Midterm 4 Info (göz) Flashcards

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1
Q

What is glaucoma¿

A

Göz tansiyonu

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2
Q

What is optic neuritis¿

A

Inflammation of the optic nerve. Mostly viral

Usually young adults (5 females:1
male)

Visual acuity is usually affected with
central scotoma as the classic finding

Relative afferent pupillary defect may
persist even after the visual function
improves

Visual-evoked potential: prolonged
P100

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3
Q

What is papilledema¿

A

Papilödem, beyin içinde veya çevresinde artan basıncın göz içindeki optik sinirin bir kısmının şişmesine neden olan bir göz rahatsızlığıdır. Artan kafa içi basınç optik sinirin gözün arkasına girerken şişmesine neden olur.

Associated with bilateral optic disc edema due to elevated intracranial pressure
Compression of the venous structures within the nerve head that causes venous engorgement and tortuosity, capillary dilation, and splinter hemorrhage

Etiologies
i. Intracranial mass lesion
ii. Pseudotumor cerebri
iii. Hydrocephalus
iv. Intracranial hemorrhage
v. Venous thrombosis/obstruction
vi. Meningitis

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4
Q

What is Horner’s syndrome¿

A

Sempatik sinir sistem hasarının gözdeki hali.

Symptoms i. Miosis ii. Ptosis (denervation of Müller’s muscle) iii. Anhidrosis (ipsilateral facial)

May result from any one of a variety of factors:
• Carotid artery dissection
• The development of a tumor in neck or chest cavity, particularly a
neuroblastoma and a tumor of the upper part of the lung (Pancoast
tumor)
• The development of a lesion in midbrain, brain stem, upper spinal
cord, neck, or eye orbit

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5
Q

What are miosis midriasis and ptosis¿

A

Miosis—> Göz bebeğinin küçülmesi. Tersi midriasis.
Ptosis—> Göz kapağının düşmesi. Göz tembelliğine yol açar

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6
Q

AMAUROTIC LIGHT REFLEX nedir¿

A

Lesions of the optic nerve or retina on the affected side complete blindness

Absence of direct light reflex on the affected side AND absence of indirect light reflex on the normal side

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7
Q

relative afferent pupillary defect (RAPD) nedir

A

RÖLATİF AFERAN PUPİL DEFEKTİ (RAPD) (Marcus Gunn Pupil bir çeşididir): İnkomplet optik sinir lezyonu (glokom, optik nevrit, anterior iskemik optik nöropati vb.) veya şiddetli retinal hastalıklarda görülen bir durumdur. Fakat katarakt gibi durumlarda görülmez. Bu tablo en iyi “sallanan fener testi” ile tespit edilebilir

The swinging flashlight test is used to elicit a relative afferent pupillary defect (RAPD)
If you shine a light into one eye of a normal subject, both pupils constrict to the same degree. If you swing
the light over to the other eye, the pupil stays the same size or constricts minimally
In patients with RAPD the affected eye behaves as if it perceives a dimmer light than the normal eye;
therefore, both pupils constrict to a lesser degree when the light is shone in the affected eye
If you shine the light in the right eye of a patient with left RAPD, both pupils constrict. If you swing the light
to the left eye, it is perceived as dimmer and the pupils dilate

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8
Q

What is MARCUS GUNN PUPIL

A

It is a type of relative afferent pupil defect (RAPD)

Presence of a relative afferent pathway defect (RAPD) due to
incomplete optic nerve lesions or
severe retinal disease

Paradoxical response of a pupil to
light

Marcus Gunn pupil refers to the unequal pupillary response to light due to damage or disease in the retina or optic nerve.

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9
Q

ARGYLL ROBERTSON PUPIL what is it

A

Reaction to near reflex is present, but light reflex is absent
Lesions in the region of tectum
Both pupils are slightly small in size

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10
Q

ARGYLL ROBERTSON PUPIL (Light–Near Dissociation) reasons¿

A

Unilateral
• Afferent conduction defect
• Adie pupil
• Herpes zoster ophthalmicus
Aberrant regeneration of the third cranial nerve

Bilateral
• Neurosyphilis
• Type 1 diabetes mellitus
Myotonic dystrophy
Parinaud (dorsal midbrain) syndrome
Familial amyloidosis
Encephalitis
Chronic alcoholism

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11
Q

What is efferent pathway reflex

A

Absence of both direct & indirect light reflex and also near reflex on the affected side
Presence of all reflexes on normal side
Efferent pathway defect (sphincter paralysis)
Parasympatholytic drug (eg: atropine)
Internal opthalmoplegia
Third nerve paralysis

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12
Q

What is adie pupil¿

A

It typically affects young women and presents in one eye in
80%, though involvement of the second eye typically develops
within months or years. • Sites of dysfunction are presumed to be the ciliary ganglion • The affected pupil is larger (anisocoria). • Symptoms. Patients may notice anisocoria, or may have
blurring for near due to impaired accommodation.
• The direct light reflex is absent or sluggish • Constriction is also absent or sluggish in response to light
stimulation of the fellow eye (consensual light reflex • The pupil responds slowly to near, following which redilatation
is also slow. • Instillation of 0.1–0.125% pilocarpine into both eyes leads to
constriction of the abnormal pupil due to denervation
hypersensitivity, with the normal pupil unaffected.

