MISC Flashcards
1
Q
PEComa
A
mTOR inhibitors = most active, ~41% ORR & median PFS 9mos
Other treatments = letrozole if ER/PR+, targeted based on NGS
2
Q
IHC stains
A
Myogenin- rhabdomyosarcoma Keratin stains - epithelial Desmin & caldesmin - smooth muscle p16 - cervical PAX8- GYN origin CK7- epithelial market Synaptophysin- neuroendocrine CK20- colon CD10- stromal
3
Q
Risk reduction- ovarian cancer BRCA
A
RRSO- decreases ovarian cancer by 80% w/ BRCA mutation
4
Q
What kind of receptor is HER2 (also known as ERBB2)
A
Tyrosine kinase receptor encoded by EGFR2 gene
- upregulation influences cell proliferation, migration, & cell survival
- humanized monoclonal Abs trastuzumab & Pertuzumab FDA approved for use in advanced or recurrent HER2+ endometrial serous (4 month PFS benefit);not recommended for adjuvant tx in early stage disease
- over expression & amplification found in 20-40% uterine serous
