Midterm Lec Flashcards
3 types of diabetes
Type 1 dm -Insulin dependent
Type 2 DM -Insulin dependent
Type 3c DM -
Type 3c DM
Major criteria - presence of exocrine pancreatic insufficiency
Pathological pancreatic imaging
Absence of T1DM-Associated autoimmune markers
Minor criteria
Impaired beta cell function
No excessive insulin resistance
Impaired incretin
Low serum levels of lipid, soluble vitamins
Causes of T3CDM
Chronic pancreatitis
Acute pancreatitis
Pancreatic cancer
Hemochromatosis
Cystic fibrosis
Pancreatectomy
It refers to diabetes occuring as a result of the disease of the exocrine pancreas.
It is often under diagnosed and under reported & constitutes abt. 0.5 - 1.15% of DM
Type 3c DM
Type 2 DM
Non insulin dependent
Adult type/maturity onset diabetes mellitus
Stable diabetes
Ketosis resistant
Receptor deficient dm
It is characterized by hyperglycemia due to n individuals resistance to insulin
Geneticist’s nightmare
Has milder symptoms
Type 2 Dm
The untreated type 2 dm will result to
non ketonic hyperosmolar coma
Risk factors for type 2 dm
Obesity, family history, advance age, hypertension, lack of excercise, GDM, Impaired glucose metabolism
Type 1 diabetes
Juvenile onset DM
Brittle diabetes
ketosis prone diabetes
A result of cellular mediated autoimmune destruction of the beta cell of the pancreas
Type 1 dm
Diabetic individuals have
Insulinopenia
Genetic associations between type 1 dm _______ - the major locus is rge major histocompatibility complez on chromosome no.?
Hla DR3 & DR4
Chromosome no. 6
Individuals at greater risk of developing this type of diabetes have high titers of multiple autoantibodies -__________________________
Glutamic & deoxycarboxylase(GAD 65) & Insulin autoantibody
Signs and symptoms of type 1
Polyuria, polydipya, polyphagia, , rapid weight loss, hyperventilation, mental confusion and possible loss of consciousness.
Complications of type 1 dm
Complications: microvascular disorders - nephropathy, neuropathy and retinopathy