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Pharma > FINALS: Reviewer > Flashcards

FINALS: Reviewer Flashcards

1
Q

Which of the following is the classification of doxorubicin?
A) antifolate
B) antimetabolite
C) anthracycline
D) alkylating agent

A

C) anthracycline

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2
Q

Which of the following agents stabilizes microtubule assembly?
A) dasatinib
B) docetaxel
C) doxorubicin
D) dacarbazine

A

B) docetaxel

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3
Q

What is the classification of melphalan?
A) antitolate
B) antimetabolite
C) anthracycline
D) alkylating agent

A

A) antitolate

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4
Q

Which of the following adverse effects is MOST common with cisplatin?
A) pulmonary fibrosis
C) hemorrhagic cystitis
B) nephrotoxicity
D) cardiotoxicity

A

D) cardiotoxicity

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5
Q

Which of the following acts on the and inhibits progression at N7 of guanine?
A) oxaliplatin
C) teniposide
B) procarbazine
D) vinorelbine

A

B) procarbazine

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6
Q

Which antineoplastic agent is CORRECTLY matched with the corresponding cell cycle phase it acts on?
A) cabazitaxel - M
B) docetaxel - G1
C) epirubicin - G2
D) fludarabine - S

A

A) cabazitaxel - M

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7
Q

Which agent inhibits topoisomerase II?
A) bleomycin
B) etoposide
C) irinotecan
D) letrozole

A

B) etoposide

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8
Q

Which agent targets and inhibits tyrosine kinase?
A) bevacizumab
B) dasatinib
C) doxorubicin
D) gemcitabine

A

B) dasatinib

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9
Q

Which of the following is the indication for use of oxaliplatin?
A) acute myelogenous leukemia
B) choriocarcinoma
C.) colon cancer
D) pleurodesis

A

C.) colon cancer

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9
Q

. Which of the following is classified as an androgen receptor blocker?
A) abarelix
B) exemestane
C) fluorouracil
d) flutamide

A

d) flutamide

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10
Q

In a patient with advanced stage ovarían cancer combination chemotherapy will be given after the surgical
removal of the uterus, fallopian tubes, ovaries, omentum and pelvic lymph nodes. What is the purpose or role of chemotherapy?
A) adjuvant
B) concurrent
C) palliative
D) primary induction

A

A) adjuvant

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11
Q

. Which of the following is classified as a cell cycle specific antineoplastic agent?
A) bleomycin
B) carboplatin
C) cyclophosphamide
D) doxorubicin

A

C) cyclophosphamide

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11
Q

Which specific system is the adverse effect of busulfan MOST likely to occur?
A) cardiac
B) neurologic
C) pulmonary
D) renal

A

C) pulmonary

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12
Q

Which agent can kill tumors in both the resting and cycling phases?
A) docetaxel
C) teniposide
B) epirubicin
D) vinorelbine

A

B) epirubicin

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13
Q

Which of the following is TRUE regarding the log cell kill kinetics of cancer chemotherapy agents?
A) a greater proportion of cells is killed as the tumor is larger
B) at a given dose, a constant fraction of cancer cells is killed
C) a constant number of tumor cells are killed at a particular dose
D) the smaller the tumor the less number of cells killed

A

B) at a given dose, a constant fraction of cancer cells is killed

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14
Q

Which of the following is the classification of cyclophosphamide?
A) antifolate C) anthracycline B) antimetabolite D) alkylating agent

A

D) alkylating agent

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15
Q

Which agent acts by inhibiting topoisomerase II?
A) bevacizumab
C) etoposide
B) dazatinib
D) gemcitabine

A

C) etoposide

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16
Q

Which of the following agents is associated with nephrotoxicity?
A) bleomycin C) paclitaxel B) cisplatin D) vincristine

A

B) cisplatin

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16
Q

At what phase does vincristine primarily act?
A) G1 C) M B) S D) Any phase it is cell cycle non-specific

A

C) M

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17
Q

Which of the following agents is used to promote pulmonary fibrosis?
A) 5-fluorouracil C) melphalan B) bleomycin D) oxaliplatin

A

B) bleomycin

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18
Q

Which of the following agents crosses the blood brain barrier?
A) cyclophosphamide C) carmustine B) capecitabine D) carboplatin

