misc from hall Flashcards
which IV drug changes from water soluble to lipid soluble when enterting the bloodstream
midazolam
max submucosal epi dose
if using halothane 2.1 mics/kg
if using mac 1.2 sev/iso 5mics/kg
termination of norepi occurs primarily through what mechanism
reuptake by postgang nerve endings (update 1)
waht abx potentiate NMB agents
aminoglycosides + clindamycin + lincomycin
explain dibucaine test
dibucaine can inhibit the normal psuedocholinesterase and normal numner is 70s
heterozygous for atyptical enzyme is 50-60 with 20 min block
homo for atypical is 20-30 w 1-2 hour block
what drugs can trigger acute intermittent porphyria
etomidate
barbituates
how will SSRI affect cytp 450
inhibits that enzyme
what is fentanyl have shorter duration of action and quicker onset than morphine
fent is more lipid soluble to crosses the BBB quickly and then redistributes to peripheral tissues quickly (shorter duration of action)
side effects of cyclosporin
seizures, renal roxicity, pareastheias, gum hyperplasia, hirutiusm, high BG, hirutism
why is succ contracindicated in routine trach intubations in kids
hyperkalemia can cause death in subclinical cases of duchenes
neuromuscular blocking agent effect is terminated by what mechanism?
diffusion from the junction back into the plasma
what opioid can not be reversed by naloxone
buprenophine bc it has a way longer half life
what enzyme change will cause rapid metaolism of succ
C5
how does cimetidine affect cyp p450
binds to the enzyme and inhibits it
what actylcholinesterase inhibitor can be used to treat post op shivering
physostigmine
tricyclic antidepressants may cause exagerated response to what drug given in the OR
ephedrine
becsuse u have increased NE at nerve endings
what volatile agent has the highest mac for neonate (age 1-30 days age group0
sevo
the others have infants 1 months to 6 months having the highest mac
why is the rise of Fa:Fi steep over the first couple seconds
minimal anesthetic uptake by pulm vasculature
what does n20 do to HR
mild increase in HR leading to mildly increased CO
only CV effect it has
why would des cause a transient increase in HR and BP
perhaps becuase airway irritaiton causes transient sympathetic rxn
vessel rich group receives what percent of cardiac output
75%
at what age do humans ahve the highest anesthetiuc requirement (mac)
neonates > adults > infants
esxcepf for sevo its most 1-6 months of age
what is normal tracheal capillary presure
25-30
what gas is solluble in rubber and plastic compoennts
halothane
iso
think “ISOlate” in rubber and plastic
what ratio reflects time constant
brain/blood partician coefficient
whats the primary toxic effect of bupi on CV
delay of ventricular depolarization
