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Lab Animals > Midterm 1 theory > Flashcards

Midterm 1 theory Flashcards

1
Q

What is the ACC oversee

A

Checks for good animal practice. Checks for the CCAC certification of good animal practice. Enforces the three R program

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2
Q

What are the 3Rs

A

Replacement, refinement, reduction

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3
Q

What does Calas do

A

Improves the standards of practice is enhance animal welfare. Have a national and regional chapter. Also have a registry board exam to be a certified Lab animal technician

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4
Q

What does calam do

A

Concerns veterinarians in lab animal settings

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5
Q

What does aaalac do

A

Similar to CCAC. Accreditation program in the USA. It is international although based in USA

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6
Q

What does aalas do

A

Similar to calas

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7
Q

What does aclam do

A

Similar to calam. For vets

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8
Q

Describe in vitro preclinical testing

A

In cultures

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9
Q

Describe in vivo preclinical testing

A

Preclinical testing on live animals

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10
Q

What is the purpose of preclinical testing

A

Done for safety, efficacy. Required to test on 2 species. Ie: 1 rodent, 1 rabbit

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11
Q

Where do you do new drug submissions in the USA

A

At the fda

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12
Q

Where are the new drug submissions done in Canada

A

Health Canada

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13
Q

What is gcp

A

Good clinical practice

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14
Q

What should the gcp do

A

Should be observed in the conduct of all human drug investigations

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15
Q

What is the first phase of the clinical trial

A

20-100 healthy candidates. Assesses safety and dosage

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16
Q

What is phase 2 of clinical trials

A

On larger groups 20-300. Tested on people who have the disease. Evaluate for side effects and efficacy.

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17
Q

What is phase 3 of the clinical trial

A

Multicenter trials, randomized controlled studies

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18
Q

What happens if phase 1-3 is successful

A

All data is submitted to the regulatory authorities (nds). Once accepted there is still a phase 4

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19
Q

What is phase 4 of the clinical trial

A

Monitoring to check for side effects

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20
Q

What is glp

A

Good laboratory practice relating to non clinical research. Instituted by fda in early 1970. Establishes safety in non clinical studies: food and color additives, drugs, medical devices, pesticides

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21
Q

What does the glp regulate

A

All the methods that must be used to conduct preclinical trials including documentation of data

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22
Q

What is certified food

A

Food is made without contaminates, then checked for metal, antibiotics

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23
Q

Why do we follow glp

A

Assure quality of research for fda.

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24
Q

How do you ensure glp is followed

A

Hire a QA unit to monitor, study, and they report to upper management.

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25
Q

What are the 2 duties of QA

A
  1. Monitor the study to ensure compliance with glp regulations
  2. Perform inspections to ensure compliance with protocol and sop
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26
Q

What is the sop used for

A

Standard operating procedures. We use it to establish consistency

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27
Q

What does the CCAC or or CCPA oversee

A

Oversees the ethical use of animals in science in Canada

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28
Q

What is gnotobiotic

A

All the life is known in these animals

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29
Q

What is axenic

A

Germ free animals

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30
Q

What is defined microbially associated animals

A

Animals injected with specific flora (derived from axenic)

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31
Q

What is barrier maintained animals

A

Free from pathogens: high security

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32
Q

Monitored animals

A

Less rigorous monitoring than barrier maintained, may have some pathogens but no major ones

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33
Q

What is conventional

A

The opposite of gnotobiotic and barrier maintained animals

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34
Q

what is specific pathogen free

A

Not free of all pathogens, just specific ones. Can include vaf. Population is regularly checked to ensure status

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35
Q

What is virus antibody free

A

Free of all viruses

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36
Q

What is outbred stock

A

Avoid inbreeding, mating of individuals as unrelated as possible. Increase heterozygous status. Kept in closed colonies of > 4 generation

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37
Q

What is an inbred strain

A

Minimum of 20 consecutive brother sister matings. Virtually identical to all other of the same strain

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38
Q

F1 hybrid

A

Cross two inbred strains. Goals: known genetics with hybrid strengths

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39
Q

Coisogenic

A

Two strains differing only by one gene. Arise from either a single mutation or by knock out technology. Mutation strain maintained separate from original inbred strain

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40
Q

Congenic

A

Two strains differing only by one gene. Accomplished by breeding rather than as a result of mutation

