Misc. Flashcards
Down’s AFP
low
Down’s bHCG
high
Downs Nuchal Translucency
Thickened
Down’s Oestradiol
low
Down’s PAPPA
low
You review a 3-year-old girl who is being treated for idiopathic constipation with Movicol Paediatric Plain. Her mother has increased the dose but unfortunately there has been no response. She remains well and examination of the abdomen is normal. What is the most appropriate next step?
Add Senna (Stimulant laxtive)
DDH
Most stabilise 3-6w Pavlik harness (flexion-abduction orthosis) in children younger than 4-5 months
COCP and surgery
stop 4 weeks prior, restart 2 weeks after
Avoid whilst breasfeeding
antibiotics: ciprofloxacin, tetracycline, chloramphenicol, sulphonamides
psychiatric drugs: lithium, benzodiazepines
aspirin
carbimazole
sulphonylureas
cytotoxic drugs
amiodarone
A 2 day old baby born by a ventouse delivery- swelling on the left side of his head in the parietal region. His head appeared normal immediately after delivery. On examination, the baby is well and the swelling does not cross suture lines. The fontanelles and sutures appear normal. What is the most likely diagnosis?
Cephalohaematoma
A 9-day-old pre-term neonate stops tolerating his cow’s milk feeds given by the nurses in the special care baby unit. He vomited after the most recent feed and the nurse noticed bile in the vomit. Stools are normal consistency but the last stool contained fresh red blood. On examination he is well hydrated but his abdomen is grossly distended and an urgent abdominal x-ray is requested. X-ray shows distended loops of bowel with thickening of the bowel wall. What is the next best step in management?
Continue oral feeds, switching to breast milk Commence broad spectrum antibiotics Commence IV fluids Commence IV hydrocortisone Commence erythromycin
Commence broad spectrum antibiotics
This scenario describes a case of necrotising enterocolitis. Given the history and examination along with the age and prematurity of the infant, bacterial necrotising enterocolitis is the most likely diagnosis. Due to the seriousness of this, broad spectrum antibiotics must be commenced immediately. For this reason, answer 2 is the correct answer.
Although necrotising enterocolitis is seen more often in bottle fed infants, changing feeds at this stage is futile.
IV fluids are important to maintain hydration but not as urgently needed in this case as antibiotics.
Erythromycin is given antenatally to prevent necrotising enterocolitis but is not useful in treatment.
Impetigo Treatement
Topical Fusidic Acid
topical retapamulin is used second-line if fusidic acid has been ineffective or is not tolerated
Contraceptives - time until effective (if not first day period):
instant: IUD
2 days: POP
7 days: COC, injection, implant, IUS
A 31-year-old man and 30-year-old woman attend clinic after struggling to conceive for 12 months. Testing reveals mild endometriosis. What is the most appropriate management?
Continue trying to conceive naturally for another 12 months
Pre Eclampsia RF
Aged 40 years or older Nulliparity Pregnancy interval of more than 10 years Family history of pre-eclampsia Previous history of pre-eclampsia Body mass index of 30kg/m^2 or above Pre-existing vascular disease such as hypertension Pre-existing renal disease Multiple pregnancy
Placenta Praevia
5% will have low-lying placenta when scanned at 16-20 weeks gestation
incidence at delivery is only 0.5%, therefore most placentas rise away from cervix
Rescan at 34w
Neuroleptic Malignant Syndrome
more common in young male patients onset usually in first 10 days of treatment or after increasing dose pyrexia rigidity tachycardia
Mx
stop antipsychotic
IV fluids to prevent renal failure
dantrolene* may be useful in selected cases
bromocriptine, dopamine agonist, may also be used
A 72 year-old woman presents to the GP with an itchy, sore white plaque on her vulva. The patient has a past medical history of type 1 diabetes and no personal or family history of cancer. Which of the following is the most likely diagnosis?
Lichen sclerosus
Management
topical steroids and emollients
Contraindications to MMR
severe immunosuppression
allergy to neomycin
children who have received another live vaccine by injection within 4 weeks
pregnancy should be avoided for at least 1 month following vaccination
immunoglobulin therapy within the past 3 months (there may be no immune response to the measles vaccine if antibodies are present)
A 5-year-old girl is seen in the emergency department following her first seizure. lasted 5 minutes. falling to the floor suddenly and jerking her arms. now feels well in herself and does not remember the incident. She is otherwise well.
Neurological examination is normal. General examination reveals four de-pigmented patches of skin over her torso and areas of thickened leathery skin over her lumbar region.
What is the most likely diagnosis?
