mirtazapine

Question 1

what is it indicated for

Answer 1

major depression

Question 2

MOA

Answer 2

presynaptic alpha2-adrenoreceptor antagonist which increases central noradrenergic and serotonergic neurotransmission.

Question 3

when to take the dose

Answer 3

bedtime

Question 4

treatment cessation - withdrawal features and how to reduce dose

Answer 4

Nausea, vomiting, dizziness, agitation, anxiety, and headache are most common features of withdrawal if treatment stopped abruptly or if dose reduced markedly; dose should be reduced over several weeks.

Question 5

counsel patients to report the following

Answer 5

Blood Disorders

Patients should be advised to report any fever, sore throat, stomatitis or other signs of infection during treatment. Blood count should be performed and the drug stopped immediately if blood dyscrasia suspected.