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Pharma final written 2nd semester pq > Antibiotics midterm 1 > Flashcards

Antibiotics midterm 1 Flashcards

1
Q

What is the mode of action of pleuromutilins ?
Time-dependant bacteriocidal
Concentration dependent bacteriocidal
None of these
Bacteriostatic

A

Bacteriostatic

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2
Q

Which of the following antibiotics is effective in swine dysentery ?
None of them are effective
Tulathromycin
Tilmicosin
Both are effective

A

none

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3
Q

Which is characteristic of amoxicillin’s distribution Moderate : due to its lipophilicity, it can barely cross special barriers, but it can enter the cells

Moderate : due to its water solubility, it can barely cross special barriers and it can barely enter the cell Moderate : due to its water solubility, it can barely cross special barrier but it can enter the cells

Good : due to its lipophilicity, it can cross special barriers and it can enter the cells

A

B

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4
Q

Which is NOT true for cefalexin ?
It is a first generation cefalosporin
It is concentration dependent bacteriocidal
It has postantibiotics effect
It is not inactivated by ß-lactamase producing Staphylococcus pseudintermedius

A

it is concentrational dependent bacteriocidal

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5
Q

Cefquinome belongs to the …

  1. Generation cephalosporins
  2. Generation cephalosporins
  3. Generation cephalosporins
  4. Generation cephalosporins
A

4 generation cephalosporins

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6
Q

Cefuroxime belongs to the …

  1. Generation cephalosporins
  2. Generation cephalosporins
  3. Generation cephalosporins
  4. Generation cephalosporins
A

2 generation cephaloporins

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7
Q

Which antibiotic is effective against methicillin-resistant Staphylococcus intermedius
infections ?
Amoxicillin clavulonic acid
None of them
Flucloxacillin
Ticarcillin clavulonic acid

A

flucloxacillin

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8
Q

Which combination can lead to decreased efficacy ?
Phenoxymethylpenicillin + florfenicol
Doxycycline + tulathromycin
Amoxicillin + clavulanic acid
Colistin + amoxicillin

A

phenoxymethylpenicillin florfenicol

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9
Q

Risk of selecting resistant bacteria is highest at this antibiotic concentration :
MIC < concentration < MPC
concentration < MIC
concentration > MPC
None of them

A

mic< concentration< mpc

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10
Q

Which aminoglycoside is the most toxic among the followings ?
Spectinomycin
Streptomycin
Neomycin
Amikacin

A

Neomycin

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11
Q

How can azithromycin be administrated ?
Orally
In IM injection
Both
None of them

A

orally

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12
Q

Which substance does NOT belong to the CIA Highest Priority antibiotics category ?
Amoxicillin
Cefquinom
Cefoperazone
Colistin

A

amoxillin

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13
Q

Amoxicillin is active against
Mycoplasma spp
None of them
Pseudomonas spp
Chlamydophila spp

A

none of them

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14
Q

Which statement is NOT true for chloramphenicol ?
It can cause dose-independent aplastic anemia
It belongs to the table 2 (37/2010 EC)
It can be used topically in ophthalmic products
It is effectively used in sheep foot rot

A

it is effectively used in sheep foot rot

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15
Q

What is characteristic to doxycyline’s absorption if given orally ?
Good, food has no effect on it
Good, but it gets worse without food
Bad, therefore they should be given with food
Good, but milk products decrease absorption

A

Good, food has no effect on it

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16
Q

What is the mechanism of action of lincosamides ?
Inhibition of peptidoglycane suynthesis
Inhibition of deoxyribonucleic acid synthesis
Inhibition of protein synthesis on the 30S ribosome subunit
Inhibition of protein synthesis on the 50S ribosome subunit

A

Inhibition of protein synthesis on the 50S ribosome

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17
Q

Cefovecin is NOT effective against :
Mycoplasma spp
None of them
Pseudomonas spp
Mycobacterium spp

A

Mycoplasma spp

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18
Q

Which antibiotic group does NOT belong to the CIA Highest Priority antibiotics category ?
Pleuromutilines
Polymyxines
Fluroquinolones
IV. Generation cephalosporins

