Misc 1 Flashcards
what is commonly seen in primary disorders?
mucosal and skin bleeding (most common epistaxis)
what is ITP?
autoimmune production of IgG against platelet antigens *(i.e. GPIIb/IIIa)
-common cause of thrombocytopenia
chronic ITP is seen in patients ________ and is associated with ________
of childbearing age
lupus
what is commonly seen in secondary disorders?
bleeding into muscles and joints
rebleeding after surgical procedures
Hep increases
PTT (HEP and PTT both have 3 letters)
Coumadin increases
PT
vWD
most common inherited
- -> problems with platelet adhesion
- inc bleeding time (platelet prob) and PTT (binds factor VIII)
abnormal ristocetin test shows
vWF problem - platelets can’t aggregate
Vit K affects which factors
II, VII, IX, X, protein C and S
what does liver failure cause in the coagulation cascade?
coagulation factors are made in the liver
- vit K is activated in the liver
- PT will be affected
what converts plasminogen to plasmin?
tPA
what inhibits plasmin?
alpha2-antiplasmid
what does the endothelium produce that blocks the coagulation cascade?
PGI2, NO
what else blocks the coag cascade?
- tPA -> plasmin
- thrombomodulin
what does plasmin do?
- cleaves fibrin and fibrinogen and coagulation factors
- inhibits platelet aggregation
if you give heparin, what happens to the PTT?
increases