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41
Q

Transgenic

A

Intentional insertion of dna. To have an animal model to study specific diseases

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42
Q

What is knockout

A

Intentional blockage of a normal gene. Causes a disease to occur

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43
Q

What does a colon mean after the name

A

Means inbred

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44
Q

What does / mean

A

Outbred

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45
Q

What are the short term adverse effects of removing too much blood

A

Hypovolemic shock, long crt, cold extremities, weak pulse, tachycardia

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46
Q

What are long term effects of removing too much blood

A

Anemia (exercise intolerance, pale mm)

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47
Q

How do you calculate estimated circulating blood volume in mice

A

Percent body weight in grams. Equivalents in milliliters per kilogram. Effects of obesity and age. 6% body weight equals 60 ML/KG. BW

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48
Q

What is a safe amount to draw of blood every four weeks

A

15% of body weight

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49
Q

What is a safe amount to draw up of blood every two weeks

A

10% bodyweight

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50
Q

What is the safe amount of blood to draw up every week

A

7.5% of body weight

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51
Q

What is the safe amount of blood to draw up everyday

A

1%

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52
Q

What is the scientific name of the rat

A

Rattus norvegicus

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53
Q

What is the origin of the rat

A

Asia and Europe

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54
Q

What are the outbred stocks of the Rats

A

Wistar, sprague-dawley, long Evans

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55
Q

What are the inbred stocks of the rats

A

Fischer, Lewis, brown Norway, Buffalo

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56
Q

Describe the behaviour of a rat

A

Docile, rarely bites, adaptive to new surroundings, sensitive to sounds, vibrations. Often returns to cage if escapes. Very easily tamed and trained. Rarely fight, coprophagic, nocturnal, burrowing, communal. Omnivores

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57
Q

What is the tail of the rat used for

A

Balance and thermoregulation

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58
Q

Describe the digestive tract of a rat

A

Hind gut fermenter.

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59
Q

What is brown fat used for in the rat

A

Does thermogenesis to produce heat.

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60
Q

What is special about mammary glands in male rats

A

Males have the glands but no nipples

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61
Q

What is the hibernating organ

A

The brown fat between shoulder blades

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62
Q

How many teeth do rats have

A

16

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63
Q

What can rats be a model of with the digestive system

A

Model for tooth decay studies

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64
Q

What are the two portions of a rat stomach

A

Glandular and non glandular

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65
Q

What is the glandular portion of the rats stomach used for

A

Digestion

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66
Q

What is the non glandular portion of the rats stomach for

A

Holds food

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67
Q

What is the stomach fold called in the rats

A

Limiting ridge

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68
Q

Can rats vomit ?

A

No they can’t

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69
Q

What are the three organs of the rats digestive system

A

Caecum, pancreas, liver.

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70
Q

What is special about a rats digestive system ?

A

They don’t have a gallbladder

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71
Q

What is special about a rats heart

A

It has Os Cordis.

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72
Q

What is Os Cordis

A

A bone in the heart around the aortic valve

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73
Q

Describe the female reproductive tract of a rat

A

Bicornate uterus

Vagina is completely superstar from urethra

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74
Q

What are the 6 accessory sex glands in a rat

A 
Preputial glands
Prostate
Vesicular glands 
Coagulating glands 
Bulbourethral glands
Ductus deferens glands
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75
Q

Describe the reproductive tract of the male rat

A

Open inguinal canal. Os penis. Larger genital papilla than female. Multiple accessory glands: 6 types

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76
Q

What does the vesicular and coagulating gland do in males

A

Makes the copulatory plug

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77
Q

What age is sexual maturity of the rat

A

6-8 wk

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78
Q

How long is breeding season for a rat

A

Year long

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79
Q

what is the length of the estrus cycle in a rat

A

4-5 days

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80
Q

How long is estrus in a rat

A

9-20hrs

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81
Q

How long is the duration of gestation in a rat

A

21-23 days

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82
Q

At what age are rats weaned

A

21 days

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83
Q

Is there the whitten effect in rats

A

Yes

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84
Q

Is there the Bruce effect in rats

A

No

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85
Q

How large is the litter size of rats

A

6-12

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86
Q

Describe rats eyes

A

Poor eyesight. No color vision. Harderian gland behind eye gives porphyrin production

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87
Q

Describe the lungs of the rat

A

5 lobes. 4 on right, 1 on left.

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88
Q

Describe the sense of rats

A

Better sense of smell than humans. Hear in ultrasonic range

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89
Q

Describe thermoregulation techniques in a rat

A

They don’t pant. And have no sweat gland

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90
Q

How long is the life span of a rat

A

2.5-3.5yr

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91
Q

What is the scientific name of the mouse

A

Mus musculus

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92
Q

When was the first scientific experimentation on the mouse

A

19th century.

