Mifepristone vs Misoprostol Flashcards
1
Q
What is Mifepristone?
A
A Progesterone Receptor Modulator
2
Q
How does Mifepristone Work?
A
- It blocks progesterone
- It stops the pregnancy from forming
- It causes the placenta and embryo to detach from the uterus
- It causes the cervix to dilate
- It sensitises the Uterus myometrium to prostaglandins so that the myometrium can contract more effectively.
3
Q
How many hours after the ingestion of Mifepristone, is the maximal pharmacological effect?
A
36-48 hours
4
Q
Why do we give Mifepristone?
A
It allows a lower dose of prostaglandin to be used, thus reducing side effects.
5
Q
What is Misoprostol? (GyMiso)
A
It is a synthetic analogue of prostaglandin E1
6
Q
How does Misoprostol work?
A
- It causes the contraction of the uterus.
- This leads to expulsion of the fetus.
- It also causes bleeding and cramps
7
Q
How are Mifepristone and Misoprostol given?
A
They come in a pack.
- First give Mifepristone Line Pharma 200mg tablet.
- Then 36-48 Hours later take GyMiso 800mcgs (4 tablets).
8
Q
What is a Medical Termination of Pregnancy (MTOP) like?
A
It is similar to a miscarriage.
9
Q
What should you make sure you do before you give MS-2 Step and why?
A
An USS
- To confirm gestational age
- To exclude ectopic pregnancy
10
Q
At how many days can MS 2-Step be used?
A
63 days.