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13
Q

ANISOCORIA nedir

A

Difference between the size of two pupils

The asymmetry persists to the same proportion under differing
levels of illumination

Physiological anisocoria: usually minimal, both pupils react well to light, no dilatation lag
Pathological anisocoria: Usually a difference of 2mm or more, may be either due to abnormal miosis or mydriasis of one pupil
Exceptionally, apraclonidine or cocaine testing may be needed to exclude Horner syndrome.

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14
Q

Info card

A

Acquired causes of pupil irregularity • Blunt trauma - focal tear in sphincter muscle • Iridodialysis - outer edge of iris is torn from ciliary attachment • Synechiae - inflammation can damage iris leading adherence to lens or cornea • Neovascularization- distort iris and impair reactivity • Surgical procedure in anterior segment, cataract

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15
Q

Optic nerve lesion results

A

Visual field deficits (anopsia)
Loss of light reflex with III
Only nerve to be affected by MS

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16
Q

Oculamotor nerve lesions

A

Diplopia, external strabismus • Loss of parallel gaze • Ptosis • Dilated pupil, loss of light reflex with II • Loss of near response

Function of oculamotor nerve

Innervates Superior rectus, medial rectus, inferior rectus, inferior oblique and
levator palpebra superioris • Raises eyelid (levator palpebrae superioris) • Constricts pupil (sphincter pupillae) • Accommodates (ciliary muscle)

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17
Q

Trochlear nerve lesion results

A

RESULTS OF LESIONS • The involved eye is elevated during primary
(forward) gaze • The extent of elevation increases during
adduction and decreases during abduction
Vertical and torsional diplopia • Diplopia is most pronounced when the
patient looks downward with the affected
eye adducted

18
Q

Abducens nerve lesions

A

An abducens nerve lesion
causes paralysis of the lateral
rectus muscle, resulting in
adduction of the involved eye
at rest and failure of attempted
abduction •

Diplopia occurs on lateral gaze
to the side of the affected eye

19
Q

What is nystagmus

A

Nystagmus is rhythmic oscillation of the
eyes • Pendular nystagmus, which usually has
its onset in infancy, occurs with equal
velocity in both directions • Jerk nystagmus is characterized by a
slow phase of movement followed by a
fast phase in the opposite direction

20
Q

What are the 4 age related acquired cataract types¿

A

nuclear, cortical, subcapsular and polychromatic (‘Christmas tree’) cataracts

21
Q

What are the 3 acquired cataracts caused by systemic disorders

A

Diabetes mellitus
• Hyperglycaemia is reflected in a high level of glucose in the aqueous humour, which
diffuses into the lens. Here glucose is metabolized into sorbitol, which accumulates within
the lens, resulting in secondary osmotic overhydration.

Atopic dermatitis
• About 10% of patients with severe atopic dermatitis develop cataracts in the second to
fourth decades. These are often bilateral and may mature quickly Neurofibromatosis type 2 •

Neurofibromatosis type 2
is associated with early cataract in more than 60% of patients

22
Q

What is secondary acquired cataract¿

A

secondary (complicated) cataract develops as a result of other primary ocular disease

23
Q

What are some examples of secondary acquired cataracts

A

Chronic anterior uveitis is the most common cause of secondary cataract, the incidence being related to
the duration and intensity of inflammation. Topical and systemic steroids used in treatment are also
causative • Acute congestive angle closure may cause small anterior grey white subcapsular or capsular opacities • High (pathological) myopia: posterior subcapsular opacities and early onset nuclear sclerosis • Hereditary fundus dystrophies such as retinitis pigmentosa, Leber congenital amaurosis, gyrate atrophy
and Stickler syndrome are usually associated with posterior subcapsular lens opacity • Systemic and topical steroids can lead to cataract formation

24
Q

What is blunt trauma cataract have characteristic of¿

A

flower-shaped opacity

25
Q

What is the management of cataract¿

A

The only treatment option is surgery

Cataract surgery involves the replacement of the diseased lens with an intraocular lens (IOL), it is generally performed under local anaesthesia

• Phacoemulsification (gold standard): This technique uses an
ultrasonically driven needle (phaco tip) to chop the nucleus and then
aspirate the lens material.

26
Q

Secondary causes of congenital cataracts

A

Galactosaemia, Lowe syndrome, Fabry disease, Mannosidosis,Down syndrome (trisomy 21), TORCH intrauterine infections

27
Q

What is POSTERIOR CAPSULAR OPACIFICATION

A

The most common complication of late cataract surgery.

28
Q

What is coloboma of the lens¿

A

Agenesis of the lens’ some parts

29
Q

What is ECTOPIA LENTIS

A

Lens kayması.

