Hemostasis Defects II Flashcards
PT is prolonged with
Factor II, VII, V, X, fibrinogen deficiencies, vitamin K deficiency, liver disease or patient on warfarin
If protime is more prolonged than PTT:
liver disease, vit K deficiency, warfarin or rat poison
Prolonged PTT indicates:
Hemophilia (deficiency in factor VIII, IX, or XI), acquired hemophilia, severe von Willebrand disease, heparin in sample (an anticoagulant), fibrin split products. Also can indicated Factor XII deficiency or lupus anticoagulant (both non-bleeding disorders).
If PTT is relatively more prolonged than PT:
Disseminated intravascular coagulation (DIC)
Prolonged bleeding time indicates:
vascular disorders (thrombocytopenia, DIC, etc) and von Willebrand Disease–not by other coagulation factors such as haemophilia
_______ and _______ can prolong bleeding time significantly
Aspirin and other cyclooxygenase inhibitors