A

pleuromutilines

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19
Q

Amoxicillin clavulonic acid is NOT effective in …
Dermatitis in dogs
It’s effective in all of them
Echericha Coli urinary tract infection in dogs
Foot rot

A

its effective in all of them

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20
Q

This cefalasporin is effective in methicillin-resistant Staphylococcus pseudintermedius
infections :
Cefoperazon
Ceftiofur
None of them
Cefadroxil

A

none of them

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21
Q

Which penicillin derivate has the longest half-life ?
Procaine benzylpenicillin
Benzathine benzylpenicillin
Benzylpenicillin sodium
Their half-life is similar

A

Benzathine benzylpenicillin

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22
Q

What is the mechanism of action of aminoglycosides ?
Inhibition of peptidoglycane synthesis
Inhibition of deoxyribonucleic acid synthesis
Inhibition of protein synthesis
None of them

A

Inhibition of protein synthesis

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23
Q

Which is the most toxic macrolide antibiotic ?
Tilmicosin
Tildiprosin
Tilamulin
Tylvalosin

A

tilmicosin

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24
Q

Which of the following antibiotics is effective in swine dysentery ?
Tylvalosin
Tildipirosin
Both of them
None of them

A

Tylvalosin

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25
Q

Clindamycin is eliminated in dogs …
Mostly with urine
Mostly through the colon wall
Mostly with saliva
Mostly with bile

A

mostly with bile

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26
Q

In which of the flowing cases can we expect antagonism generally ?
When combining two 30S protein synthesis inhibitors
When combining two antibiotics with different spectrum
When combining a 30S and 50S synthesis inhibitor
None of them

A

When combining two 30S protein synthesis inhibitors

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27
Q

In which case can Vancomycin be used ?
Dogs with meningitis
Life-threatening pneumonia in a calf
Severe bacterial enteritis in a pig
All of them

A

Severe bacterial enteritis in a pig

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28
Q

What is the mechanism of action of macrolides ?
Inhibition of peptidoglycane synthesis
Inhibition of deoxyribonucleic acid synthesis
Concentration-dependent bacteriocidal
Inhibition of protein synthesis on the 50S ribosome subunit

A

Inhibition of protein synthesis on the 50s ribosome subunit

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29
Q

Lincomycin can be used in …
Strangles in horses
Both of them
None of them
Mycoplasmosis in poultry (if + spectinomycin)

A

None of them

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30
Q

Which of the following antibiotics is effective in swine proliferative enteropathy ?
tylosin
Tulathromycin
Both of them
None of them

A

tylosin

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31
Q

Which enzyme is inhibited by sulphonamides ?
Dihydrofolate reductase
Dihydropteroate synthetase
Tetrahydrofolate reductase
Tetrahydropteroate reductase

A

Dihydropteroate synthetase

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32
Q

What is the mode of action of bacitracin ?
Bacteriostatic
Inhibition of folic acid synthesis
Inhibition of protein synthesis
Bacteriocidal

A

Bacteriocidal

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33
Q

High calcium content in the feed inhibits the action of …
Colistin
Oxytetracycline
None of them
Both of them

A

oxytetracycline

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34
Q

In which of the following cases can we expect additive effect generally ?
When combining two antibiotics with different spectrum
When combining a 30S and a 50S protein synthesis inhibitor
When combining two 30S protein synthesis inhibitors
When combining a bacteriocidal and a bacteriostatic antibiotic

A

when combning two antibiotics with different spectrum

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35
Q

Which combination can lead to antagonisitic effect ?
Tobramycin + metronidazole
Gentamicin + oxytetracycline
Sulfamethoxazole + trimethorpim
All of them

A

Gentamicin + oxytetracycline

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36
Q

What does MIC stand for ?
Minimum inhibitory concentration
Maximum inhibitory concentration
Mean inhibitory concentration
Median inhibitory concentration

A

Minimum inhibitory concetration

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37
Q

Which substance acts against a unique target ?
Dicloaxacillin
Levamisole
Trimethoprime
Diphenhydramine

