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Hematology 2 > Midterms > Flashcards

Midterms Flashcards

1
Q

Anemia characterized by increased destruction of RBCs and decreased erythropoiesis

A

Hemolytic anemia

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2
Q

Causes of intrinsic hemolytic anemia

A

Hemoglobinopathies
Membranopathies
Enzymopathies

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3
Q

Examples of hemoglobinopathies associated with intrinsic HA

A

Sickle cell anemia

Thalassemia

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4
Q

Condition in bone marrow due to high production of RBCs

A

Erythroid hyperplasia

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5
Q

Proteins involved in hereditary spherocytosis

A

Band 3
Ankyrin
Spectrin

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6
Q

Proteins involved in hereditary elliptocytosis

A

Protein 4.1

Spectrin

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7
Q

Protein for anion transport

A

Band 3

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8
Q

Connects band 3 and ankyrin

A

Protein 4.1

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9
Q

Protein of primary cytoskeleton

A

Spectrin

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10
Q

Proteins for flexibility of cell membrane

A

Actin
Tropomyosin
Protein 4.1

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11
Q

Cause of intravascular HA

A

Synthetic heart valve

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12
Q

Enzymopathies in HA result to

A

Splenomegaly
Heinz bodies
Bite cells

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13
Q

G6PD is part of what pathway

A

HMP (hexose monophosphate pathway)

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14
Q

Products of G6P + NADP rxn

A

NADPH + phosphogluconate

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15
Q

Utilizes NADPH for removal of stress oxidant (ROS)

A

Glutathione reductase

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16
Q

Normal relationship of NADPH and ROS

A

High NADPH, low ROS

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17
Q

Abnormal relationship of NADPH and ROS

A

Low NADPH, high ROS

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18
Q

Heinz bodies are stained by

A

Supravital stain

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19
Q

High ROS = ? Hb denaturation

A

Increased

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20
Q

Enzyme for ATP production

A

Pyruvate kinase

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21
Q

Poikilocyte resulting from the sequestration of spleen

A

Bite cell

22
Q

Substance that inhibits pyrimidine-5-nucleotidase

A

Lead/Pb

23
Q

RBC inclusion related to pyrimidine-5-nucleotidase

A

Basophilic stippling

24
Q

Condition of extrinsic hemolytic anemia involved in prehepatic jaundice

A

IMHA

25
Q

Transcribe IMHA

A

Immune mediated hemolytic anemia

26
Q

Test ideal for autoimmune HA

A

Coomb’s test or direct agglutination test

27
Q

Small clots cause bursting of RBCs within a vessel (name the condition)

A

Microangiopathic hemolytic anemia (MAHA)

28
Q

Causes of MAHA

A

DIC, TTP

29
Q

Poikilocyte found in MAHA

A

Schistocyte

30
Q

Individuals with this condition is rsistant to malaria

A

Duffy null (no Duffy Ag)

31
Q

Duffy Ag is the receptor to what species

A

P. knowlesi, P. vivax

32
Q

Fetal Rh incompatibility causes what disease

A

HDN

33
Q

Treatment to sensitize the mother’s RBCs

A

RhoGAM

34
Q

Hereditary spherocytosis is most common in what race

A

Northern Europeans

35
Q

Spherocytes have _ surface/volume ratio

A

Low

36
Q

T/F: Spherocytes cannot stretch

A

T (true)

37
Q

Most impt. test/parameter for spherocytosis

A

EOFT

38
Q

RBCs in hypertonic solution

A

Shrink/crenate

39
Q

RBCs in hypotonic solution

A

Swell/burst

40
Q

Coomb’s test result for spherocytosis

A

Negative

41
Q

MCV for spherocytosis

A

Normal or decreased

42
Q

The only condition with hyperchromia (high MCHC)

A

Hereditary spherocytosis

43
Q

Brain tissues bacome yellowish

A

Kernicterous

44
Q

Concentration of bilirubin to cause kernicterous condition

A

20mg/dL

45
Q

Findings in UTZ(ultrasound) test in spherocytosis

A

Cholelithiasis (gall stones)

46
Q

Gallstones are formed from ____ + _____

A

Ca + B1

47
Q

Test useful to detect Band 3

A

Eosin-5-maleimide

48
Q

Differrential test for hereditary spherocytosis and elliptocytosis

A

Eosin-5-maleimide

49
Q

Condition in which the sinusoids of the spleen may be blocked

A

Hereditary elliptocytosis

50
Q

Heat sensitive variant of hereditary elliptocytosis

A

Hereditary pyropoikilocytosis

51
Q

MCHC in her. elliptocytosis

A

Normal

52
Q

Hereditary ovalocytosis is also known as

A

Southeast Asian Ovalocytosis

Hematology 2 (2 decks)

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