Midterm Lec Flashcards

1
Q

3 types of diabetes

A

Type 1 dm -Insulin dependent
Type 2 DM -Insulin dependent
Type 3c DM -

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2
Q

Type 3c DM

A

Major criteria - presence of exocrine pancreatic insufficiency
Pathological pancreatic imaging
Absence of T1DM-Associated autoimmune markers

Minor criteria

Impaired beta cell function
No excessive insulin resistance
Impaired incretin
Low serum levels of lipid, soluble vitamins

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3
Q

Causes of T3CDM

A

Chronic pancreatitis
Acute pancreatitis
Pancreatic cancer
Hemochromatosis
Cystic fibrosis
Pancreatectomy

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4
Q

It refers to diabetes occuring as a result of the disease of the exocrine pancreas.

It is often under diagnosed and under reported & constitutes abt. 0.5 - 1.15% of DM

A

Type 3c DM

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5
Q

Type 2 DM

A

Non insulin dependent
Adult type/maturity onset diabetes mellitus
Stable diabetes
Ketosis resistant
Receptor deficient dm

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6
Q

It is characterized by hyperglycemia due to n individuals resistance to insulin

Geneticist’s nightmare

Has milder symptoms

A

Type 2 Dm

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7
Q

The untreated type 2 dm will result to

A

non ketonic hyperosmolar coma

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8
Q

Risk factors for type 2 dm

A

Obesity, family history, advance age, hypertension, lack of excercise, GDM, Impaired glucose metabolism

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9
Q

Type 1 diabetes

A

Juvenile onset DM
Brittle diabetes
ketosis prone diabetes

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10
Q

A result of cellular mediated autoimmune destruction of the beta cell of the pancreas

A

Type 1 dm

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11
Q

Diabetic individuals have

A

Insulinopenia

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12
Q

Genetic associations between type 1 dm _______ - the major locus is rge major histocompatibility complez on chromosome no.?

A

Hla DR3 & DR4
Chromosome no. 6

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13
Q

Individuals at greater risk of developing this type of diabetes have high titers of multiple autoantibodies -__________________________

A

Glutamic & deoxycarboxylase(GAD 65) & Insulin autoantibody

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14
Q

Signs and symptoms of type 1

A

Polyuria, polydipya, polyphagia, , rapid weight loss, hyperventilation, mental confusion and possible loss of consciousness.

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15
Q

Complications of type 1 dm

A

Complications: microvascular disorders - nephropathy, neuropathy and retinopathy

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16
Q

Form of type 1 dm that has known etiology & strongly inherited

Doesn’t have beta cell antibody and have episodic requirements for insulin replacement

A

Idiopathic type 1 dm

17
Q

Disorder characterized by impaired ability to metabolize carbohydrates usually caused by deficiency of insulin metabolico or hormonal changes

Type of glucose intolerance woth oneset or first recognition during pregnancy

Screening should be performed between _ - _ weeks?

A

Gestational DM

24-28 Weeks

18
Q

Revised diagnostic criteria for gdm

A
  1. FBS=92 mg/dl
  2. 1 hr. Gct >180mg/dl
  3. 2 hr. Ogtt >153mg/dl
19
Q

Other specific type of diabetes

A
  1. Pancreatic disorders/Pancreatectomy❑
  2. Endocrine disorders - Cushing’s syndrome, pheochromocytoma, acromegaly and hyperthyroidism❑
  3. Drugs or chemical inducers of B-cell dysfunction (dilantin and pentamidine) and impair insulin action (thiazides, glucocorticoids)❑
  4. Genetic syndromes - Down syndrome, Klinefelter’s syndrome, Rabson-Mendengall syndrome, Leprechaunism, Huntington’s chorea and Turner syndrome❑
  5. Exocrine disorders - cystic fibrosis, neoplasia and hemochromatosis
20
Q

Mean

A

Often card s the average
Commonly

21
Q

Median

A

Middle Point
Skewed data

22
Q

Mode

A

Rarely used as a measure of data
More often used to describe data that seem to have 2 centers (i.e. bimodal)

23
Q

Types of error

A

Random
Systematic
Proportional
Constant
Total

24
Q

Due to instrument, operator and environmental conditions-precision

A

Random error

25
Q

Often related to calibration prob. Deterioration of reag. Control mat. Improperly made standards etc. -accuracy

A

Systematic error

26
Q

It refers to the difference between the target value and the assayed value

A

Constant error

27
Q

Results in greater deviation from target value due to higher sample concentration

A

Proportional/slope/percent error

28
Q

Highest frequency of clerical errors w/ use of hand written labels and requests form

A

Clerrical error

29
Q

Allowable error

A

Bsed on quantity that will negatively affect clinicak decisions

Total error must be less than e. Or fixed limits for a method to be considered acceptable

Determination of whether long term precision is sufficient based on the total imprecision being less than 1/3 of the allowable error