Ek bilgi: Marfan syndrome is the most common inherited cause of ectopia lentis. Homocystinuria is the second most common inherited cause of ectopia lentis.

30
Q

What is keratitis¿

A

Keratitis, also known as a corneal ulcer, is an inflammation or irritation of the cornea.

Ek bilgi:
Bacterial keratitis: Most common pathogens are pseudomonas
aeruginosa, S. aureus, and streptococci
• Risk factors: contact lens wear, trauma, and
ocular surface disease (herpetic keratitis, bullous
keratopathy, dry eye, chronic blepharitis, corneal
anaesthesia etc.)
• Presentation: subacute onset of pain,
photophobia, blurred vision, and mucopurulent
or purulent discharge
• Signs: Epithelial defect with larger infiltrate ,
stromal oedema, anterior uveitis, often with
hypopyon and severe ulceration may lead to
descemetocele formation and perforation
Treatment—> topical antibiotics

Fungal: treatment is keratoplasty

Acanthosis k

Hsv k: Most common keratitis typw

31
Q

What is exposure keratopathy¿

A

Pathogenesis: inadequate lid closure
(lagophthalmos), resulting in inadequate corneal
wetting • Causes include facial nerve palsy, reduced muscle
tone as in coma or parkinsonism, mechanical (e.g.
eyelid scarring), and severe proptosis • Symptoms are those of dry eye.

32
Q

What are the 2 corneal degenerations¿

A

Arcus senilis: 60 + için normal. İriste lipoprotein bir halka oluşmasıdır. Gençlerde dyslipidemia ile bağlantılı.

Band keratopathy: Band-like deposition of calcium salts in Bowman layer, epithelial basement membrane,
and anterior stroma

33
Q

What is the definition of corneal dystrophy

A

Definition: A group of genetic, often progressive, eye disorders in which abnormal material often accumulates in the cornea

Corneal dystrophies may be asymptomatic in some individuals; in others they may cause significant vision
impairment

34
Q

What is wilson disease

A

Deficiency of caeruloplasmin leading to
widespread tissue deposition of copper • Presentation: liver disease, basal ganglia
dysfunction, or psychiatric disturbance,
keratopathy
• Keratopathy: zone of copper granules in
peripheral Descemet membrane
(Kayser–Fleischer ring)
• Other ocular feature: anterior capsular
‘sunflower’ cataract is less common

Anahtar nokta: sunflower cataract + Kayser–Fleischer ring

35
Q

What is keratoconus and keratoglobus¿

A

Keratoconus—> quiet shape changing of cornea.
Systemic associations: Down, Turner, Ehlers–Danlos, and Marfan syndromes, atopy and osteogenesis imperfecta.
Ocular associations: vernal keratoconjunctivitis, aniridia, retinitis pigmentosa, and persistent eye
rubbing
Presentation: during adolescence with unilateral progressive myopia and irregular astigmatism
Signs:
• Central or paracentral stromal thinning, accompanied by apical protrusion
• Red reflex shows a fairly well-delineated ‘oil droplet’
• Retinoscopy shows an irregular ‘scissoring’ reflex
• Fine vertical deep stromal stress lines (Vogt striae)
• Epithelial iron deposits may surround the base of the cone (Fleischer ring), and bulging of the lower lid in
downgaze (Munson sign)
• Acute hydrops

Keratoglobus —> total thinning of cornea. X linked, rare.

36
Q

Papilledema ve optic atrophy özellikleri

A

Papilledema: elevated optic papilla, due to increased intracranial pressure
«The border of papilla is blurred»

Optic atrophy means degeneration of the optic axons
«The papilla looks pale as a hay»

37
Q

What is Ophthalmoplegia and Internuclear ophthalmoplegia

A

Ophthalmoplegia
• paralysis or weakness of the eye
muscles or • Lesions of LMN of CN III-IV-VI

Internuclear ophthalmoplegia
• is caused by damage in
brainstem.

38
Q

What are 4 types of eye movements and their related brain areas?
(Saccadic, pursuit, Vestibular-positional/ vestibuloocular reflex, convergence)

A

4 types of eye movements
* Saccadic: the rapid movement from one point of fixation to another
(FRONTAL CONTROL)
* Pursuit: the slow eye movement used to maintain fixation on a moving object
(OCCIPITAL CONTROL)
* Vestibular-positional (vestibuloocular reflex): the eye movements that
compensate for movement of the head to maintain fixation
(CEREBELLAR AND VESTIBULAR NUCLEI CONTROL)
* Convergence: The movements that maintain fixation as an object brought close to
the face
(MIDBRAIN CONTROL)

39
Q

what is bell’s phenomenon

A

Bell’s phenomenon
* Normal turning up and out of the eye when a person closes his eyes.
In a patient with 7.nerve palsy as the eye on the paralysed side can’t
close and the movement of the globe is visible. This is normal. The
pathway for the reflex is at the brain stem level.

40
Q

VERTICAL NYSTAGMUS, what is it

A

is always CNS related