Tuberous sclerosis
Cutaneous features
depigmented ‘ash-leaf’ spots which fluoresce under UV light
roughened patches of skin over lumbar spine (Shagreen patches)
adenoma sebaceum (angiofibromas): butterfly distribution over nose
fibromata beneath nails (subungual fibromata)
café-au-lait spots* may be seen
Neurological features
developmental delay
epilepsy (infantile spasms or partial)
intellectual impairment
Also
retinal hamartomas: dense white areas on retina (phakomata)
rhabdomyomas of the heart
gliomatous changes can occur in the brain lesions
polycystic kidneys, renal angiomyolipomata
lymphangioleiomyomatosis: multiple lung cysts
A 2-year-old child with a history of atopic eczema is brought to the local GP surgery. Her eczema is usually well controlled with emollients but her parents are concerned as the facial eczema has got significantly worse overnight. She now has painful clustered blisters on both cheeks, around her mouth on her neck. Her temperature is 37.9ºC. What is the most appropriate management?
Admit
Eczema herpeticum is a serious condition that requires IV antivirals
Bishop Score
0 1 2 3
Cervical position Posterior Intermediate Anterior -
Cervical consistency Firm Intermediate Soft -
Cervical effacement 0-30% 40-50% 60-70% 80%
Cervical dilation <1 cm 1-2 cm 3-4 cm >5 cm
Fetal station -3 -2 -1, 0 +1,+2
You are asked to see a 31-year-old woman on the labour ward who has developed a high fever (39.1ºC) 2 days post-partum. She complains of dysuria, and frequency, you suspect a urinary tract infection. She is choosing to breast feed, has severe anaphylactic reactions to penicillins. Which antibiotic would be appropriate?
Nitrofurantoin Trimethoprim Cefaclor (a cephalosporin) Ciprofloxacin Fosfomycin
Trimethoprim is present in milk but is not known to be harmful for short term use. This would be an appropriate choice.
Nitrofurantoin should be avoided when breastfeeding - small amounts in milk but can cause haemolysis in G6PD infants.
Cefaclor is safe to use when breastfeeding but should be avoided in this instance due to history of anaphylaxis with penicillins as cephalosporins have cross-sensitivity with beta-lactams (penicillin).
Ciprofloxacin should be avoided when breast feeding.
Fosfomycin may be used for uncomplicated lower urinary tract infections caused by multiple resistant bacteria when other antibacterials cannot be used, but this is an unlicensed use.
A 7-year-old boy is admitted to your ward after being struck by car.
patient also has type-1 Von Willebrand disease
Which of the following agents can be administered to reduce bleeding while awaiting theatre?
Desmopressin
is a synthetic analogue of vasopressin a.k.a antidiuretic hormone (ADH). It stimulates the release of Von Willebrand factor from Weibel-Palade bodies in endothelial cells.
SSRI Discontinuation symptoms
increased mood change restlessness difficulty sleeping unsteadiness sweating gastrointestinal symptoms: pain, cramping, diarrhoea, vomiting paraesthesia
Which one of the following contraceptives do the Faculty of Sexual and Reproductive Healthcare (FSRH) recommend should be discontinued after the age of 50 years?
Injectable contraceptives (e.g. Depo-Provera)
A 69-year-old man is diagnosed as having Parkinson’s disease. Which one of the following psychiatric problems is most likely to occur in this patient?
Depression
Whilst dementia is common in patients with Parkinson’s disease depression is known to exist in around 40%
Diagnose Hirschsprung’s disease
Rectal Biopsy
A 6-year-old boy weighing 28kg is admitted to the paediatric intensive care unit with severe meningococcal meningitis. Due to his level of consciousness he is intubated and receives ventilation via an endotrachael tube. As he is nil by mouth, the consultant asks you to prescribe his maintenance fluids for the following 24 hours. How much maintenance fluid should he be given over the next 24 hours?
1000 + 500 + 160 = 1660ml
At her booking visit, a woman mentions to her midwife that she has been previously diagnosed with immune thrombocytopenic purpura (ITP). Which procedure carries the greatest risk of haemorrhage in the newborn?
Prolonged ventouse delivery
A 14-year-old male being investigated for iron-deficiency anaemia is found to have numerous polyps in his jejunum. On examination he is also noted to have pigmented lesions on his palms and soles. What is the likely diagnosis?
Peutz-Jeghers syndrome
Genetics
autosomal dominant
responsible gene encodes serine threonine kinase LKB1 or STK11
Features
hamartomatous polyps in GI tract (mainly small bowel)
pigmented lesions on lips, oral mucosa, face, palms and soles
intestinal obstruction e.g. intussusception
gastrointestinal bleeding
Management
conservative unless complications develop