Midterm 2(ecto endo parasites) Flashcards
Which agent has the longest duration of action n administered in therapeutic dosages?
- Afoxolaner
- Fluralaner
- Sarolaner
- Their duration is similar
Sarolaner
What is the mechanism of action of fipronil?
- Acetylcoline receptor agonism
- Acetylcholinesterase inhibition
- GABA receptor agonism
- GABA receptor antagonism
Gaba receptor antagonism
Fluralaner is effective against…
Flea
Both of them
Demodex spp
None of them
Both of them
Which is eliminated with the urine as well?
- Fluralaner
- Afoxalaner
- Sarolaner
- Lotilaner
afoxalaner
What is the mechanism of action of indoxacarb?
- Na channel blocking
- Glutamate mediated Cl channel opening
- GABA receptor antagonsim
- Acetylcholinesterase inhibtion
Na channel Blocking
Ectoparasiticide agents can be given
- Both of them
- Orally
- Topically
- None of them
Both
Which substance is an organophosphate from the followings:
- None of them
- Propoxur
- Dinotefuran
- Both of them
none
How can coumaphos be neutralized if it gets on the skin?
- With baking soda
- With tap water
- With acetic acid
- With all of them
with baking soda
Praziquantel can NOT be used againstthe following helminth:
- Echinococcus granulosus
- Heartworm
- Both of them
- None of them
Heartworm
Which agent is the safest for the environment from the followings:
- Indoxacarb
- Imidacloprid
- Fipronil
- Permethrin
indoxacarb
How can fipronil be used in companion animals?
- Spot on
- Pour on
- Both
- None
both
Imidacloprid can be given:
- Collar
- Ijnection
- None
- Both
collar
Izoxasolines are authorized for
- Horse
- Cat
- Noth
- None
cat
What is characteristic to the mechanism of action of permethrin?
- GABA receptor agonism
- Na channel opening
- Acetlcholine receptor antagonism
- Acetylcholinesterase inhibition
Na channel opening
Which can be the side effect of Amitraz?
- Hypoglycaemia
- Both
- None
- Paralytic ileus
paralytic ileus
How can Amitraz be given?
- Collar
- Washing solution
- Both
- None
Both
Permethrin is effective agianst this parasite:
- Demodex
- Tick
- None
- Both
none
Which agent has activity against fleas?
- Fipronil
- Piriprol
- None
- Both
piropril
Which agent has activity against fleas?
- Nitenpyram
- Afoxolaner
- None
- Both
afoxolaner
Wich side effect is characteristic to organophosphates?
- Both
- None
- Difficult breathing bradycardia
- Flaccid paralysys, ataxia
none
difficulty breathing bradycardia
Propoxur poisoning causes these symptoms:
- Midriasis
- Tremor, spams
- Both
- None
midriasis
What is characteristic to the mechanism of action of permethrin?
- Gaba receptor agonims
- Na channel opening
- Acetylcholine receptor antagonism
- Acetylcholinesterase inhibition
na channel opening
What is the mechanism of action of neonicotinoids?
- Acetylcholine receptor agonism
- Acetylcholinesterase inhibtion
- Gaba receptor antagonism
- Na channel blocking
acetylcholine receptor agonism
What is the characteristic to the spectrum of febantel?
- Antitrematodal effect
- Antinematodal effect
- None
- Both
antinematodal effect
What is the characteristic to the spectrum of oxibendazole?
- Anticestodal effect
- Antinematoda effect
- Both
- None
antinematoda effect
How can albendazole be given?
- Via injection
- Both
- Orally
- None
orally
What is the characteristic to the mechanism of action of benzimidazoles?
- Tegumentum damage
- Decreased ATP production
- None
- Both
both
Which can be the side effect of Amitraz?
- Tachypnoe
- Bradycardia
- None
- Both
bradycardia
Amitraz is effective against this parasite:
- Tick
- Demodex
- Both
- None
both
Which agent is a prodrug from the followings
- None
- Triclabedazole
- Fenbendazole
- Both
none
What is the characteristic to the spectrum of oxfendazole
- Anticestodal effect
- Antinematodal effect
- None
- Both
both
Levamisole can be used against the following helminth
- Ascaris suum
- Fasciola hepática
- Dipylidium caninum
- All of them
ascaris suum
What is the characteristic to the spectrum of fenbendazole
- Hookworms
- Tapeworms
- Both
- None
both
Praziquantel can NOT be used against the following helminth
- Dipylidium caninum
- Fasciola hepática
- None
- Both
none
Repellent effect is important against
- Mosquito
- Tick
- Both
- None
both
What is the characteristic to the pharmacokinetics of praziquantel?
