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Biology 1104 > Midterm 1 > Flashcards

Midterm 1 Flashcards

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1
Q

Who does evolution work in and when does it not occur?

A

Works on a population of individuals

If the alleles are the same as the original population then evolution doesn’t occur

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2
Q

Define macroevolution

A

Change of allelic frequencies from one generation to the next that ultimately leads to reproductive isolation

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3
Q

When does a new species occur?

A

When two populations are sufficiently different that they can no longer reproduce

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4
Q

What is evolution impossible without genetic variation?

A

Without genetic variation, allelic frequencies will be constant and therefore no microevolution occurs

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5
Q

What are the two types of genetic variation?

A

Discrete (polymorphism)

Quantitative

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6
Q

Define heterozygosity

A

A population measure of genetic diversity at a single locus (2pq)

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7
Q

What is the problem with looking at heterozygosity in a single allele?

A

Does not accurately represent genetic diversity for all loci in a species

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8
Q

Define species heterozygosity

A

Estimate of the genetic diversity across all the loci in a genome

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9
Q

What is the average heterozygosity?

A

Heterozygosity averaged over a random sample of many loci

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10
Q

What is the allelic diversity?

A

A population measure average number of alleles per locus

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11
Q

Where does genetic variation come from?

A

Mutations
Chromosomal changes
Sexual reproduction

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12
Q

How do mutations affect genetic variation?

A

Mutations create new genetic variation creating heritable changes in the DNA if occurring in the gametes
Can be lethal, neutral, deleterious, or advantageous

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13
Q

Describe chromosomal changes

A

Includes inversions, translocations, deletions, fusions, and duplications

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14
Q

Give an example of fusion

A

Chromosome 2 in humans is remarkable similar to chromosomes 12 and 13 in chimps and gorillas, suggesting that it arised from the fusion of the two

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15
Q

How does sexual reproduction effect genetic variation?

A

Meiosis recombination/crossing over
Independent assortment
Fertilization

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16
Q

What is assumed in the hardy-Weinberg equilibrium?

A
  1. No mutations
  2. No immigration
  3. Large population size
  4. All genotypes have equal fitness
  5. Random mating occurs
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17
Q

What occurs when mating is random with no evolutionary forces?

A

Allele frequencies (p&q) stay the same from one generation to the next

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18
Q

What is the hardy-Weinberg equation?

A

(p+q)^2 = p^2 + 2pq + q^2

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19
Q

What is the fitness of a genotype?

A

The ability of a genotype to be passed on during reproduction

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20
Q

What are the mechanisms that cause evolution?

A 
Mutations
Gene flow
Genetic drift
Natural selection
Non random mating/inbreeding
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21
Q

What is gene flow?

A

New things entering a population

Individuals entering a population with new genes

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22
Q

Why is gene flow important?

A

The idea of managing gene flow is critical to endangered species and fragmented habituated
Fragmented habitats stop gene flow and cause extinction to occur faster

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23
Q

What does genetic drift do?

A

Reduces the genetic variability
In small populations random selection leads to genetic drift which leads to a loss of genetic diversity and fixation of alleles
Causes the loss of alleles from generation to generation

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24
Q

What is the founder effect?

A

A small number of individuals leave and begin a new population
There founding populations are small and result in the loss of genetics

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25
Q

What is a population bottleneck?

A

A large portion of the population is killed off resulting in lower genetic diversity

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26
Q

What is currently happening to genetic frequencies?

A

Genetic frequencies are drifting to dominance and loss of alleles resulting in homozygousity

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27
Q

Describe natural selection

A

The favouring of some phenotypes over others

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28
Q

Describe how coral reproduces

A

Sperm and eggs float to surface and are swept out to the ocean and settle down

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29
Q

What causes natural selection?

