Microtubules

Question 1

MTOC

Answer 1

Microtubule organizing center. Pair of centrioles and proteins that organize MT network

Question 2

Gamma-Tubulin rings

Answer 2

(Nucleating proteins)Nucleate MT elongation and growth outward from cytocentrum. - end of MT in MTOC, + end extends into periphery

Question 3

Capping proteins

Answer 3

Bind to - end of MT

Question 4

Alpha/Beta Tubulin

Answer 4

Form Heterodimers responsible for MT growth. 1 Heterodimer binds GTP, newly added HD’s form GTP-cap on + end

Question 5

MAPs

Answer 5

MT-Associated proteins

Question 6

Nucleating proteins

Answer 6

Gamma tubulin rings

Question 7

Capping proteins (MT associated protein)

Answer 7

These exists

Question 8

Side-binding proteins

Answer 8

Tau and MAP2 bind to side of MT and stabilize/destabilize, cover/uncover (tropomyosin covering myosin). Acts as molecular ruler.

Question 9

Motor Proteins

Answer 9

Kinesins & dyneins are ATPases that move along MT track. Kinesins move cargo toward + end of MT track. Dynesins move cargo toward - end.