Misc. Flashcards

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1
Q

What is lichen sclerosis? Management?

A
Autoimmune disorder
Elastic tissue turns to collagen
Bruised red, purpuric signs may appear
Vulva gradually becomes white, flat and shiny
Intensely itchy
May be pre-malignany

Mx:
Clobetasol propionate cream (topical steroid)daily for 28 days
then alternate days for 4 weeks, then twice weekly for 8 weeks then as needed

Steroid unresponsive may respond to topical tacrolimus

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2
Q

What is lichen planus? Features? Where do they occur? Management?

A
Lesions on flexor aspects of wrists/forearms/ankles/legs
Purple
Pruritix
Poly-angular
Planar (flat topped
Papiles
Seen at any age + white lacy markings
Lesions elsewhere:
Scalp (Scarring alopecia)
Nails (longitudinal ridges)
Tongue 
Mouth
Genitals

Often arise at site of trauma (Koebner phenomenon)

Mx: Topical steroids ± topical antifungals

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3
Q

What is koebners phenomenon? What conditions is it seen in?

A
Skin lesion which appear at the site of injury
Psoriasis
Warts
Vitiligo
Lichen planus
Lichen sclerosus
Molluscum contagiosum
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4
Q

What is seborrhoeic keratoses? Features? Mx?

A

Benign epidermal skin lesions seen in older people

Large variation in skin colour from flesh to light brown to black
Stuck on appearance
Keratotic plugs may be seen on surface

Reassure
Curretage, cryosurgery, shave biopsy

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5
Q

What is pityriasis rosea? Mx?

A

Acute, self-limiting rash which tends to affect young adults. The aetiology is not fully understood but is thought that herpes hominis virus 7 (HHV-7) may play a role.
Rash is preceded by a herald patch (oval red scaly patch)
It affects the neck, trunk and proximal limbs

Self-limiting 4-12 weeks

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6
Q

How can you differentiate guttate psoriasis from pityriasis rosea?

A

GP - preceded by strep throat infection
PR - recent RTI

GP - tear drop scaly applies on trunk and limbs
PR - herald patch followed 1-2 weeks later by multiple erythematous, slightly raised oval lesions with fine scale confined to the outer aspect of lesions

GP - resolve spontaneously 2-3 m
PR - resolve 6wks

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7
Q

What is port wine stain?

A

Vascular birthmarks that tend to be unilateral
Deep rend or purple
Do not resolve spontaneously
Darken and become raised over time

Treat with cosmetic camouflage or laser therapy

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8
Q

What are strawberry naeevi?

A

Infantile haemanglioma
Rapidly enlarging bright red spot
Most go by 5-7 years
No treatment unless a vital function is impaired.

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9
Q

What are salmon patches?

A

Flat dull red areas found on face or neck

Asymptomatic and removed for cosmetic purposes

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10
Q

What is polymorphic eruption of pregnancy>

A

Pruritic condition associated with last trimester
Lesions often first appear in abdominal striae
Management depends on severity:
Emollients
Mild topical steorids
Oral steroids

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11
Q

What is phemphigoid gestations?

A

Pruritic blistering lesions
Often peri-umbilical later trunk, back, buttocks and arms
Usually 2nd/3rd trimester
Oral corticosteroids

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12
Q

What is a pyogenic granuloma?

A

Vascular lesion thought to arise as a result of minor trauma, typically occurring on fingers
It appears as a fleshy moist red lesion which grows and often bleeds easily

(not granulomas or pyogenic)

Eruptive haemangioma

Caused by trauma, pregnancy

Most common sites are head/neck upper trunk and hands.
Oral mucosa lesions in pregnancy
Initially small brown spot - progresses to red/brown lesions spherical in shape.
Lesions bleed profusely/ulcerate

Curettage, cauterisation, cryotherapy, excision

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13
Q

What are skin causes of pruririts?

A
Eczema
Scabies
Phemigoid eruptions
Asteatotic eczema 
Pityriasis rosea
Psoriasis
Urticaria
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14
Q

What is asteatotic eczema?

A

Affects lower legs with dry eczema that polygonally fissures into a paving pattern
Emollients and soap substitutes help + moderately potent steroid (eumovate) for affected itchy inflamed areas

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15
Q

What are medical causes of pruritus?

A
Liver disease
Iron deficiency anaemia
Lymphoma
Polycythaemia
CKD
Hypo/hyperthyroidism
Diabetes
Pregnancy
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16
Q

What signs of liver disease?

A
Spider naevi
Palmar erythema
Bruising
Gynaecomastia
Ascites
Jaundice
Encephalopathy
17
Q

What signs of IDA?

A

Koilinichia
Atrophic glossitis
Angular stomatitis

18
Q

What signs of polycythaemia?

A

Pruritus after warm bath
Ruddy complexion
Gout
PUD

19
Q

What signs of CKD

A

Oedema and weight gain

HTN

20
Q

What signs of lymphoma

A
Night sweats
Lymphadenopathy
Splenomegaly
Hepatomegaly
Fatigue
21
Q

What is dermatitis herpetiformis? Features, diagnosis and mx?

A

Autoimmune blistering skin disorder associated with coeliac disease
Caused by IgA deposition in the dermis

Features:
Itchy vesicular skin lesions on the extensor surfaces (e.g. elbows, knees, buttocks)

Dx:
Skin biopsy shows IgA deposition in granular pattern in upper dermis

Management:
Gluten free diet
Dapsone

22
Q

Lichen scleross vs lichen planus

A

Planus: purple, pruritic, papular, polygonal rash on flexor surfaces. Wickham’s striae over surface. Oral involvement common
Sclerosus: itchy white spots typically seen on the vulva of elderly women

23
Q

What is hereditary haemorrhage telangiectasia? 4 diagnostic criteria?

A
Autosomal dominant 
Multiple telangiectasia (fill from outside) over the skin and mucous membranes

4 main diagnostic criteria:
Epistaxis - spontaneous recurrent nosebleeds
Telangiectases - multiple at characteristic sites (lips, oral cavity, fingers, nose)
Visceral lesions - GI telangiectasia, with to without bleeding, pulmonary AV malformations
Family Hx - first degree relative