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93
Q

What are the outbred stocks of mouse

A

Swiss, Swiss Webster, institute of cancer research

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94
Q

Describe mice

A

Social. Bite if handled roughly. Fight often. They barber. sensitive to sounds, vibrations. Omnivores

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95
Q

What type of mice have seizures with loud sound

A

Dba mice

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96
Q

Describe mammary glands in female mice

A

5 pairs in females. Have a very extensive distribution on the animal. can often have mammary tumours n

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97
Q

Do mice have sweat glands

A

No

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98
Q

Do mice have a gall bladder

A

Yes they do

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99
Q

Describe spleen size in mice

A

Larger in males than females

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100
Q

Describe the reproductive system of a mouse

A

Bicornuate. Copulatory plug

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101
Q

Describe the male reproductive system of a mouse

A

Open inguinal canal. Os penis. Larger genital papilla. Multiple sex accessory organs

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102
Q

What is the whitten effect

A

Synchronization of females if males is removed

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103
Q

What is the Bruce effect

A

A recently bred female will abort if they smell a strange male

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104
Q

Is the Bruce effect present in mice

A

Yes

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105
Q

Is the whitten effect present in mice

A

Yes

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106
Q

What is the scientific name of the rabbit

A

Ortyctolagus cuniculus

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107
Q

What are the two most popular types of rabbits used for laboratory use

A

New Zealand White

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108
Q

Describe behaviour of rabbits

A

Generally timid, non aggressive. curious bit easily startled. Some aggressive or defensive behaviour. High Pitched scream. Toilet trainable, can be housed together.

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109
Q

What is the dental formula of a rabbit

A

2/1, 0/0, 3/2, 3/3. Malocclusion issues + also need to trim peg teeth.

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110
Q

Describe the stomach of a rabbit

A

Glandular like, cannot vomit.

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111
Q

Describe the cecum of a rabbit

A

extremely important, cecal appendix.

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112
Q

Where is the sacculus rotundus located

A

between the ileum and cecum

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113
Q

What is the sacculus rotundus

A

important lymphoid tissue.

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114
Q

what is the colon

A

has sacculation: groves that increase surface area.

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115
Q

Describe the daytime feces of a rabbit

A

dry. Composition: indigestible fibers

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116
Q

Describe the nighttime feces of a rabbit

A

moist (cecotroph). Composed of B vitamins, water, nitrogen

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117
Q

Describe the urine of rabbits

A

Color variance due to whats eaten. Turbidity is due to high amount of crystals. Alkaline pH.

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118
Q

Describe the muscoskeletal system of a rabbit

A

High amount of muscle mass but very light bones. 7% of BW is skeleton

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119
Q

Describe the mammary glands of rabbits

A

8-10. Distribution: from neck to inguinal region.

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120
Q

Do male rabbits have nipples?

A

No

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121
Q

Describe the eyes of a rabbit

A

Third eyelid is developed. Harderian glands are located behind eyes.

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122
Q

What are the common issues with rabbits eyes

A

Cherry eye

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123
Q

Where is the location of the scent glands in rabbits

A

In inguinal pouch. On either side of vagina/penis.

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124
Q

What is the scent gland used for in the rabbit

A

Used to mark territory.

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125
Q

What else can rabbits used besides the scent glands to mark their territory

A

their chin

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126
Q

What is the dewlap found and what can it cause

A

Mostly in females, can cause moist dermatitis.

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127
Q

What are the functions of the ears

A

thermoregulation (vascular), auditory, sensitive

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128
Q

Describe the Hematopoietic system

A

Neutrophil (psuedoneutrophils or heterophils) (20-35%). Eosinophil: 0-4%

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129
Q

Describe the reproductive system of a female rabbit

A

Bicornuate and double cervix.

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130
Q

Describe the reproductive system of a male rabbit

A

open inguinal canal. Scrotum is cranial to the penis. Testis descend at 12 weeks

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131
Q

Describe the estrus cycle length of a rabbit

A

induced ovulator

132
Q

When is ovulation in a rabbit

A

9-13 hours post coitus (~10hrs)

133
Q

How long is the gestation of the rabbit

A

29-35 days

134
Q

When are rabbits weaned

A

4-6 weeks

135
Q

When do rabbits need to nurse

A

1x/day (3-4 mins/day)

136
Q

What can you use for milk replacement in the rabbit

A

Kitten forumla

137
Q

What is the lifespan of a rabbit

A

5-7 years

138
Q

What is the normal bodyweight of a rabbit (f/m)

A

2-6/2-5kg

139
Q

What is the normal body temperature range for a rabbit

A

38.5-40.0*c

140
Q

What is needed for husbandry of the rabbit

A

need to give food enrichment: greens, hay. Suspended or plastic cages

141
Q

Where are guinea pigs originated

A

south america

142
Q

What are the english variety (outbred)

A

duncan-hartley
hartley
** both albinos

143
Q

What are the abyssinian variety (outbred)

A

short; rough-hair arranged in rosettes

144
Q

what are the peruvian variety (outbred)

A

long hair

145
Q

What are the inbred guinea pigs

A

several strains

146
Q

describe the behavior of guinea pigs

A

docile, rarely bite or scratch, climb + jump rarely. produce a variety of vocalizations. develop rigid habits (that can lead to anorexia), easily excited by noise, changes, coprophagic, communal, messy

147
Q

describe a guinea pigs feet

A

4 toes on forelimb, 3 toes on hindlimb

148
Q

Describe the mammary gland of guinea pigs

A

have only one pair of nipples in inguinal area

mammary tissue only in females

149
Q

how many offspring can a guinea pig nurse at one time

A

2

150
Q

how may pups can a guinea pig have

A

up to 5

151
Q

what are precocious pups

A

can eat right away

152
Q

Describe the oral cavity of a guinea pig

A

dental formula: 1/1, 0/0, 1/1, 3/3
Open rooted and continiously erupt
malocclusion possible with the premolars

153
Q

Describe the stomach of a guinea pig

A

all glandular like rat

154
Q

describe the cecum of the guinea pig

A

very large and located on the left. be careful when doing IP and inject on the right. Divided into pouches

155
Q

describe the colon of the rat

A

very long.allows for better reabsorption of water.

156
Q

describe the auditory system of the rat

A

large tympanic bullae. sx approach easy. sensitive hearing. used in otology research and ototoxicity drugs.

157
Q

describe the respiratory system of the rat

A

bronchioles are extremely reactive: respiratory anaphylaxis

158
Q

describe the hematology of a rat

A

neutrophils: heterophils as in the rabbit
kurloff cells: mononuclear cells; proliferates under the influence of estrogen.
lymphocytes: the majority of WBC

159
Q

Describe the urology of the guinea pig

A

urine is alkaline, opaque, creamy, yellow, and contains crystals

160
Q

what is the lifespan of the guinea pig

A

4-5 yrs

161
Q

what is the normal body weight of a guinea pig. f/m

A

700-900/900-1200g

162
Q

describe the reproductive tract of the female guinea pig (sow)

A

bicornuate uterus
y shaped genital-anal opening
vaginal membrane (opens only during estrus and parturition)

163
Q

Describe the reproductive tract of the male guinea pig (boar)

A

open inguinal canal where testes are located.
os penis
exposed penis has two prongs at tip
several accessory sex glands
large seminal vessicles that extend 10cm into the abdominal cavity from the pubis.

164
Q

What is the estrus cycle length of the guinea pig

A

15-17 days

165
Q

what is the estrus length in the guinea pig

A

8-11hours

166
Q

what is the duration of gestation in a guinea pig

A

59-72 days

167
Q

What is the average litter size of a guinea pig

A

2-5

168
Q

what is the normal weight at birth of a guinea pig

A

70-100g

169
Q

when are guinea pigs weaned

A

14-21d

170
Q

if the sow is to be bred, her first litter has to be when

A

before 7 months

171
Q

how do you house guinea pigs

A

large shoebox cage with bedding (to avoid bumble foot). don’t use cedar bedding due to a reaction, avoid substrate with small particles or dust. change cage often

172
Q

how do you feed guinea pigs

A

GP chow. provide fresh food (vitamin C). J feeders or bowls. Give Vit. C to prevent scurvy. Avoid sudden food changes

173
Q

How do you handle guinea pigs

A

one hand on trunk, one hand on hindquarters. injury to liver and lungs from one handed pressure

174
Q

where do you do IM injections in the guinea pig

A

use the same spots of the rabbit. lumbar, quadricep and caudal thigh

175
Q

where do you do IV injections in the guinea pig

A

saphenous or cephalic

176
Q

how is blood collected from guinea pigs

A

small amount: marginal vein, cephalic, saphenous.

large amount: cranial vena cava, jugular vein, femoral vein, intracardiac (terminal)

177
Q

where do you do your IP injection on the guinea pig

A

on the right side

178
Q

What are the 3 most common types of hamster

A

mesocricetus auratus
cricetus cricetus
cricetulus griseus

179
Q

Where do hamsters originate

A

syria

180
Q

what are the outbred hamster species

A

golden syrian, european hamster, chinese hamster

181
Q

what are the inbred hamster species

A

many have been developed to study specific diseases

182
Q

Describe the behaviour of hamsters

A

nocturnal, female larger and more aggressive than male. bites if handled roughly, suddenly disturbed or when startled. chew on and escape from their cage. ideally housed singly. coprophagic

183
Q

describe the cheek pouches of hamsters

A

highly distensible, devoid of glands and lymphatic tissue, ideal site for tumor induction, transplantation and xenograft

184
Q

what are the problems associated with cheek pouches in hamsters

A

can put pups in cheek and suffocate them. also can impact or get infected

185
Q

what are the hip glands in hamsters

A

in adult male, used for marking, located on either flank

186
Q

Describe the teeth of a hamster

A

1/1, 0/0, 0/0, 3/3. Incisiors grow continually, molars retain food

187
Q

describe the stomach of a hamster

A

divided into two portions, glandular and non glandular. distinct constriction between the two.

188
Q

describe the intestines of a hamster

A

long intestines except the ileum

189
Q

describe the brown fat of a hamster

A

ventral to and between scapula

190
Q

describe the eyes of a hamster

A

also have harderian glands (behind eyeball)

191
Q

describe the kidneys of a hamster

A

extremely long renal papillae that extend into ureter
high urine concentration capacity (1.060) urine is turbid, milky and contains crystals
urine proteins normally present (high levels)

192
Q

What is the lifespan of a hamster

A

18-24m

193
Q

What is the body weight of a hamster

A

95-150/85-130g

194
Q

Describe hibernation in the hamster

A

permissive hibernators. Low environmental temp

195
Q

Describe the reproductive tract of the female hamster

A

bicornuate uterus
6-8 pairs of nipples
three openings in the perineal area
viewed from above, pointy behind

196
Q

describe the reproductive system of the male hamster

A 
open inguinal canal
os penis
large testes and seminal vesicles
two large fat bodies cranial to the testes
viewed from above: rounded behind
197
Q

what is the estrus cycle length of a hamster

A

4 days

198
Q

what is the duration of gestation for a hamster

A

15-16d

199
Q

when are hamsters weaned

A

20-25 days

200
Q

describe the PP estrus in hamsters

A

infertile

201
Q

Describe female hamsters during estrus

A

aggressive toward the male except at the onset of estrus.

202
Q

do hamsters cannibalise their young?

A

yes, cannibalism is common. primiparous female (first litter)

203
Q

Describe newborn hamsters

A

hairless, blind, have closed ears and underdeveloped limbs. pups begin to eat at 7-10d of age

204
Q

how do you house hamsters

A

shoebox cage with bedding. change cage 1x/week

205
Q

how do you provide water for a hamster

A

water bottle or automated system

206
Q

describe using a feeder with a hamster

A

slots of hopper must be large enough.

207
Q

what do you feed hamsters

A

rodent chow: 16% protein minimum (less: alopecia). 4-5% fat

208
Q

how do you handle hamsters

A

picked up in a small container. cupping of hands, scruffing: a lot of loose skin due to cheek pouches

209
Q

what procedures are done on hamsters

A

SC, IM, IP, blood collection

210
Q

describe non terminal blood collection in hamsters

A

jugular, saphenous

211
Q

describe terminal blood collection in hamsters

A

IC under anesthesia

212
Q

where do you do IV injections in the hamster

A

saphenous, cephalic

213
Q

What is the scientific name for a gerbil

A

meriones unguiculatus

214
Q

where do gerbils come from

A

mongolia, siberia, and northeastern china

215
Q

describe the behaviour of a gerbil

A

clean, nearly odorless, burrowing habits: need lots of bedding, active 24hrs a day without being specifically nocturnal. friendly, curious and social in groups. barbering. easy to handle, foot stomp

216
Q

when do gerbils do the foot stomp

A

when fearful, startled, excited
to attract attention or express aggression
after sexual activity

217
Q

describe the tail of a gerbil

A

very thin layer of skin. sloughing, skinless tail then falls off

218
Q

describe the abdominal sebaceous gland pad of the gerbil

A

observed in both sexes, used to mark territory and pups oval in mid-ventral region; covered by darker hair

219
Q

describe the stomach of a gerbil

A

divided into 2 portions

220
Q

describe the dental formula of a gerbil

A

1/1, 0/0, 0/0, 3/3, continuously growing incisiors

221
Q

describe spontaneous convulsive seizures in gerbils

A

similar to idiopathic epilepsy in humans. begins at 2 months of age, occurs in 1/2 of gerbils. elected by stress

222
Q

describe why gerbils are susceptible to strokes

A

incomplete circle of willis

resistant to radiation

223
Q

describe lipemia and hypercholesterolemia in gerbils

A

even on diets with standard fat levels (4-6%). beware of high fat rodent chow (> 6% fat). sunflower seeds, will develop hepatic lipidosis and gall bladder stones

224
Q

what are gerbils used for

A

in the study of lipid metabolism

225
Q

describe the lifespan of a gerbil

A

3-4yrs

226
Q

describe the typical bodyweight of a gerbil f/m

A

55-85g/g6-100g

227
Q

Describe urine and feces production in the gerbil

A

only a few drops of urine are produced a day. dry, small, hard feces. bedding remains odourless for several weeks

228
Q

what is the estrus cycle length of a gerbil

A

4-6d

229
Q

describe the duration of gestation of a gerbil

A

24-20d (up to 42d)

230
Q

when are gerbils weaned

A

20-26d

231
Q

describe the mating system of a gerbil

A

gerbils mate for life (monogamous) - can use harem system/loss of mate.

232
Q

Do male gerbils help take care of their young

A

yes they do.

233
Q

describe housing for a gerbil

A

solid bottom shoe or glass aquarium. secure lid

234
Q

describe bedding for a gerbil

A

thick, hardwood chips, wood shavings, recycled paper pellets and sand. no cedar.

235
Q

what food do gerbils eat

A 
rodent chow (16-22% protein, low fat)
limit sunflower seeds
236
Q

Describe the behaviour of the pig

A

friendly, docile, react poorly to improper handling or stressful conditions. Enjoy regular human interaction

237
Q

what are the medical conditions induced by stress:

A

gastric ulcers.

238
Q

How many different species of pigs are there

A

over 85 different types. farm pigs are large species, but there are also mini and micro pigs

239
Q

describe the hanford (miniature pig)

A

white skin, very little fat. heart size is similar to humans. adult weight 70-90kg

240
Q

describe the yucatan pig

A

dark pigmented skin, little or no hair. docile: easy to handle. Ventricular septum defect line. available. adult weight: 70-90kg

241
Q

describe the gottingen pig

A

comparable size to micro pig. very well defined genetics. adult weight: 35-40kg

242
Q

Describe the sinclair pig

A

from four feral breeds. different hair colors. slower growth rate. unique model for melanoma. 35-55kg

243
Q

what are the other types of pigs available

A

micro pig: from selective breeding of yucatan pig males =/- 50kg, female +/- 40kg
also SPF, germ free, transgenic

244
Q

What types of pigs do suppliers sell

A

random bred and purpose bred pigs

245
Q

describe the advantage to purpose bred pigs

A

you have all the records + better quality animals

246
Q

describe purpose bred pigs

A

sinclair, gottingen etc. a company that makes specific breeds

247
Q

why do we use purpose bred pigs in the lab

A

valuable model: similar heart and skin to humans. Pigs are used in cardiovascular, integumentary, immunologic studies, agriculture and vet research.

248
Q

What is the advantage of using mini/micro pigs

A

smaller and more manageable.

249
Q

what is the disadvantage of using mini/micro pigs

A

more $$$$$

250
Q

describe the housing for pigs

A

bedding. if compatible: place them together.

251
Q

Describe enrichment for pigs

A

treats, suspended things with a chain: i.e.: basketball

252
Q

Describe bedding for pigs

A

pigs are rooters and like to be clean. solid textured floor. deep bedding. they like to urinate and defecate where it is damp. put water on one side, and food on the other.

253
Q

describe food for pigs

A

pigs are omnivorous. Eat pig chow. do not overfeed. do not fatten up mini pig

254
Q

describe water for pigs

A

need to be clean and always available. dehydration and can get salt poisoning. Can use an automatic watering system or a trough

255
Q

what are the restraint methods for pigs

A

gentle handling to avoid stress, panepinto sling

256
Q

how do you orally dose a pig

A

gavage, PO

257
Q

how do you give an iv injection to a pig

A

inject into the medial auricular vein, lateral auricular vein

258
Q

how do you do blood sampling in a pig

A

in the cranial vena cava, jugular, ear veins.