A

Changing environmental pressures
The phenotype that is more relatively fit leave more offspring
Causes a gradual change in population phenotypes from one generation to the next

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30
Q

Give an example of natural selection

A

The lion fish was accidentally introduced into the carribian by aquariums and devestated the fish population
Those fish with a more cryptic phenotype will have higher reproductive success

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31
Q

Give an example of non random breeding/inbreeding

A

In 1987 there was 27 condors remaining so serious captive breeding programs were initiated
Today there is 425 condors
However one condor had a mutation that caused chicks to die leading to serious effects on the breeding program
This caused a lose of herterozygosity

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32
Q

How do you measure the inbreeding coefficient?

A

F = 1- H(observed)/H(expected)

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33
Q

What is the equation of the pedigree path analysis?

A

F = E(1/2)^n(1 + F)

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34
Q

Is evolution by natural selection random?

A

No it is not random but a consequence of differential survival and reproductive success of individuals within a population - relative fitness

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35
Q

Describe adaptive evolution

A 
Acts on the phenotype
Reduces genetic variation but seldom seen because of diploidy and balancing selection  
Three types: 
1. Directional 
2. Stabilizing
3. Disruptive
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36
Q

Define microevolution

A

Change of allelic frequencies from one generation to the next

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37
Q

What is directional evolution? Give an example

A

Gradual shift of a phenotype in one direction
The average age of maturity in cod in Newfoundland had shifted as they need to reproduce earlier in order to keep up with the fishing

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38
Q

What is stabilizing evolution? Give an example

A

Gradual lose of an outside phenotype

Wild beast in Africa all give birth in the same week. This allows a larger number to survive as the predators are full

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39
Q

What is disruptive evolution?

A

Separates phenotypes
Polar bears and grizzly bears are the same species with different phenotypes
Can produce fertile pizzly bears

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40
Q

Give an example of diploidy

A

HFE gene chromosome 6
A single point mutation causes the autosomal recessive disorder, haemochromatosis
Accelerates the rate of intestinal iron absorption and progressive iron deposition
Cirrhosis of liver, diabetes, testicular failure, cardiomyopathy
10% of Celtic British and scandanavian are carriers, 1% suffer

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41
Q

Describe balancing selection

A

Natural selection favouring balanced polymorphism

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42
Q

What is balanced polymorphism?

A

Two or more phenotypes maintained in stable proportions over many generations
Generally occurs when natural selection favours heterozygotes (sickle cell), different alleles favoured in different environments (snails), frequency dependent selection (fish eating bugs)

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43
Q

Why is no organism perfectly adapted to it’s environment?

A
  1. Natural selection can only act on existing variations
  2. Evolution is limited by historical constraints
  3. Adaptations are often compromised
  4. Chance, natural selection, and environment interact
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44
Q

What are the 4 different definitions of a species?

A

Morphological
Ecological
Biological
Phylogenetic

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45
Q

Define a morphological species and give an example

A

Are distinct in structure and form from other groups
Practical for fossil record, and popular field guides
Ex. Pillar, maze, and boulder brain coral

46
Q

Define ecologic species and give an example

A

Share distinct resources, share the same niche
Relevant towards ecosystem modelling
Play same ecological role
Ex. Lions and tigers

47
Q

Define biological species and give an example

A

Actually or potentially interbreed in nature, producing fertile offspring
Ex. W and E meadowlarks are separated by the Mississippi River and have different songs

48
Q

Define a phylogenetic species

A

Share the tip of a phylogeny, that is, the smallest set of organisms that share an ancestor and can be distinguished from other such sets

49
Q

What is reproductive isolation?

A

An accumulation of genetic differences that ultimately prevent gene pools from two species from mixing
Prezygotic mechanisms
Postzygotic mechanisms

50
Q

What are the Prezygotic mechanisms of reproductive isolation?

A
  1. Habitat/ecological - species live in different ecological niches
  2. Temporal - species breed at different times
  3. Behavioural - species differ in their communications
  4. Mechanical - species differ in their copulatory mechanics
  5. Gamete - species have different receptor proteins
51
Q

What are the postzygotic mechanisms?

