterase inhibitor can be used to treat post op shivering

Answer 15

physostigmine

Question 16

tricyclic antidepressants may cause exagerated response to what drug given in the OR

Answer 16

ephedrine
becsuse u have increased NE at nerve endings

Question 17

what volatile agent has the highest mac for neonate (age 1-30 days age group0

Answer 17

sevo

the others have infants 1 months to 6 months having the highest mac

Question 18

why is the rise of Fa:Fi steep over the first couple seconds

Answer 18

minimal anesthetic uptake by pulm vasculature

Question 19

what does n20 do to HR

Answer 19

mild increase in HR leading to mildly increased CO

only CV effect it has

Question 20

why would des cause a transient increase in HR and BP

Answer 20

perhaps becuase airway irritaiton causes transient sympathetic rxn

Question 21

vessel rich group receives what percent of cardiac output

Answer 21

75%

Question 22

at what age do humans ahve the highest anesthetiuc requirement (mac)

Answer 22

neonates > adults > infants

esxcepf for sevo its most 1-6 months of age

Question 23

what is normal tracheal capillary presure

Answer 23

25-30

Question 24

what gas is solluble in rubber and plastic compoennts

Answer 24

halothane
iso

think “ISOlate” in rubber and plastic

Question 25

what ratio reflects time constant

Answer 25

brain/blood partician coefficient

Question 26

whats the primary toxic effect of bupi on CV

Answer 26

delay of ventricular depolarization