A

Dicloaxacillin

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38
Q

Which combination can lead to additive effect ?
Ceftiofur + tulathromycin
Metronidazole + gentamicin
Tylosin + tulamycin

A

Metronidazole + gentamicin

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39
Q

Which statement is NOT true for tetracyclines ?
They can cause ulcers in the oesophagus if given rapidely
They can cause cardiovascular problems if given intravenously
They can cause photosensitization
They are highly nephrotoxic due to binding to the kidney cortex

A

They are highly nephrotoxic due to the kidney cortex

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40
Q

Which substance does NOT act against a unique target ?
Levamisole
Flucloxacillin
Phenoxymethylpenicillin
Bacitracin

A

Levamisole

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41
Q

Bacitracin can be given …
Orally
Topically
None of them
Both of them

A

Both of them

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42
Q

Bacitracin can be used against …
Urinary tract infection caused by Escherichia coli
Kennel cough
Proliferative enteropathy
Necrotic enteritis

A

Necrotic enteritis

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43
Q

This/these substance(s) has poor oral bioavailability
Bacitracin
Colistin
Both of them have good bioavailability
Both of them have a poor bioavailability

A

Both of them have a poor bioavailability

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44
Q

Vancomycin is eliminated …
Mostly with the bile
Mostly through the colon’s wall
Mostly with urine
Mostly with saliva

A

mostly with urine

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45
Q

Which side effect can occur during sulphonamide treatment ?
Type III allergic reaction in dogs
Both of them
Vitamin K deficiency in poultry
None of them

A

Both of them

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46
Q

Which agent can be given IV ?
Procaine benzylpenicillin
Benzylpenicillin sodium
Benzathine benzylpenicillin
Amoxicillin trihydrate

A

Benzylpenicillin sodium

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47
Q

Risk of selecting resistant bacteria is lowest at this antibiotic concentration :
concentration > MPC
concentration < MIC
MIC < concentration < MPC
None of them

A

concentration > Mpc

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48
Q

To which antiobiotic category do III and IV generation cephalosporins belong ?
B (restrict)
A (avoid)
C (caution)
D (prudence)

A

B restrict

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49
Q

Which is the aim when ceftiofur is used
The drug concentration should be above MIC as long as possible
The drug concentration should be above MIC as much as possible
Both should be achieved
None of them is true

A

the drug concentration should be above MIC as long as possible

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50
Q

What is the aim when we use concentration dependent antibiotics ?
Giving high dose for a short time
Giving high dose for a long time
Giving low dose for a short time
Giving low dose for a long time

A

Giving high dose for a short time

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51
Q

Which sulphonamide is called “intestinal disinfectant”
Sulfasalazine
Sulfaguanidine
Sulfaquinoxaline
Sulfadimethoxine

A

sulfaguanidine

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52
Q

What is the mode of action of potentatied sulphonamides ?
Concentration-dependent bactericidal
Time-dependent bactericidial
Bacteriostatic
Inhibition of folic acid synthesis

A

time dependent bactericidal

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53
Q

Which enzyme is inhibited by diaminopyrimidines ?
Dihydropteroate synthetase
Dihydrofolate reductase
Tetrahydrofolate reductase
Tetrahydropteroate reductase

A

dihydrofoalte reductase

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54
Q

Dysbiosis is most likely to occur in this species during sulphonamide treatment :
Ruminants
Poultry
Cats
Horses

A

Horses

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55
Q

Which side effect is characteristic of polymixins
Severe liver damage
Severe dysbiosis
All of them
Severe kidney damage

A

severe kidney damage

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56
Q

Which substance has antiendotoxin effect ?
Bacitracin
Both of them
None of them
Polymyxin B

A

Polymyxin B

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57
Q

Tetracyclines can be effective in
Lyme disease
Foot rot
Kennel cough
All of them

A

all of them

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58
Q

Which of the following agents hast postantibiotic effect ?
Phenoxymethylpenicillin
All of them
Cefalexin
Piperacillin