A
  1. Reduced hybrid viability - developing fetus aborted
  2. Reduced hybrid fertility - do not produce fertile offspring
  3. Hybrid breakdown - reduced viability
52
Q

What are some problems with the biological species concept?

A

Androdioecous populations
Gynogenetic populations
Hybrid populations
Ring populations

53
Q

What is an androdioecous population?

A

Almost every individual is a hemaphrodyte and can self fertilize
Advantageous when living in an environment when interactions with your own species is low
Ex. Mangrove killifish

54
Q

What is a gynogenetic population?

A

All females
Produce 2N diploid eggs
Require sperm from a different species to stimulate egg development
Ex. Amazon Molly

55
Q

What is a hybrid population?

A

Two species interbreed producing fertile offspring

Ex. Red wolf

56
Q

What is a ring population?

A

Can interbreed with neighbours but not at extreme ends

Ex. Salamanders in California came down from the north and split and therefore can’t reproduce at the southern end

57
Q

What is a subspecies?

A

Population groups within a species
Share unique geographic range/habitat
Distinguishable from other subdivisions in genetically based traits
Do not exhibit marked reproductive isolation
Considered populations partway through evolutionary process of divergence towards full speciation
Ex. Rock wallabies

58
Q

What is speciation?

A

Bifurcation of an ancestral species into two species

Allopatric, parapatric and sympatic

59
Q

What is Allopatric speciation?

A

A) two populations become geographically separated preventing gene flow between them
B) small population becomes isolated at edge of species geographical range (peripatric)
Both undergo their own mutations, natural selection, and genetic drift

60
Q

What is an example of Allopatric speciation?

A

Reed butterfly and lined butterfly fishes

61
Q

Explain an example of secondary contact

A

Reed and lined butterfly fish in the Panama Canal
If it had been built as a trench like the French the fish would have created a hybrid zone and be able to travel across to either ocean

62
Q

What is parapatric speciation?

A

Population spread over discontinuity of environmental conditions
Natural selection may select different asks on either side
Ex polar bear and grizzly bears

63
Q

What is sympatic speciation?

A

New species formed from within range of a population, independent of geographic or environmental gradient
Ex. Hawthorn flies and apple flies

64
Q

How does sympatic speciation occur?

A

Habitat differentiation
Polyploidy
Sexual selection

65
Q

What is polyploidy and what are the types?

A

2N sets of chromosomes
Autopolyploidy (self) - errors in mitosis/meiosis lead to gametes with same number of chromosomes as somatic cells
Allopoluploidy (closely related species hybridize) - initially sterile but may be able to propogate asexually. Later generations can change into fertile polyploidy. Fertile with each other but cannot breed with either parent

66
Q

Why is hybridiAtion bad?

A

Competition between different genotypes within an organism compromises cell cooperation and decreases overall fitness
Highly differentiated unitary animals depend on the full functioning of all their body parts
Any loss of function in a limb or organ will always lead to decreased fitness if not death

67
Q

When is hybridization a good thing?

A

A) colonial/modular organisms where intra-individual genetic variability may be beneficial
B) reticulate evolution

68
Q

Give an example of colonial/modular organisms

A

Coral chimera - a single organism that contains two or more distinct cell lineages from different genetic origins, in short intracolonial genetic variability
Fusion of closely settling larvae
Increase competitive strength of early developmental stages
Or come into contact through growth providing better adaptive abilities to stresses and diversifies gene pool of consecutive generation

69
Q

What is reticulate evolution?

A

Formation of new lineage through partial merging of two ancestor lineages
Not reproductively isolated but may appear morphological my distinct of seperated depending on the packaged genes
Genetic info is repackages into differenent species at different times

70
Q

What is syngameon?

A

All members able to share genetic flow according to reticulate evolution

71
Q

What are the steps to biological research?

