antidepressants - TCAs

Question 1

MOA

Answer 1

block reuptake of serotonin and noradrenaline (different drugs to different extents)

Question 1

clomipramine is more selective for which transmission

Answer 1

blocks reuptake of serotinergic

Question 2

imirapmine is more selective for which transmission

Answer 2

noradrenergic transmission

Question 3

TCAs can be roughly divided into those with ..

Answer 3

additional sedative properties
and those that are less sedating

Question 4

Agitated and anxious patients tend to respond best to

Answer 4

sedatives

Question 5

withdrawn and apathetic patients will often obtain most benefit from the

Answer 5

less sedating

Question 6

TCAs with sedative properties

Answer 6

amitriptyline
clompramine
dosulepin
doxepin
mianserin
trazodone (not tca, serotonin-antagonist-and-reuptake-inhibitor)
trimipramine

Question 7

the 3 TCAs with less sedative proprieties

Answer 7

imipramine
lofepramine
nortriptyline

Question 8

This drug has a lower incidence of SE and its less dangerous in OD but is infrequently associated with hepatic toxicity

Answer 8

lofepramine

Question 9

this drug has more marked antimuscarinic side effects than other TCAs

Answer 9

imipramine

Question 10

these two are effective but particularly dangerous in overdosage, and one needs to be initiated by specialist

Answer 10

amitriptyline
dosulepin (specialist)

Question 11

in the elderly, for initial treatment, use. ..

Answer 11

low doses

Question 12

can you use TCAs for treating depression in children

Answer 12

no not effective

Question 13

use of TCAs in elderly is potentially inappropriate STOPP criteria if used for

Answer 13

1st line antidepressant treatment - higher risk of adverse effects than with SSRIs or SNRIs
if prescribed in those with dementia, NAG, cardiac condition abmormality, Hx urinary retention (risk of worsening these)