(MIDTERM) Beta-Lactam Antibiotics: Penicillin

Question 1

Accidental discovery in 1928 of a mold inhibiting the growth of bacteria on a petri dish

Answer 1

Sir Alexander Fleming

Question 2

Formerly: Penicillium chrysogenum

Answer 2

Penicillium notatum

Question 2

Through isolation of mold extracts

Answer 2

Discovery of the Beta-Lactam Ring

Question 3

Howard Florey and Ernst Chain at Oxford University in 1939

Answer 3

Isolation and Mass Production of Penicillin

Question 3

Published the first study in 1929

Answer 3

Discovery of the Beta-Lactam Ring

Question 4

Classification of Antibiotics that Posses the B-lactam Ring:

Answer 4

four-membered cyclic amide

Question 5

Classification of Antibiotics that Posses the B-lactam Ring;
Members:

Answer 5

1.) Penciliins
2.) Cephalosphorins
3.) Carbapenems
4.) Monobactams

Question 6

Process: Transpeptidase enzyme catalyzes the cross-linking of N-acetylmuramic acid
(NAM) and N-acetylglucosamine (NAG) via connection of the NAM Residues

Answer 6

Understanding the Biosynthesis of Peptidoglycan

Question 6

Understanding the Biosynthesis of Peptidoglycan;
Product:

Answer 6

Peptidoglycan

Question 7

Binding to the Penicillin Binding Proteins (PBPs) Active Site

Answer 7

MOA

Question 7

Component of the bacterial cell wall that provides strength and rigidity

Answer 7

Peptidoglycan