259
Q

where do you do IM injections in the pig

A

neck, caudal thigh (use long needle)

260
Q

describe anesthesia for pigs

A

12hr fasting. water not restricted unless surgery on stomach

261
Q

describe ET tube intubation in pigs

A

can have laryngospasm. intubation on ventral or dorsal recumbency.

262
Q

describe surgical monitoring in the pig

A

jaw tone, toe pinch, HR, BP, RR

263
Q

what tranquilizers/anticholinergics do you use in the pig

A

ace, atropine, glyco

264
Q

what anesthetics can you use in the pig

A

ketamine, dexmedetomidine, barbituates, propofol, isoflurane

265
Q

what analgesia can you use in the pig

A

opioids (butorphanol, buprenorphine, oxymorphone). NSAIDS (meloxicam, carprofen)

266
Q

describe the history of the use of dogs in research

A

less than 1% of research yet still vital. more difficult for the public to accept. was the most common one used in the 17th century due to availability and ease of handling. 1st successful kidney transplant was on dogs.
creation and testing of artificial hips and joints, and pacemakers. using dogs the heart and lung machine was developed.

267
Q

describe the use of dogs in research

A

cardiovascular and respiratory system. similar to humans and good size to work with. cataract research,
toxicology
dog diseases, nutrition, behaviour and surgical procedures, also diabetes: lupus, thyroiditis, hepatitis

268
Q

what are the types and sources of dogs used in research

A

random source,

purpose bred for research

269
Q

How are random source dogs obtained

A

from licenced vendors, or from pound. cheaper but no medical history is known.

270
Q

how are random source dogs conditioned

A

been through quarantine and conditioning to be more stable.

271
Q

what are the typical dogs theatre purpose bred for research

A 
beagles,
labradors
mongrels (hound type)
272
Q

what is there advantage to purpose bred dogs

A

uniform population

273
Q

what is the disadvantage of purpose bred dogs

A

$$$$$

274
Q

what is the goal of quarantine of dogs

A

to prevent cross contamination

275
Q

how do you quarantine/condition dogs

A

gpe, bw, id, heath record, vaccination, parasite tx/prevention, lab testing, bw monitoring, daily observation

276
Q

how do you house dogs

A

many variations. ensure that lower ranking dogs always have sleeping/ hiding places, food, water. or group singly.

277
Q

how do you socialize dogs and when is the optimal period

A

give them human/animal interaction between 4-14 weeks of age

278
Q

is exercise manditory in a dog

A

yes

279
Q

describe the use of cats in research

A

similar anatomy and biochem of the brain to human. auditory disorders, eye research, leukaemia. FIV: one of the few that develops immune deficiency syndrome. Glowing transgenic cats. Toxoplasmosis, mammary, cancer, cat disease, nutrition and behaviour

280
Q

what are the type and source of cats used in research

A

random, conditioned and purpose bred. purpose bred: referred to as SPF cats

281
Q

how do you house cats

A

in groups if possible. must have sufficient space, shelves, litter boxes, food and water bowls. If small cage: need an exercise pen.

282
Q

what enrichment do you use for cats

A

scratching, rolling toys, vertical space

283
Q

what happens to cats in poor housing conditions

A

become inactive and stop normal behaviours

284
Q

what are the uses of ferrets in research

A

influeza, distemper, GI ulcers, endocrinology, toxicology, cystic fibrosis: similarity between ferrets and humans in lung anatomy, lung cell biology and response to certain lung pathogens

285
Q

where are ferrets for lab use obtained from

A

sold as research animals

286
Q

what do you do in quarentine for ferrets

A

must be vaccinated against distemper

287
Q

describe new world monkeys (platyrrhine):

A

absence of ischial callosities
absence of cheek pouches
prehensile tail in some species
nasal orifices wide apart

288
Q

describe old world monkeys (catarrhine)

A

ischial callosities in some species
cheek pouches in some species
absence of prehensile tail
nasal orifices close together

289
Q

List out the new world monkeys

A 
squirrel monkey - salmiri sciureus
capuchin monkey - cebus apella
common marmoset - callithrix jaccus
golden lion tamarin
owl monkey
290
Q

list out the old world monkeys

A 
african green monkey - cercopithecus aethiops
pats monkey - erythrocebus patas
baboon - patio
rhesus monkey - macaca mulatta
cynomolgus monkey - macaque fascicularis
pigtail monkey - macaca nemestrina
stumptail monkey
291
Q

describe the anatomy characteristics of monkeys

A

great strength and agility. cheek pouches in some old world species, sex skin around genital, tails and thighs in some old world species (skin is red + swollen in estrus)
ischial callosities in some old world species (butt callous)
large canine teeth in males of some species
simple type uterus
all old world primates have menstrual bleeding as a feature of the sex cycle

292
Q

describe the social behaviour of a monkey

A

don’t stare a monkey in the eye. fear smiles: sign of submission. groom each other to establish social bond

293
Q

describe the use of cattle in research

A

used in many argricultural and veterinary research institutes for teaching and research on beef and dairy production and husbandry. used for cardiovascular surgeries.

