Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Infectious Disease > MISC. Abx > Flashcards

MISC. Abx Flashcards

1
Q

Fluoroquinolones Drugs

A

Ciprofolxacin* (Cipro)
Levofloxacin* (Levaquin)
Moxifloxacin* (Avelox)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Fluoroquinolones

A

Bactericidal with good distribution into most tissues and fluids except the CNS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Fluoroquinolones MOA

A

Inhibit the ability of the bacterial DNA to replicate.

Inhibit DNA gyrase and topoisomerase IV necessary for replication of bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Fluoroquinolones Spectrum of activity

A

Bug: Pseudomonas Aeruginosa
Drug: ciprofloxacin and levofloxacin

Bug: Aerobic gram negative
Drug: All fluoroquinolones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

FQ: Black box warning

A

WARNING: Fluoroquinolones, including LEVAQUIN®, are associated with an increased risk of tendinitis and tendon rupture in all ages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

FQ Side effects

A 
Nausea
Diarrhea
Dizziness
Confusion
Tendon rupture
QT prolongation**
Tendonitis
Peripheral neuropathy**
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Sulfonamides

A

Sulfamethoxazole/Trimethoprim (SMX-TMP) (Bactrim DS, Septra)

ORAL ONLY!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Sulfonamides MOA

A

Folic acid synthesis inhibitors

Bacteria need to produce folic acid to survive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Sulfonamides uses

A 
Urinary tract infections (most common)
PCP or P. jiroveci pneumonia
Toxoplasmosis
Gram positive and negative infections
MRSA
NOT USED for Sinusitis and otitis media
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Sulfonamides SE

A 
Rash
Fever
Nausea, vomiting, diarrhea
Stevens-Johnson syndrome
Vasculitis
Hemolytic anemia if underlying G6PD deficiency
thrombocytopenia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Nitrofurantion (Macrobid)

A

ONLY for treatment and prevention of uncomplicated urinary tract infections
PO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Nitrofurantion (Macrobid): Effective against common organisms that cause UTIs

A 
E. Coli
Citrobacter
Staph saprophyticus
Enterococcus faecalis
Eneterococcus faecium

Some emerging resistance against Enterobacter and Kelbsiella

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Nitrofurantion (Macrobid) Side effects

A 
Most common: Nausea and vomiting
Pulmonary reactions (rare)
Hepatic effects (rare)
Peripheral neuropathy in long term use in patients with renal failure
NO SIGNIFICANT DRUG INTERACTIONS
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Metronidazole (Flagyl)

A

Anti-Anerobic
Inhibitor of bacterial protein synthesis.
Good activity against gram positive and negative anaerobes
Oral, IV, and Topical

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Metronidazole (Flagyl) Treatment of choice for

A

Bacterial vaginosis

Trichomoniasis

C. difficile diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Metronidazole (Flagyl) SE

A 
Most common: Nausea, vomiting, abdominal pain and metallic taste 
Seizures (high doses)
Peripheral neuropathy (prolonged courses)
pancreatitis
17
Q

Metronidazole (Flagyl) Drug interactions

A

Enhances anticoagulant effect of warfarin

Alcohol
Flushing, palpitations, nausea, vomiting

Inhibitor of CYP34A so potential for many drug interactions (Phenobarbital, phenytoin, rifampin )

Infectious Disease (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions