Millers etomidate

Question 1

What is the structure of etomidate?

Question 2

What type of structure is etomidate? What is its mechanism of action?

Answer 2

Etomidate is an imidazole derivative. The mechanism by which etomidate exerts its
effects is not completely understood. It appears that etomidate acts in part through
agonist effects at the GABA receptor.

Question 3

What is the induction dose for etomidate? What is the time of onset for the effect of etomidate
subsequent to its administration?

Answer 3

The induction dose of etomidate is 0.3 mg/kg. The administration of etomidate
in induction doses results in unconsciousness in less than 30 seconds. The duration
of action of etomidate after an induction dose is very short, owing to its rapid
clearance from the plasma through redistribution to inactive tissue sites

Question 4

How is etomidate cleared from the plasma?

Answer 4

Etomidate rapidly undergoes nearly complete ester hydrolysis to pharmacologically
inactive metabolites by the liver, with less than 3% of the drug being excreted
in the urine unchanged