Migraine Treatment Flashcards
1
Q
What is the primary class of drugs used in migraine abortive treatment?
A
Triptans
- sumatriptan most commonly used
- sumatriptan and zolmatriptan oral and nasal
- frovatriptan and naratriptan long half life
2
Q
What is the mechanism of action of the triptans?
A
Serotonin 1B/1D agonists CGRP (inhibit release of vasoactive peptides) Vasoconstriction Block brainstem pain pathways Inhibit trigeminal nucleus caudalis
3
Q
Triptan side effects and contraindications
A
Peripheral vasoconstriction
Angina
Dizziness
Flushing
4
Q
Triptan contraindications
A
Stoke/MI
Uncontrolled hypertension/Ischemic heart disease
5
Q
Amitryptaline and Nortryptaline
A
Tricyclic antidepressants used in migraine prophylaxis
6
Q
Divalproex sodium and Valproic acid
A
anti-seizure agents used in migraine prophylaxis
7
Q
Vasoactive agents used in migraine prophylaxis
A
Beta blockers - propranolol, atenolol
Ca channel blockers - verapamil, diltiazem