A

C) carmustine

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19
Q

Which drug class has increase in DNA repair as the mechanism for resistance?
A) antimetabolite C) platinum analogs B) akylating agents D) taxanes

A

B) akylating

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20
Q

Which agent is indicated for colorectal cancer?
A) oxaliplatin C) gemcitabine B) melphalan D) etoposide

A

A) oxaliplatin

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21
Q

Leucovorin is the rescue therapy for which agent?
A) cisplatin C) ifosfamide B) doxorubicin D) methotrexate

A

D) methotrexate

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22
Q

Which of the following chemotherapy agents has cell cycle specific effects?
A) bleomycin C) cisplatin B) busulfan D) epirubicin

A

A) bleomycin

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23
Q

The following drugs are inhibitors of cell wall synth
A. Carbapenems
B. Cephalosporins
C.Macrolides
D. Penicillin

A

D. Penicillin

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24
Q

Penicillin is classified as a agent
A. Bactericidal
B. Bacteriostatic.

A

A. Bactericidal

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25
Q

Which of the following adverse effects is classified as indirect toxicity?
A. Anaphylaxis
B. Bacteriostatic.
C. Ototoxicity
B. Oral candidiasis

A

B. Oral candidiasis

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26
Q

Anaerobes are innately resistant to aminoglycosides because intracellular accumulation is oxygen-dependent. This is an example of resistance.
A. Acquired
B. Innate

A

B. Innate

27
Q

The following cell wall synthesis inhibitors inhibit peptidoglycan cross-linking EXCEPT
A. Carbapenems
С.Penicillin
B. Cephalosporin
D. Vancomycin

A

D. Vancomycin

28
Q

Amoxicillin is classified as
A. B-lactamase resistant; narrow spectrum
B. B-lactamase susceptible; broad spectrum
C. B-lactamase susceptible; narrow spectrum

A

B. B-lactamase susceptible; broad spectrum

29
Q

. The MAJOR mechanism of resistance developed by most staphylococci and many gram-negative organisms against penicillin is
A. Changes in porin structure
B. Formation of beta-lactamases
C. Structural change in target penicillin-binding proteins

A

B. Formation of beta-lactamases

30
Q

Which penicillin is primarily used for the treatment of known or suspected staphylococcal infections?
A. Amoxicillin
C. Oxacillin
B. Ampicillin
D. Penicillin G

A

C. Oxacillin

31
Q
A
31
Q

The major route of elimination of cephalosporins is via
excretion.
A. Biliary
B. Renal

A

B. Renal

32
Q

Complete cross-allergenicity between different penicillins should be assumed
A. TRUE
B.FALSE

A

A. TRUE

32
Q

The following drugs are inhibitors of cell wall synthesis:
A. Carbapenems
B. Cephalosporins
C. Macrolides
D. Penicillin

A

D. Penicillin (pero sabi pati din si a & b)

33
Q

Penicillin is classified as a bactericidal agent:
A. Bactericidal
B. Bacteriostatic

A

A. Bactericidal

34
Q

Which of the following adverse effects is classified as indirect toxicity?
A. Anaphylaxis
B. Bacteriostatic
C. Ototoxicity
D. Oral candidiasis

A

D. Oral candidiasis

35
Q

Anaerobes are innately resistant to aminoglycosides because intracellular accumulation is oxygen-dependent. This is an example of innate resistance:
A. Acquired
B. Innate

A

B. Innate

36
Q

The following cell wall synthesis inhibitors inhibit peptidoglycan cross-linking EXCEPT:
A. Carbapenems
B. Cephalosporin
C. Vancomycin
D. Penicillin

A

C. Vancomycin

37
Q

Amoxicillin is classified as:
A. B-lactamase resistant; narrow spectrum
B. B-lactamase susceptible; broad spectrum
C. B-lactamase susceptible; narrow spectrum

A

B. B-lactamase susceptible; broad spectrum

37
Q

This long acting bronchodilator can be given as controller medication for bronchial asthma.
A. Albuterol B. Formoterol C. Metaproterenol D. Terbutaline

A

B. Formoterol

38
Q

The major mechanism of resistance developed by most staphylococci and many gram-negative organisms against penicillin is:
A. Changes in porin structure
B. Formation of beta-lactamases
C. Structural change in target penicillin-binding proteins