A

all of them

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59
Q

Cefovecin belongs to the …

  1. Generation cefalosporins
  2. Genetarion cefalosporins
  3. Generation cefalosporins
  4. Generation cefalosporins
A

3 generation cefalosporins

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60
Q

Which combination can lead to additive effect ?
Ceftiofur + tulathromycin
Metronidazole + gentamicin
Tylosin + tulathromycin
All of them

A

Metronidazole +gentamycin

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61
Q

Which sulphonamide has relevant coccidiostatic activity ?
Sulfadiazine
Sulfaquinoxaline
Sulfachlorpyridazine
Sulfasalazine

A

sulfaquinoxaline

62
Q

Rifampicin can be used in the following case.
Escherichia coli diarrhea in swine
Kennel cough
Rhodococcus equi infection in horses
Isospora canis nfection in dogs

A

Rhodococcus equi infection in horses

63
Q

This bacterium usually does not produce ß-lactamase enzymes.
Staphylococcus pseudintermedius
Clostridium perfringens
Fusobacterium necrophorum
Porphyromonas levii

A

staphylococcus pseudointermedius

64
Q

Against which type of target do the azoles act ?
Unique target
Similar target
Common target
None of them

A

unique target

65
Q

In which case can we used bacteriostatic agents ?
Middle aged dog, good overall health
Pregnant sow
Cat infected with Feline Leukemia Virus
Old horse

A

middle aged dog, good overall health

66
Q

Generally, therapeutic index of chemotherapeutics is highest if they act against …
Unique target
Similar target
Common target
There’s no difference

A

unique target

67
Q

Generally, therapeutic index of chemotherapeutics is highest if they act against …
Unique target
Similar target
Common target
There’s no difference

A

unique target

68
Q

Which is characteristic to phenicol’s pharamcokinetics ?
Bad, they are not absorbed orally
Good, but they can’t cross the special barriers
None of them
Excellent, they can cross the special barriers and the cell membrane

A

excellent they can cross the special barriers and the cell membrane

69
Q

Which agent can be used in Lawsonia intreacellularis infection ?
Spectinomycin
Both of them
None of them
Lincomycin

A

Both of them

70
Q

What is the combination partner of lincomycin ?
Spiramycin
Streptomycin
Sulbactam
Spectinomycin

A

spectinomycin

71
Q

Inhibition of dihydropteroate-synthetase is a ………….. in antimicrobial therapy
unique target
Similar target
Common target
None of them

A

Unque target

72
Q

Which combination can lead to additive effect ?
Gentamicin + oxytetracycline
Tobramycin + metronidazole
Sulfamethoxazole + trimethoprim
All of them

A

Tobramycin + metronidazole

73
Q

Cefapirin belongs to the …

  1. generation
  2. generation
  3. generation
  4. Genereation
A

1st generation

74
Q

Lincomycin frequently show cross resistance with …
Spectinomycin
Amoxicillin
Sulfadiazine
Tylosin

75
Q

Dicloxacillin is effective in …
E. Coli urinary tract infection in dogs
Streptococcus uberis mastitis in cattle
Footrot
All of them

A

Streptococcus uberis mastitis in cattle

76
Q

What does MBC stand for ?
Minimum bactericidal concentration
Minimum bacteriostatic concentration
Mean bactericidal concentration
Mean bacteriostatic concentration

A

minimum bactericidal concentration

77
Q

Which antibiotic group belongs to the CIA Highest priority antibiotics category ?
III generation cephalosporins
I generation cephalosporins
II generation cephalosporins
Phenicols

A

III generation cepaloporins

78
Q

Lincomycin can be used in …
Swine dysentery
Proliferative enteropathy
None of them
Both of them

A

Both of them

79
Q

Ceftriaxone belongs to the …

  1. generation
  2. generation
  3. generation
  4. Generation
A

3rd generation

80
Q

Amikcain is active against …
Methicillin resistant Staph aureus
Pasteurella multocida
Both of them
None of them

A

both of them

81
Q

Amoxicillin clavulonic acid is effective in …

Dermatitis in dogs

All of them

Streptococcus uberis mastitis in cattle

bite wounds in cats

82
Q

Neomycin is active against …

Clostridium perfringens

Fusobacterium necrophorum

None of them

Both of them

83
Q

Which agent can be used in Bachyspira hyodysenteriae infection ?
Ceftiofur
Both of them
None og them
Tylvalosin

