Miniblock 1 Flashcards
Of the >1400 species of pathogens that can infect humans, zoonoses account for __%
61
Zoonoses account for __% of emerging diseases.
75
Define reservoir
habitat in which an infectious agent normally lives, grows, and multiplies (humans, animals, or the environment)
List and define the different modes/routes of transmission.
Vertical & horizontal(direct(projection & contact) & indirect(vehicle(fomite & common vehicle) & vector (biological & mechanical))
What are the 3 q’s asked when figuring out if something is a reservoir.
- Is it naturally infected with the pathogen?
- Can that species of animal (etc.) maintain the
pathogen over time? - Can this source transmit the disease to a new, susceptible host?
T/F and explain why.
Infection is the same as disease and/or infectivity.
F.
What type of curve will show an exposure followed by waves of secondary and tertiary cases? It is also associated with contagious diseases.
Propagated source
What type of curve will show all animals exposed at once to the same source of infection allowing you to determine a minimum, average, and maximum incubation time?
Common source single point exposure
What type of curve uses animals exposed at different times but to the same source? Incubation period is not clearly shown on this curve.
Common source with intermittent exposure
What are the 3 big factors that affect the shape of an epidemiological curve? Give examples for each.
Host: – immunity or other resistance to disease – direct transmission Agent: – infectiousness of agent – latent and incubation periods – duration of an activity Environment: – especially important for indirect routes of transmission
What are the 4 determinants needed when assessing if an animals is at risk?
Primary, secondary, intrinsic, and extrinsic.
Compare primary to secondary determinant.
Primary is a major contributing factor (usually necessary), as where secondary is a factor that makes the disease more or less likely (predisposing or enabling).
Compare intrinsic to extrinsic determinants.
Intrinsic is internal (age, breed, sex). Extrinsic is outside factors such as housing or medical treatment.
Using bovine shipping fever as an example give a primary and secondary factor for both intrinsic and extrinsic.
IP: immuno naïve animals
IS: young animals
EP: exposure to shipping fever
ES: mixing Cattle
Out of host, agent, and environment which 2 are extrinsic factors? Give examples of each.
Agent:
activity, pathogenicity, the arguments, immunogenicity, mutation rate, resistance
environment:
demographics, climate, housing, crowding/density, diet, stress.
Out of host, agents, and environment which 1 is an intrinsic factor? Give examples.
Host:
age, sex & behavior, genotype, greed, nutrition, and immunity.
What is the idea behind herd immunity?
Infectious diseases can be contained in the population’s resistance to infection is higher enough.
True or false, correct if false: emerging and reemerging diseases are the same thing.
False. Emerging is an unknown disease. A reemerging disease is a disease that was known and was on the decline, but has now become more common.
Name the 5 steps/stages of cross species disease emergence.
- Pathogen exclusive to an animal reservoir
- Animal reservoir transmits to humans/other animals, but no transmission among them
- Animal reservoir transmits to humans/other animals with a few cycles of transmission among them
- Animal reservoir transmits to humans/other animals with sustained transmission among them
- Pathogen exclusive to humans/new animal reservoir
What are the 4 drivers to pathogen emergence?
– land use changes
– food and agricultural system
– human behavior
– environmental systems
What are the 4 major determinants of emergence? Name their subcategories.
Pathogen: – type of agent – mutation/change Reservoir: – phylogenetic distance Transmission: – reservoir size – pathogen prevalence – contact frequency Host: – susceptibility
True or false: the zoonotic pathogens are twice as likely to be associated with emerging diseases.
True
What makes pathogen adaptation and change so dangerous?
It can enhance transmissibility within or between species. Can also allow for evasion of host immunity.
Why is phylogenetic distance between reservoir and new host important?
Pathogens are more likely to cross between closely related species and distant ones. (Best transmission is within the same species)
*pathogens that somehow cross between distantly related species often cause different, often more severe disease.
Why is the new species important to disease emergence?
Because of susceptibility. The animal might be in immuno compromised allowing for easier infection.