A

B. Formation of beta-lactamases

38
Q

Which penicillin is primarily used for the treatment of known or suspected staphylococcal infections?
A. Amoxicillin
B. Oxacillin
C. Ampicillin
D. Penicillin G

A

B. Oxacillin

39
Q

This corticosteroid can be given for bronchial asthma management.
A. Aminophylline C. Cromolyn B. Budesonide D. Theophylline

A

B. Budesonide

40
Q

Mechanism of action of this anti-inflammatory agent is through inhibition of cytokine gene expression and phospholipase A2.
A. Antimuscarinic agent B. Corticosteroid C. Methylxanthine D. Leukotriene receptor antagonist

A

B. Corticosteroid

41
Q

This is considered a non-selective beta agonist.
A. Epinephrine B. Phenylpropanolamine C. Salbutamol D. Salmeterol

A

A. Epinephrine

41
Q

This drug enhances bronchodilation by inhibiting the phosphodiesterase (PDE) enzyme located in bronchial smooth-muscle cells.
A. Cromolyn B. Fluticasone C. Theophylline D. Tiotropium

A

C. Theophylline

42
Q

This is a systemic corticosteroid used to treat acute asthma attack.
A. Beclomethasone B. Budesonide C. Flunisolide D. Prednisone

A

D. Prednisone

43
Q

This drug is given to address upper respiratory tract infection.
A. Carbocisteine B. Cromolyn sodium C. Methylprednisolone D. Montelukast

A

A. Carbocisteine

44
Q

he mechanism of action of this asthma drug is through inhibition of leukotriene receptors.
A. Betamethasone B. Cromolyn C. Montelukast D. Tiotropium

A

C. Montelukast

45
Q

A 22 year old female being treated for bronchial asthma attack was given an inhalational agent. The patient then developed tremors after. What agent may have caused this?
A. Albuterol B. Dexamethasone C. Nedocromil D. Zafirlukast

A

A. Albuterol

46
Q

A 67 year old male came in due to COPD exacerbation. He was given an inhalational agent which afforded relief of difficulty of breathing. However, the patient developed urinary retention and dry mouth. What agent may have caused this?
A. Albuterol B. Ipratropium C. Salmeterol D. Terbutaline

A

B. Ipratropium

47
Q

Complete cross-allergenicity between different penicillins should be assumed:
A. TRUE
B. FALSE

A

A. TRUE

48
Q

1st-generation cephalosporins are used primarily against gram-positive cocci with minimal gram-negative activity:
A. 1st
B. 2nd

A

A. 1st

48
Q

The major route of elimination of cephalosporins is via renal excretion:
A. Biliary
B. Renal

A

B. Renal

49
Q

When combined with ethanol, cefamandole can cause a disulfiram-like reaction:
A. Acetaminophen
B. Diazepam
C. Disulfiram
D. Ketamine

A

C. Disulfiram

50
Q

This beta-lactam antibiotic is a safe alternative for patients with penicillin or cephalosporin allergy but has no activity against gram-positive bacteria:
A. Aztreonam
B. Bacitracin
C. Daptomycin
D. Meropenem

A

A. Aztreonam

51
Q

Which of the following acts as suicide inhibitors of bacterial penicillinases?
A. Clavulanic acid
B. Colistin

A

A. Clavulanic acid

51
Q

This is the drug of choice for MRSA and is associated with red man syndrome:
A. Cycloserine
B. Ertapenem
C. Fosfomycin
D. Vancomycin

A

D. Vancomycin

52
Q

Inhibits phosphorylation/dephosphorylation cycling

A

Bacitracin

53
Q

Blocks incorporation of d-Ala into the pentapeptide side chain of the peptidoglycan

A

Cycloserine

54
Q

T or F
Daptomycin Causes membrane depolarization, forming transmembrane channels

A

TRUE

54
Q

T or F
Fosfomycin Inhibitor of cytosolic enolpyruvate transferase

A

TRUE

54
Q

T or F
Vancomycin Inhibitor of cytosolic enolpyruvate transferase

A

FALSE
Vancomycin - A (Binds to the d-Ala-d-Ala terminal of the nascent peptidoglycan pentapeptide side chain, inhibiting transglycosylation)

54
Q
A
55
Q
A
56
Q
A
57
Q
A

Pharma (14 decks)

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