MIDTERMS: Reviewer Flashcards
A 73 year old male has been self-medicating a drug for his insomnia for one month. He
has since missed 2 days of the medication due to his busy schedule. While in a meeting,
he was noted to be irritable, anxious, and most of the time cursed his colleagues. What
condition is the patient experiencing?
A. Cerebrovascular disease
B. Delusion of grandeur
C. Physiologic dependence
D. Psychological dependence
C. Physiologic dependence
A 41 year old female for elective surgery was given IV dose of Thiopental. In 10 seconds
the patient was already sedated. The drug’s rapid effect is most likely attributed to:
A. Drug dose
B. Lipid solubility
C. Route of administration
D. Tolerance
B. Lipid solubility
A 45 year old male with chronic active hepatitis B was prescribed the standard dose of
Zaleplon for his insomnia. The following morning the relative noted difficulty in waking
up the patient. This is most likely caused by this drug’s property:
A. Active metabolite
B. Enzyme activity
C. Impaired hepatic metabolism
D. Short half life
C. Impaired hepatic metabolism
A 32 year old male was prescribed with this drug which has the ability of increasing sleep
time as well as decreasing REM sleep.
A. Eszopiclone
B. Triazolam
C. Zaleplon
D. Zolpidem
A. Eszopiclone
Which first-generation antiseizure medication works by enhancing the effects of GABA
and is often limited by sedation and tolerance issues?
A. Phenytoin
B. Clonazepam
C. Lamotrigine
D. Levetiracetam
B. Clonazepam
Which of the following is a first-generation antiseizure medication commonly used to
treat status epilepticus?
A. Gabapentin
B. Diazepam
C. Lamotrigine
D. Topiramate
B. Diazepam
A 41 year old female was given Thiopental for her elective surgery. The patient was
easily aroused after the surgery. What property of the drug is responsible for this?
A. Hepatic metaboism
B. Lipid solubility
C. Rapid elimination
D. Rapid tissue redistribution
D. Rapid tissue redistribution
A 25 year old male has been taking Zolpidem 1 tab nightly for one month to aid his
insomnia caused by anxiety. He decided to increase the dose to two tabs nightly thinking
it was not making him fall asleep easily recently. The patient may be experiencing what
effect of the drug?
A. Addiction
B. Physiologic dependence
C. Psychological dependence
D. Tolerance
D. Tolerance
Which drug is a broad-spectrum anti-epileptic agent also used for bipolar disorder and
migraine prophylaxis?
A. Lamotrigine
B. Gabapentin
C. Valproic acid
D. Vigabatrin
A 2 year old female was brought to the ER due to loss of consciousness and decreased
respiratory rate. It was noted that she ingested 15 tablets of Midazolam. What is the
next best step to reverse the drug effect?
A. Endotracheal intubation
B. Gastric lavage
C. IV Flumazenil
D. IV Naloxone
C. IV Flumazenil
. A 52 year old male admitted at the ICU for myocardial infarction was given standard dose
of IV Diazepam for his anxiety. He was then noted to be lethargic with markedly
decreased cardiac rate. What best explains this occurrence?
A. Circulatory collapse
B. Depressed transmission at the skeletal neuromuscular junction
C. Inhibition of epileptiform electrical activity
D. Linear dose-response
A. Circulatory collapse
The mechanism of action of this drug involves binding particularly at the a1 subunit of
GABAA receptor.
A. Chlordiazepoxide
B. Clorazepate
C. Eszopiclone
D. Midazolam
D. Midazolam
. This property of Phenobarbital best explains its sedative-hypnotic action.
A. Alkalinization of the urine increases its elimination
B. Binds at the a1 and B2 subunits of GABAA receptor
C. Increases duration of chloride channel opening
D. Inhibits glutamic acid neurotransmission
C. Increases duration of chloride channel opening
Which antiseizure medication can cause visual field defects as a potential side effect?
A. V igabatrin
B. Carbamazepine
C. Ethosuximide
D. Valproic acid
A. V igabatrin
Which second-generation antiseizure medication is specifically used to treat seizures
associated with Lennox-Gastaut syndrome?
A. Zonisamide
B. Biguanides
C. Rufinamide
D. Phenytoin
C. Rufinamide
