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Micro Anatomy > Microfilaments > Flashcards

Microfilaments Flashcards

1
Q

Monomer Binding proteins

A

Regulate filament formation by limiting or promoting use of pool of monomers. Thymosin & profilin

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2
Q

Thymosin

A

(Monomer binding protein) Bound to G- Actin, prevents elongation from + or - end

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3
Q

Profilin

A

(Monomer binding protein) Competes w/ thymosin for monomer binding. Promotes monomer growth towards + end

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4
Q

Bundling proteins

A

Maintain space between microfilaments that is selective with allowing interaction with other proteins. (Alpha actin, fimbrin, villin)

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5
Q

Fimbrin

A

(Bundling protein) In filopodia at leading edge of crawling cells. Aids in bundling of microfilaments into microvilli.

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6
Q

Villin & Fimbrin

A

Bundle microfilaments into microvilli

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7
Q

Alpha-actinin

A

(Bundling proteins) Z lines of striated muscle, dense bodies of smooth muscle, focal contacts of crawling cells

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8
Q

Cross linking proteins

A

Meshwork of actin filaments (Ex. Filamen)

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9
Q

Filamen

A

(Cross linking proteins) Forms viscous gel by clamping to 2 actin filaments at right angles. Needed for lamelliopodia crawling

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10
Q

Motor Proteins

A

Myosins=ATPases that move actin filament or drag vesicle along actin filament

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11
Q

MF Nucleating proteins

A

Initiate formation of Microfilaments. Arp complex.

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12
Q

Arp complex (Arp 2/3)

A

Nucleate new filament off side of preexisting filament. Forms web to push actin network forward

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13
Q

Severing proteins

A

Regulate length and kinetic behavior. Gelsolin superfamily activated by high [Ca2+]

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14
Q

Capping proteins

A

CapZ and gelsolin bind + ends, limiting growth. Tropomodulin binds - end of thin filaments

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15
Q

Myosin

A

ATPase motor protein that moves actin or exerts force on other cellular structures

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16
Q

Membrane binding proteins

A

Attach filaments to membrane

17
Q

Vinculin

A

@ zonula adherens, attaches to catenin, catenin attaches to E-cadherin… @focal contacts(attachment of crawling cell to ECM), attaches to talin and talin attaches to integrin

Micro Anatomy (3 decks)

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