Migraine Treatment Flashcards

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1
Q

What is the primary class of drugs used in migraine abortive treatment?

A

Triptans

  • sumatriptan most commonly used
  • sumatriptan and zolmatriptan oral and nasal
  • frovatriptan and naratriptan long half life
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2
Q

What is the mechanism of action of the triptans?

A
Serotonin 1B/1D agonists
CGRP (inhibit release of vasoactive peptides)
Vasoconstriction
Block brainstem pain pathways
Inhibit trigeminal nucleus caudalis
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3
Q

Triptan side effects and contraindications

A

Peripheral vasoconstriction
Angina
Dizziness
Flushing

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4
Q

Triptan contraindications

A

Stoke/MI

Uncontrolled hypertension/Ischemic heart disease

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5
Q

Amitryptaline and Nortryptaline

A

Tricyclic antidepressants used in migraine prophylaxis

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6
Q

Divalproex sodium and Valproic acid

A

anti-seizure agents used in migraine prophylaxis

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7
Q

Vasoactive agents used in migraine prophylaxis

A

Beta blockers - propranolol, atenolol

Ca channel blockers - verapamil, diltiazem

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