A

Tylvalosin

84
Q

This cephalosporin is effective in methicillin resistant Stpah pseudintermedius infections?
Cefquinome
Ceftriaxone
None of them
Cefovecin

85
Q

Procaine benzylpenicillin is given …
In IV injection
In IM injection
Orally
All of them are correct

A

Im injection

86
Q

There’s NO glycoside bond in the structure of this antibiotic :
Streptomycin
Amikacin
Spectinomycin
All of them have glycoside bonds

A

Spectinomycin

87
Q

Effective against Pseudomonas aeruginosa
Cefalexin
Ceftazidime
Ampicillin + sulbactam
Oxytetracycline

A

Ceftazidime

88
Q

The bacterium doesn’t belong to the fastidious Gram-negative organisms :
Histophilus somni
Pseudomonas aeruginosa
Pasteurella multocida
Mannheimia hemolytica

A

pseudomonas aeruginosa

89
Q

What is the mode of action of ß-lactame antibiotics ?
Concentration-dependent bactericidal
Time dependent bactericidal
Bacteriostatic
Depends on the drug’s concentration

A

Time dependent bactericidal

90
Q

Which combination can lead to decreased efficacy ?
Phenoxymethylpenicillin + florfenicol
Doxycycline + tulathromycin
Amoxicillin + clavulonic acid
Colistin + Amoxicillin

A

Doxycycline +tulathromycin

91
Q

Whcich combination can lead to additive effect ?
Tylosin + Valnemulin
Amikacin + Metronidazole
Lincomycin + Spectinomycin
All of them

A

Lincomycin +spectinomycin

92
Q

Against which type of target do the ß-lactam antibiotics act ?
Unique
Similar
Common
None

93
Q

What is the mode of action of sulphonamides ?
Concentration-dependant bactericidal
Bacteriostatic
Time-dependent bactericidal (if + DAPs)
Inhibition of folic acid synthesis

A

B and maybe c

94
Q

What is the mode of action of vancomycin generally ?
Bacteriostatic
Inhibition of folic acid synthesis
Bacteriocidal
Inhibition of protein synthesis

A

Bacteriocidal

95
Q

What is the mode of action of tetracyclines ?
Time-dependent bactericidal
Concentration-dependent bactericidal
Bacteriostatic
Agent-dependent bactericidal

A

Bacteriostatic

96
Q

Clindamycin can be used in …
Urinary tract infection
Both of them
None of them
Oral cavity infection

A

oral cavity infection

97
Q

What is the mode of action of phenicols
Time-dependent bactericidal
Concentration-dependent bactericidal
Agent-dependent bactericidal
Bacteriostatic

A

Bacteriostatic

98
Q

Florfenicol’s ½ life is the shortest in this species :
Cat
Dog
Swine
Cattle

99
Q

Which mechanism of resistance is characteristics against sulphonamides
Efflux pump
Decreased penetration
Both of them
None of them

A

Decreased penetration

100
Q

This can be an indication of potentiated sulphonamides
Pseudomonas otitis
Babesiosis
Nocardiosis
Heart worm disease

A

Nocardiosis

101
Q

Vancomycin can be effective in this condition.
Pseudomonas aeruginosa infections
Proliferative enteropathy
Methicillin-resistant Staph aureus infection
Lyme disease

A

Methicillin resistant staph aureus infection

102
Q

Most nephrotoxic agent among the listed antibiotics :
Ampicillin
Cefalexin
Amikacin
Ceftiofur

103
Q

Which aminoglycoside is the safest among the followings ?
Tobramycin
Neomycin
Spectinomycin
Streptomycin

A

spectinomycin

104
Q

Which bacterium is ab ovo resistant to ß lactame antibiotics .?
Pseudomonas aeruginosa
Mycoplasma hyopneumoniae
Staph aureus
E. coli

