midterm 32 Flashcards
AlI DNA viruses replicate in the nucleus of the cell except:
A. Influenza virus
B. Herpesvirus 8
С.Variola virus
D. Herpes simplex type 1
E. B19
Variola virus
55-year-old male develops a rash along the T6 dermatome
on the right side of his body. His has a history of
immunosuppressive drug therapy for a transplantation
surgery. Which virus is the most likely etiologic
agent of this man’s condition?
A. Measles virus
B. Herpes simplex virus
C. Molluscum contagiosum virus
D. Rubella virus
E. Varicella-zoster virus
Varicella-zoster virus
Which one of the following is the best explanation for the selective action of acyclovir (acycloguanosine) in herpes simplex virus (HS)-infected cells?
A. Acyclovir specifically blocks the matrix protein of HS, thereby preventing release of progeny HSV.
B. None of above
C. Acyclovir is phosphorylated by a virus-encoded phosphokinase only within HSV-infected cells
D. Acyclovir binds specifically to viral receptors only on the surface of the HS-infected cell.
E. Acyclovir selectively inhibits the RNA polymerase in the HSV virion.
Acyclovir is phosphorylated by a virus-encoded phosphokinase only within HSV-infected cells
Which one of the following best describes the replication of human parvovirus B19?
A. Uses blood group antigen P as cellular receptor
B. Stimulates resting cells to proliferate
C.Production of infectious progeny requires the presence of a
helper virus
D. Readily establishes persistent infections
E. Entire replication cycle occurs in cytoplasm
Uses blood group antigen P as cellular receptor
Rotavirus represents:
A. Cancer promoting virus
B. Most common cause of common cold in adults
C. most common cause of gastroenteritis in children
D. most common cause of diarrhea in children
E. Most common cause of pneumonia
most common cause of gastroenteritis in children
which of the following are the cancer promoting virus?
A. Norwalk virus
B.HSV type 1
C. Epstein-barr virus
D. B19
E. Poliovirus
Epstein-barr virus
Cytomegalovirus is the most common cause of :
Epidemic conjunctivitis
Gastroenteritis in children is US
Congenital anomalies in US
Burkitt’s lymphoma
Pharyngitis in adults
Congenital anomalies in US
The 27 - year - old pregnant mother of a child diagnosed with erythema infectiosum is concerned for the health of her fetus . What would be the most likely outcome of fetal infection with the virus causing her child’s disease ?
Hydrocephalus
Patent ductus arteriosus
Mental retardation
Microcephaly
Hydrops fetalis
Hydrops fetalis
The use of live oral polio vaccine has been replaced by inactivated polio vaccine in many countries. Which of the following is the primary reason?
A. Only a single dose of inactivated vaccine is necessary compared
with multiple doses of the oral vaccine.
B. It is more cost effective to use the inactivated vaccine
C. Non of the above
D. There is a greater risk of vaccine-induced disease than wild virus-induced disease in areas where poliovirus has been eradicated
E.Circulating poliovirus strains have changed and the live vaccine is no longer effective in many countries
There is a greater risk of vaccine-induced disease than wild virus-induced disease in areas where poliovirus has been eradicated
Which one of the following characteristics have in common Rotavirus and Norwalk virus
A. Fecal-oral mode of transmission
B. They mainly cause disease in infants and young children
C. A double-stranded RNA genome
D. They induce generally mild disease in young children
E. Infection patterns show no seasonal variation
A. Fecal-oral mode of transmission
which one of the following doesn’t represent the disadvantage of killed-vaccine?
All of above are correct
Develops weak immunity
None of above is correct
Needs more than one dose of the shot (booster)
Poses the risk for reversion of the virulence
Poses the risk for reversion of the virulence
Which of the following viral family member has a segmented, double-stranded RNA genome and a double-
shelled capsid causing gastroenteritis?
Caliciviridae
Astroviridae
Reoviridae
Coronaveridiae
Adenoviridoe
Reoviridae
Which of the following statements regarding virus morphology is true?
AIl RNA viruses are spherical in shape
Some viruses with DNA genomes contain a primitive nucleus
Helical nucleocapsids are found with single-stranded DNA viruses
Some viruses contain flagella.
Viral surface proteins protect the viral genome from nucleases
Viral surface proteins protect the viral genome from nucleases
Which of the following statements regarding virus morphology is true?
AIl RNA viruses are spherical in shape
Some viruses with DNA genomes contain a primitive nucleus
Helical nucleocapsids are found with single-stranded DNA viruses
Some viruses contain flagella.
Viral surface proteins protect the viral genome from nucleases
Viral surface proteins protect the viral genome from nucleases
which of the following can be used as bioterrorist weapon?
Varicella-zoster
Variola
Epstein-barr virus
coxsackievirus
B19
Variola
