miller paper

Question 1

why is it that we typically don’t see as big of an increase in depression in people that are diagnosed with cancer than those diagnosed with heart disease?

Answer 1

cardiac diseases are connected to more inflammation

Question 2

what does chronic stress increase and what does that lead to?

Answer 2

• inflammation

- this leads to heart disease and maybe depression

Question 3

What inflammatory molecules are increases by the chronic stress of caregiving for a relative with dementia?

Answer 3

• cytokines (one of which is interleukin 6)

- c-reactive protein

Question 4

If cortisol inhibits inflammation, and stress increases cortisol, why is chronic stress associated with increased production of inflammatory molecules?

Answer 4

Normally cortisol activates G receptors which alter the transcription which reduces inflammatory molecules like IL-6. But what happens in caregivers is that they have a really weak transcription which gives us a paradoxical result

Question 5

What is elevated in caregivers vs controls and why?

Answer 5

cortisol and IL-6

-some thing about the GR is not working well

Question 6

GR in caregivers vs control

Answer 6

there was no difference in the amount of GR btw caregivers and the control but the activity of GR in the caregivers was reduced

Question 7

What is the paradoxical response in the miller paper?

Answer 7

an increase in IL-6 and cortisol in caregivers

Question 8

What is a common symptom of depression?

Answer 8

dysregulation of cortisol rhythms