105
Q

Which antibiotic is effective against methicillin resistant Staph pseudintermedius infection ?
Piperacillin
None of them
Cefalexin
Imipenem

106
Q

What is the mode of action of lincosamides ?
Time dependent bactericidal
Concentration dependent bactericidal
None of these
Bacteriostatic

A

Bacteriostatic

107
Q

Amikacin is active against …
Methicillin resistant Staph aureus
Pasteurella
Both of them
None of them

108
Q

It has the shortest half-life from the listed agents :
Ceftiofur crystalline free acid
Ceftiofur sodium
Cefovecin
Ceftiofur hydrochloride

A

Ceftiofur sodium

109
Q

Mucipirocin can be given …
In IV injection
Both of them
None of them
Topically, in ointment

A

Topically in ointment

110
Q

Which side effect is characteristic of tilmicosin ?
Both of them
Tissue irritation
Cardiotoxicity
None of them

111
Q

Phenicols can be used in …
Bovine respiratory disease complex
Aeromonas Salmonidae infection
None of them
Both of them

112
Q

Most effective meningitis from the listed agents :
Amox + calvulonic acid
Ceftriaxone
Cefovecin
Pivampicicillin

A

ceftriaxone

113
Q

Which of the following antibiotics is effectine in swine proliferative enteropathy ?
Both of them
Tylosin
Lincomycin
None of them

114
Q

What is the mechanism of action of phenicols ?
Inhibition of peptidoglycane synthesis
Inhibition of deoxyribonucleic acid synthesis
Inhibition of protein synthesis on the 30S ribosome subunit
Inhibition of protein synthesis on the 50S ribosome subunit

A

Inhibition of protein synthesis on the 50 s ribosome subunit

115
Q

Which combination can lead to decreased efficacy ?
Amox + tetracycline
Spectinomycin + lincomycin
Ampicillin + sulbactam
Streptomycin + benzylpenicillin procaine

A

amox+tetracycline

116
Q

Acetyl-sulpha cyrstals are dissoved in this pH.
Acidic
Alkalic
They can be dissolved on every pH level
Neutral

117
Q

Which agent belongs to glycopeptide antibiotics ?
Valnemulin
Colistin
Vancomycin
Mupirocin

A

Vancomycin

118
Q

Which combination can lead to antagonistic effect?
Amikacin + metronidazole
Tylosin + valnemulin
Lincomycin + spectinomycin
All of them

A

Tylosin+valnemulin

119
Q

Which combination can lead to decreased efficacy ?
Tiamulin + lincomycin
Tobramycin + cefadroxil
Metronidazole + gentamicin
Ceftriaxone + amikacin

A

Tiamulin + lincomycin

120
Q

Which statement is true ?
MBC > MIC
MBC < MPC
MIC > MPC
None of them are correct

121
Q

This side effect is NOT characteristic to phenicols
Dose-dependent anemia
Immunosupression
Tissue irritation
Kidney damage

A

Kidney damage

122
Q

Clindamycin can be used in …
Bite wounds
Toxoplasmosis
None of them
Both of them

A

Bite wounds

123
Q

Which agent can be used in Brachyspira hyodysenteriae infection ?
Ceftiofur
Both
None
Tylvalosin

A

Tylvalosin

124
Q

Which of the following antibiotics is effective in Campylobacter infection in dogs?
Both of them
Clindamycin
Erythromycin
None of them

A

Erythromycin

125
Q

Phenoxymethylpenicillin in NOT effective in …
Tetanus
Dermatitis in dogs
Botulism
Necrotic enteritis in poultry

A

Dermatitis in dogs

126
Q

This can be an indication of potentiated sulphonamides :
Keratoconjunctivits sicca
Toxoplasmosis
Tuberculosis
Botulism

A

Toxoplasmosis

127
Q

Crystalluria is most likely to occur in this species during sulphonamide treatment :
Dogs
Cats
Horses
Sulphonamides can’t cause crystalluria

128
Q

Aminoglycosides are eliminated …
In inactive form, via kidney
In active form, via bile
In active form, via kidney
None of them