- Not absorbed from the skin
- Hydroxy metabolites form quickly
- Moderate distribution due to high protein binding
- None
hydroxy metabolites form quickly
Which of the following agent belongs to the imidazotiazoles
- Levamisole
- Praziquantel
- Pyrantel
- Fenbendazole
levamisole
Which of the following agent is an endectocid?
- Permethrin
- Toltrazuril
- Levamisole
- None
levamisole
Which substance is an organophosphate from the followings:
- phoxim
- Piriprol
- none
- Both of them
phoxim
What is the antidote for levamisole toxicosis
- Epinephrine
- Atropin
- N-acetylcystein
- There’s no antidote
atropin
Which agent has activity against fleas?
- Ivermectin
- Both
- None
- Indoxacarb
Both
Which can be the side effect of Amitraz?
- Sedation
- Emesis
- Both
- None
sedation
Praziquantel can be used against the helminth
- Strongylus species
- Dipylidium caninum
- None
- Both
Dipylidium caninum
What mechanism of action of organophosphates
- Irreversible inhibition of acetylcolinesterase
- Reversible inhibtion of acetylcholinesterase
- Acetylcholine receptor agonims
- Acetylcholine receptor antagonism
irreversible inhibition of acetylcolinesterase
How can levamisole be given?
- IV
- SC
- Both
- None
sc
Izoxasolines can cause these side effects in case of overdose:
- Ataxia, muscle weakness, flaccid paralysis
- Ataxia, tremor, spasm
- Sedation, hypotermia
- Emesis, bronchoconstriction, bradycardia
ataxia tremor spasm
Which is an IGR
- Both of them
- None
- Novaluron
- Methoprene
methoprene
Which is a chitin inhibitor
- Lufenuron
- Methoprene
- None
- Both
Lufenuron
Which can be an antidote of pyrethroid poisoning
- Pralidoxime
- Atipemazol
- None
- Atropin
Atropin
Which agent can be used to treat flea infection in dogs:
- Pyrantel
- Imidacloprid
- Both
- None
imidacloprid
What is the characteristic to the absorption of benzimidazoles from the GI tract?
- Their absorption is excellent, bioavailability is nearly 100%
- Their absorption is por
- Absorption is moderate
- They’re not used orally
absorption is moderate
What is the characteristic to the mechanism of action of benzimidazoles?
- None
- Agonism od the nicotinic acetylcholine receptor
- Reversible inhibition of the acetylcholinesterase
- Both
none
Which agent is effective against dermanyssus gallinae
- Pyriproxyfen
- Fluralaner
- Flumehrin
- Allof them
fluralaner
Which agent kills fleas most quickly?
- Fipronil
- Imidacloprid
- Methoprene
- Amitraz
imidacloprid
Which is true for organophosphates
- LD50 ORAL > LD50 DERMAL
- LD50 ORAL < LD50 DERMAL
- LD50 ORAL
- LD50 DERMAL
-
All of them can be correct, it depends on the substance
Deltamethrin is effective against
- Demodex spp
- Fly
- Both
- None
both
Which species is sensitive to fipronil
- Cat
- Dog
- None
- Both
none
Sarolaner is effective against
- Scabies mite
- Tick
- Both
- None
both
Dinotefuran is effective against the following parasite
- None
- Scabies mite
- Tick
- Both
tick
What is the mechanism of action of neonicotinoids
- Acetylcholine receptor agonism
- Acetylcholinesterase inhibitin
- Gaba receptor antagonism
- Na channel blocking
acetylcholine receptor agonism
Which agent is a prodrug
- Both
- None
- Febantel
- Netobimin
both
Which agent is a prodrug
- None
- Both
- Oxfendazole
- Albendazole
none
What is the characteristic to the mechanism of action of benzimidazoles?