294
Q

where are cattle supplied from for research

A

established breeder who has healthy, disease free and genetically defined animals, public market, breeding at the research place

295
Q

what are the disadvantages to public markets selling cows

A

no history, stressed, exposed to infectious agents

296
Q

describe the quarantine and conditioning period for cows

A 
lasts 2-4 weeks
GPE
BW
id
observation
fecal, deworming
vaccines (e coli, BVD, IBR, lepto)
297
Q

describe routine health maintence of cattle

A 
daily observation
bw monitoring
fecal, deworming
vaccination
feed + water intake monitoring
trimming of feet
298
Q

describe the use of sheep and goats as lab animals

A 
\:used for cardiovascular and respiratory systems research.
\:orthopedic research
\:production of antiserum
\:reproductive studies
\:transgenic
\:agricultural and vet. research
299
Q

why are goats/sheeps used for cardiovascular and resp. systems research

A

similar anatomy to humans

good for development of surgery procedures, heart valve replacement

300
Q

why are goats/sheeps used for orthopaedic research

A

trauma research, models for disease: injury to bones, joints and muscles
osteoporosis + osteoarthritis

301
Q

why are goats/sheeps used for production of antiserum

A

polyclonal antibodies

sheep rbc: immunologic tests. blood transfusion research

302
Q

why are goats/sheeps used for reproductive studies

A

model for human pregnancy

study of PDA

303
Q

why are goats/sheeps used for transgenic studies

A

production of goat milk antithrombin
production of F VIII + IX to treat hemophilia (sheep milk)
production of AAT to prevent emphysema (sheep milk)

304
Q

describe quarentine/conditioning/routine health maintence of goats/sheep

A

refer to cattle. group housing is preferable.

305
Q

describe q fever

A

rickettsial infection.

306
Q

how is q fever transmitted

A

inhalation, ingestion, direct contact with reproductive fluids or placenta. also shed in milk, urine and feces. ticks may transmit it.

307
Q

describe the zoonosis version of q fever

A

influenza like
chronic problems
DX: serology
TX: antibiotic

308
Q

how do you prevent q fever

A

hygiene, protection, pasteurize milk, vaccination of humans and animals

309
Q

describe anesthesia in cattle

A

ET tube intubation, then stomach tube due to gas build up in rumen

310
Q

how do you recover a cow for surgery

A

keep ET tube in and inflated as long as possible, support animal in sternal. check for bloat

311
Q

how long do you fast a cow before surgery

A

food: 24-48hr
Water: 12-24hr

312
Q

when do you give opioids to a cow

A

pre/post op

313
Q

when do you give xylazine/diazepam to cow

A

pre-anesthetic

314
Q

when do you give xylazine/ketamine/barbituate/propofol

A

for iv induction followed by intubation for inhalant agent

315
Q

where do you give SQ in a cow

A

neck, flank, axillary area

316
Q

where do you do IM in a cow

A

neck, quadriceps, triceps

317
Q

where do you do IV in a cow

A

jugular, cephalic

318
Q

why do we use fish in research

A

aquaculture (food)
environmental pollution indicator
conserv and protect
transgenic

319
Q

what do we use fish to study in research

A 
type 1 diabetes
oncology
kidney studies
genetics
toxicology
mutagenesis
320
Q

where are the fish procured from for research

A

wild caught, captive bred

321
Q

how do you transport fish

A 
plastic bag
cool water
insulated container
opaque container
12-48hr fasting before transport
322
Q

how do you acclimate a fish

A

30d min. separation of new batch from established one
separate water supply
separate equipment
daily observation

323
Q

what do healthy fish look like

A 
good color
well finned
no lesions
opercula covers gills
alert, interested in food
324
Q

what temperature do you keep fish at

A

cold species: 0-10,
cool species: 10-20
warm species: 20-30

325
Q

what does high fish water temp cause

A

ammonia build up

326
Q

what are the signs of insufficient level of oxygen

A

gasping at surface

gather at fresh water intake

Lab Animals (7 decks)

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