A
  1. Objective and research hypothesis
  2. Data collection: experimental design and sampling strategy, relevant to null hypothesis
  3. Analysis: statistic (test null hypothesis), generate meaningful results
  4. Interpretation and synthesis: context of current literature, present efforts in a meaningful way
72
Q

What’s involved in analysis?

A

Types of data, graphing, statistics

73
Q

What are the different types of data?

A
  1. A) groups (nominal) and counts
    B) groups (ordinal) and counts
  2. Groups and measures
  3. Measures and measures
74
Q

What are the different types of graphs?

A
  1. T-test: Comparing averages
  2. Correlation, regression: Comparing correlation between variables
  3. Chi-squared: Associations between groups
  4. Logistical regression
75
Q

What is a null hypothesis?

A

A hypothesis of essentially no difference (no correlation, relationship, or association)

76
Q

What is the signal and variation for the first 3 graphs?

A
  1. T-test: s - difference between the means
    V - scatter around these means
  2. Correlation, regression: s - sims of squares regression
    V - sum of squares residual
  3. Chi-squared: s - difference between observed and expected
    V- expected values
77
Q

When do you reject the null hypothesis?

A

When the chance of making a mistake is less than 5%

78
Q

What did galenus do?

A

Combined philosophical work of Aristotle with own experience of animal dissection
Explain structure and function of human body

79
Q

Who discovered galenus was wrong?

A

Vesalius
Realized he was wrong on many anatomical issues
Introduced comparative anatomy
Realized humans are one species among many, with a few unique traits with many shared in common

80
Q

What did Lamarck do?

A

Suggested life was not fixed
Principle of use and disuse: body parts grow in proportion to amount used
Inheritance of acquired characteristics: changes acquired during life passed in to next generation

81
Q

What did Cuvier do?

A

Studied elephant fossils near Paris
Declared separate species that had vanished
Challenged idea that all gods creatures are alive

82
Q

What did Hutton and Lyell do?

A

Proposed earth was much older than previously believed due to erosion and seabed movement

83
Q

What did Malthus do?

A

Realized that populations can increase geometrically, are capable of unlimited growh, but constrained due to lack of food

84
Q

What did Darwin propose?

A

Individuals within population naturally vary
Artificial selection
In a limited situation those with better suited traits are more likely to leave offspring
If hereditary, becomes more dominant in next generations (natural selection)
What was good in one situation might not be in another

85
Q

What are some misconceptions about evolution?

A
  1. Theory of the origin of life
  2. Like climbing a ladder of progress, organisms are always getting better
  3. Evolution means that life changes randomly
  4. Natural selection involves organisms trying to adapt
  5. Natural selection gives organisms what they need
  6. Evolution is just a theory
86
Q

What are the different types of lines of evidence?

A 
Direct observation
Homology
Fossil record
Biogeography
Pre-adaptations
Allometric growth
Hererochrony 
Evo-Devo
87
Q

What is direct observations? Give an example.

A

Visible evolutionary changes and effects
Ex. Pesticide resistance
More people than food due to soil erosion, salinization, eutrophication
Challenge is to increase agricultural output, maintain soil coverage, and decrease agricultural loss from pest, disease, poor soil, and frost

88
Q

Describe the evolution of pesticides

A
  1. Toxic heavy metals: 97% effective in early 1900s but only 3% by 1930. Also accumulates in soils, inhibits plant growth, and poisons stuff
  2. Organochlorines: Paul muller tested org-chemicals for effect on insects and identified chlorinated hydrocarbons. Needed 1kg in 1946 for 60000 bushels, 64kg in 1971
89
Q

What is the pesticide treadmill?

A

Pest problem - broad spectrum and persistent organochlorines - does not eradicate all but increases resistance - resurgence and secondary outbreaks - new and large quantities of chemicals used - repeat from 3

90
Q

What is homologous?

A

Parallels found in bone structure that are used for different functions

91
Q

What is the fossil record used for?

A

Used to support predictions

Ex. Pakicetus described as an early ancestor of modern whales

92
Q

What is biogeography?