- Damage of the endoplasmatic reticulum and mitochondrium
- Cholinergic effect
- Both
- None
Damage of the endoplasmic reticulum and mitochondrium
Benzimidazoles have the shortest duration of action in this species
- Horse
- Cattle
- Swine
- Sheep
Sheep
Resistance to benzimidazoles occurs in
- Canine taenia
- Both
- Equine strongylus
- None
equine strongylus
Which agent has activity against fleas
- Nitenpyram
- Afoxolaner
- None
- Both
both
Which species is sensitive to amitraz
- Sheep
- Cat
- Both
- None
cat
What are the symptoms of permethrin poisoning
- Hyperthermia
- Tremor
- Both
- None
tremor
How are organophosphates eliminated
- Mostly with bile
- Mostly urine
- Mostly sweat
- Mostly with saliva and exhalation
mostly urine
Which drug can be used for the treatment of pyrethroid poisoning
- Atipemazol
- Diazepam
- Both
- None
none
What is the characteristic to the mechanism of action of amitraz
- Monoamine oxidase inhibition
- Alpha 2 receptor agonist
- Both
- None
both
Which is a systemic ectoparasiticide agent
- Albendazole
- Afoxolaner
- Both
- None
both
Fluralaner is effective against
- Mosquito
- Tick
- Both
- None
tick
What is the mechanism of action of propoxur
- Reversible inhibition of acetylcholinesterase
- irreversible inhibition of acetylcholinesterase
- acetylcholine receptor agonist
- acetylchline receptor antagonist
reversible inhibition of acetylcholinesterase
how does humidity affect the toxicity of diazinon
- increases
- decreases
- doesn’t affect
- depending on the level of humifity, can increase or decrease.
increases
What is the characteristic to the mechanism of action of macrocyclic lactones
- cholinergic effect
- calcium channel damage and cosequental spastic paralysis
- teguentum damage
- opening the glutamate-mediated chloride ion channels
opening the glutamate mediated chloride ion channels
cross-resistance is possible between levamisole and
- tetrahydropyrimidines
- benzimidazoles
- pyrethroids
- isoquinoline derivates.
tetrahydropyrimidines
Which agent can cause hyperpolarization in the parasite
- moxidectin.
- Imidacloprid
- Both of them
- None
none
Which is a juvenile hormone analogue from the follwoings
- Pyriproxyfen
- Piriprol
- Pyrantel
- Permethrin
pyriproxyfen
Macrocyclic lactone can have the following side effects
- Muscle weakness, blindness, coma
- Spastic paralysis, followedby coma
- Emesis, diarrhea, fetal damage
- Salivation, bronchoconstriction, bradycardia, urination
muscle weakness, blindness coma
Which of the following agent belongs to the imidazotiazoles
- Levamisole
- Praziquantel
- Pyrantel
- Fenbendazole
levamisole
How can amitraz be given
- Chewing tablet
- Injection
- Both
- None
none
What is the characteristic to the mechanism of action of amitraz
- Alpha 2 receptor antagonism
- Inhibition of octopamine reuptake from synaptic gap
- None
- Both
inhibition of octopamine reuptake from synaptic gap
Which is the most effective agent
- Afoxolaner
- Sarolaner
- Fluralaner
- Similar efficacy
fluralaner
Praziquantel can be used against
- Ascaris suum
- Anoplocephala perfoliate
- Both
- None
Praziquantel can be used against
- Echinococcus granulosus
- Syngamus trachea (red tracheal worm)
- Both
- None
Echinococcus granulosus
What is the spectrum of fenbendazole
- Anticestodal effect
- Antinematodal effect
- Both
- None
both
Which dog breed is sensitive to levamisole
- Kuvasz
- Chihuaha
- Dobermann
- West highland white terrier
Kuvasz
How can macrocyclic lactones be given
- Topically
- Via inhalation
- Both
- None
topically
This mechanism leads to the selective toxicity of ectoparasiticide
- Slower metabolism in the parasite
- Good distribution special barriers
- Both
- None
Both
Juvenile hormone analogues are effective against this arthropod
- Scabies mite
- Fly
- Both
- None
scabies mites
Repellent effect is important against this arthropod
- Demodex
- Fly
- Both
- None
demodex
Mechanism of action of permethrin
- Gaba receptor agonis
- Na channel opening
- Acetylcholine receptor antagonism
- Acetylcholinesterase inhibition
Na channel opening
Izoxasolines can be combined with
- Pyrethroids
- Macrocyclic lactones
- Juvenile hormone analogues
- All of them
macrocyclic lactones
Propoxur poisoning causes
- Emesis, diarrhea
- Both
- Difficult breathing
- None
emesis diarrhea
Organophosphates are effective against
- Flea
- Both
- Lice
- None
Both
How can benzimidazoles be given
- Via injection
- Orally
- All of them
- Topically
all of them
What is characteristic to the pharmacokinetics of levamisole
- Quick absorption, distribution and elimination
- Poor absorption and distribution, barely crossing the special barriers