A

In active form via kidney

129
Q

How can Tylosin be administrated ?
Both of them
None
Orally
In injection

130
Q

What is the mode of action of rifamycins
Inhibition of protein synthesis
Bacteriostatic
Bactericidal
Inhibition of folic acid synthesis

A

Bactericidal

131
Q

Which side effect can occur during sulphonamide treatment ?
Severe dysbiosis in horses
Irreversible keratoconjunctivitis sicca in dogs
Both
None

132
Q

What is the mechanism of action ß-lactame antibiotics ?
Inhibition of protein synthesis
Inhibition of peptidoglycan synthesis
Inhibition of deoxyribonucleic acid synthesis
None of them are correct

A

Inhibition of peptidoglycan synthesis

133
Q

Phenicols can be used in …
Urinary tract infection
Both
None
Swine respiratory disease complex

A

Swine respiratory disease complex

134
Q

Cefacetril belongs to the …

  1. generation
  2. generation
  3. generation
  4. Generation
A
  1. generation
135
Q

Which statement is true for phenicols ?
They can’t be given to food producing animals because they belong to Table 2
They have narrow spectrum, they are not effective against Pseudomonas
They are eliminated with urine in active form, so they are effective in UTI
Their half-life is different in different species

A

Their half life is different in different species

136
Q

What does MPC stand for ?
Mutant prevention concentration
Minimum preventive concentration
Minimum postantibiotic concentration
Maximum postantibiotic concentration

A

Mutant prevention concentration

137
Q

Aminoglycosides are …
Nephro- and hepatotoxic, and they can cause convulsion
Nephro- and ototoxic, and they can increase the risk of convulsion
Oto- and nephrotoxic, and they can cause paralysis
Oto- and neurotoxic, and they can severely damage the kidneys if administered orally

138
Q

Which agent would you use in a E. coli UTI ?
Phenocymethylpenicillin
Amox
Oxacillin
None of them

139
Q

What is the mechanism of action of lincosamides ?
Time-dependent bactericidal
Inhibition of folic acid synthesis
Cell wall synthesis inhibition
Inhibition of protein synthesis

A

Inhibition of protein synthesis

140
Q

Which of the following antibiotics is effective in Rhodococcus equi infection ?
Erythromycin
Tylosin
Lincomycin
Gentamicin

A

Erythromycin

141
Q

Amoxicillin’s oral distribution is the worst in this species:
Dog
Pig
Chicken
Cat

142
Q

Which statement is false :
MPC > MBC
MBC > MIC
MPC > MIC
MBC > MPC

143
Q

Which substance does NOT belong to the CIA highest priority antibiotics category
Amox
Cequinome
Cefoperazon
Colistin

144
Q

Rifampicin can be used in the following case
Atrophic rhinitis in Su
Lyme disease
Mycobacteriosis
Swine dysentery

A

mycobacteriosis

145
Q

Florenfenicol half-life is longuest in this species :
Dog
Cattle
Swine
Cat

146
Q

Which side effect is not likely to occur during sulfonamide treatment ?
Bone marrow damage
Dysbacteriosis
Allergic reaction
Kidney damage

A

Bone marrow damage

147
Q

Which sulfonamide can be given topically ?
Sulfachlorpyrazine
Sulfadiazine
Sulfasalazine
All of them can be used topically

A

All of them can be used topically

148
Q

What is true about resistance to sulphonamides ?
Resistance is frequent, but it’s only chromosomal
Both chromosomal and plasmid encoded resistance are frequent
Resistance is frequent, but only in plasmid and integron mediated form
Resistance is very rare due to special mechanism of action

A

Both chromosomal and plasmid encoded resistance are frequent

149
Q

This cefalosporin has the best distribution among the listed substances
Cefuroxime
Cefalexin
Ceftriaxone
Cefapirin

A

Ceftriaxone

150
Q

What is the relationship between MIC and MBC values ?
MBC < MIC
MBC < MIC
MB
MIC
Depends on the antibiotic

A

depends on the antibiotic

151
Q

Tildipirosin can reach an effective concentration in the lungs for approximatively

A

14 28 days

Pharma final written 2nd semester pq (2 decks)

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