Midterm BONCO Questions Flashcards
What is the unique CCNU toxicity seen in dogs?
hepatotoxicity
What is the main risk factor linked to cutaneous squamous cell carcinoma in dogs and cats?
sunlight exposure
When should GI and bone marrow side effects be expected following chemotherapy?
GI: within 3 to 5 days
bone marrow: within 5 to 7 days
What are the two most important prognostic indicators in canine lymphoma?
-clinical substage
-phenotype
What are the three pathways of metastasis?
-direct seeding
-lymphatics
-blood vessels
How does staging differ from grading?
staging: clinical assessment of cancer spread done by oncologist/primary clinician
grading: histopath evaluation of cancer features done by pathologist
What stage of lymphoma involves peripheral lymphadenopathy and circulating neoplastic cells on CBC?
stage 5
What are the 4 requirements to get a margin evaluation on histopath.?
-ink margins
-submit whole tissue
-no cautery or laser on margin
-do not incise margin
Which information can be gathered from an incisional biopsy?
-tumor type
-tumor grade
Why is staging important?
it helps to determine an animal’s prognosis and determine the best steps for treatment
Which types of feline LSA have the best prognosis?
-small cell GI
-nasal
What is the most important risk factor for development of LSA in cats?
FeLV + status
What are the stages of neoplastic transformation?
-initiation
-promotion
-progression
What is the best treatment option for feline small cell GI LSA?
chlorambucil and prednisolone; both PO
What is the minimum number of neutrophils a patient must have in order to safely provide a chemotherapy treatment?
2500+
What stage of neoplastic transformation absolutely requires a genetic event?
initiation
What is the standard of care for canine LSA?
multi-drug therapy/CHOP
What is the most important prognostic indicator for feline LSA?
response to treatment
What are the unique doxorubicin toxicities in dogs and cats?
dogs: cardiotoxicity
cats: nephrotoxicity
What are the 4 Rs of radiation therapy?
-repair
-repopulation
-redistribution
-reoxygenation
What is the most common presentation of feline LSA?
small cell GI LSA
What is the fundamental feature that defines all neoplasia?
uncontrolled cell proliferation
How many neutrophils are needed to prevent sepsis?
1000+