poor absorption and distribution, barely crossing the special barriers
Which is an antidote of formamidine poisoning
- Pralidoxime
- Both
- None
- Epinephrine
none
Izoxasolines can be given
- None
- Collar
- Injection
- Both
none
Nitenpyram is available in this form for companion animals
- Tablet
- Injection
Tablet
Which is an etiotropic agent
- Milbemycin oxime
- Meloxicam
- Medetomidine
- Acepromazine
Milbemycin oxime
Which of the following is an endectocid
- Flumethrin
- Triclabendazole
- Emodepszid
Flumethrin
Which species is sensitive to levamisole
- Horse
- Turkey
- Chameleon
- Sheep
horse
What is the characteristic to the mechanism of action of isoquinolones
- Reversible inhibition of the acetylcholinesterase
- Calcium metabolism famage and consequential spastic paralysis
- Inhibtion of microtubules polymerization
- Gaba receptor agonism
calcium metabolism damage and consequentia spastic paralysis
Levamisole toxicosis can cause
- Sympatic signs
- Parasympatic signs
- Svere kidney damage
- Flaccid paralysis
Parasympatic signs
Which dog breed is sensitive to ivermectin
- Only sheperds
- Only terriers
- Dogs are not sensitive
- Any breed with MDR-1 mutation
any breed with MDR 1 mutation
Izoxasolines can be given
- tablet
- none
- spot on
- Both
tablet
Which is true for amitraz
- In case of poisoning, alpha 2 receptor related symptoms occur
- Both
- Increased catecholamine effect elevates…
- None
both
Organophosphates are effective against
- Tick
- Scabies mites
- Both
- None
both
Fipronil is effective against
- Demodex canis
- None
- Both
- Ctenocephalides felis
ctenocephalides felis
Which agent has repellent effect
- Fluralaner
- Both
- Flumethrin
- None
flumethrin
Diazinon is metabolised to… in the body
- Diazoxon
- Coumaphos
- Both
- None
diazoxon
Which is an effective antidote of coumaphos poisoning
- Pralidoxime
- Epinephrine
- Digoxin
- Meloxicam
pralidoxme
What is characteristic to the pharmacokinetics of praziquantel
- Elimination only in unchanged form
- Quick and good absorption if given orally
- Cumulation in fatty tissues due to lipofilic structure
quick and good absorption if given orally
Which agent has repellent effect
- Metopren
- Both
- None
- Deltamethrin
none
Which species is the most sensitive to organophosphates
Sheep
Cat
Dog
Cattle
Which substance is an organophosphate from the followings:
- None of them
- coumaphos
- Dympilate
- Both of them
both of them
Which is not an etiotropic agent
- Doramectin
- Dinotefuran
- Dexamethasone
- Diazinon
dexamethasone
How can finopril be used in companion animals
- Tablet
- Injection
- None
- Finopril can not be used in comapanion animals
fipronil can not used in companion animals
MDR-1 gene mutation is more frequent in this dog breed
- German sheperd
- Bobtail
- The mutation doesn’t occur in these breeds
- Its similar in both of them
german shepard
Which agent does not have adulticide effect
- None
- Methoprene
- Lufenuron
- Both
both
Izoxasolines are authorized for
- Horse
- Cats
- Both
- None
cats
Which macrocyclic lactone is effective against demodicosis
- Selamectin
- Amitrazsel
- Both
- None
selamectin
What is characteristic to the pharmacokinetics of macrocyclic lactones
- They are hydrophilic substances, so they are eliminated quickly with the urine
- Their absorption is only good if they are given in injections
- They cannot cross the blood brain barrier
- They can cumulate in fatty tissues
they can accumulate in fatty tissues
Macrocyclic lactone toxicosis has higher risk in
- Some dog breeds
- Some cattle breeds
- None
- Both
some dog breeds
What is characteristic to the mechanism of action of benzimidazoles
- Inhibition of microtubules polymerization
- Inhibtion of the gaba mediated chloride ion channels
- Both
- None
inhibition of microtubles polymerization
What are the symptoms of permethrin poisoning
- Myosis
- Both
- Spams
- None
none
What is characteristic to the mechanism of action of flumethrin
- Glutamate mediated cl channel opening
- Hot foot effect
- Both
- None
hot foot effect
Repellent effect is important against
- Roundworms
- Scabies mites
- None
- Both
scabies mites
How can diazinon be neutralized if it gets on the skin
- With soap and water
- With concentrated alcohol
- Both
- None
Flumethrin is effective against
- Phlebotomus spp
- Both
- Varroa destructor
- None
both
How can benzimidazoles be given
- In premix
- In intraruminal bolus
- Both
- None
both
Which statement is true? Usage of ectoparasiticide agents is inevitable because
- Ectoparasites can be vectors, intermediate hosts for other parasites
- Ectoparasites can make anials stressful
- Both
- None
both