A

Looking at plate movement and thrusts to determine where fossils might be
Ex. Horses originated in North America around 50 million years ago. No way to move to different continent. Eventually connected and horses could move to South America across panama and to Europe across ice

93
Q

What is pre-adaption?

A

A character of an organism that takes on a function when none previously existed it that differs from its existing function which has been derived from evolution
Ex. Feathers for flight

94
Q

What is allometric growth?

A

Evolutionary process when differences in rates of growth lead to divergent species groups
Reflect changes in one or a few genes that regulate patterns of growth
Ex. Homologous structures

95
Q

What is heterochromy?

A

Evolutionary processes where differences in timing of developmental events leads to divergent species groups
Ex. Pedomophorsis

96
Q

Define pedimorphosis

A

Adults retaining juvenile characteristics

Ex. Axolotls

97
Q

What is Evo-Devo?

A

Asks how evolutionary changes in genes regulating embryonic development can lead to changes in body shape and form
Ex. Hox genes: different Hox genes regulate development in different areas of the developing embryo along the head to tail axis

98
Q

Define taxonomy

A

Identification and naming species placing species in hierarchical classifications that reflect their morphological relatedness to each other

99
Q

Define phylogenetics

A

Formal hypotheses identifying evolutionary relationship between species

100
Q

Give the taxonomic classifications

A 
Domain
Kingdom
Phylum
Class
Order
Family 
Genus 
Species
101
Q

What is the problem with taxonomic classification?

A

Mixes apples with oranges
Mixes morphological characteristics with some evolutionary characteristics
No bearing to evolutionary relationship between species

102
Q

What are phylogenetic classifications based on?

A

Karyotypes, physiology, sub cellular structures, protein structures, nucleotide sequences, embryo logical histories, homologous characters vs analogous characteristics

103
Q

What are cladistics?

A

Process to build a phylogenetic tree based on derived characteristics only
Length of tree branches relative only

104
Q

What is the difference between a cladogram and a phylogram?

A

Cladogram doesn’t show timing

105
Q

Give an example of when a phylogram was used to help a species

A

Norfolk Island boobook owl in 1986 was down to single female
Had to cross with most closely related sub-species
Constructed mitochondrial based phylogenetic tree because it is a direct measurement of phylogenetic relatedness
Found closest relative was New Zealand boobook
Have a hybrid population today

106
Q

What are some goals of conservation genetics?

A

Use genetic and evolutionary theory to reduce risk of extinction in threatened species
Minimize loss of genetic diversity
Minimize deleterious effects of inbreeding depression

107
Q

What are the 5 questions asked to determine if genetic management is required?

A
  1. How large is the effective(breeding) population?
  2. Has the population experienced a significant bottleneck?
  3. Has the population lost genetic diversity?
  4. Is the population suffering from inbreeding depression?
  5. Is the population genetically fragmented?
108
Q

Give an example of a fragmented population

A

Red-cockaded woodpecker
Lives in long leaf pine forests
Builds nests in trees that we are now cutting down
Have to determine whether to manage seperately or together

109
Q

How do you determine the answers to the five questions?

A
  1. Population census and basic ecology
  2. Historical records
  3. Direct: gel electrophoresis
    Indirect: Ht/Ho = (1- (1/2Ne))^t
  4. Direct: sperm count, basic ecol.
    Indirect: Ft=1-(1-(1/2Ne))^t
  5. Nei’s index of genetic distance
110
Q

What is neis index of genetic similarity and distance?

A

In=(differenent allele frequencies multiplied)/((total squared allele frequencies pop. 1)(total squared allele frequencies pop.2)^-2)
Distance:
Dn = -ln(In)

111
Q

How big do populations have to be for the 3 different goals?

A

Avoid inbreeding depression = 50
Retain single locus genetic diversity = 500-5000
Retain evolutionary potential = 10^5 - 10^6

Biology 1104 (3 decks)

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