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Cancer pharmacology PAMS- OSMOSIS > Microtubule inhibitors > Flashcards

Microtubule inhibitors Flashcards

1
Q

What are the classes of drugs in the Microtubule inhibitors category ?

A

Vinka alkaloids and taxens which inhibit mitosis.

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2
Q

What is the structure and function of the cytoskeleton of the cell ?

A

It is a network consisting of actin filaments, intermediate filaments, and microtubules. It gives the cells their shape and anchors organells in place and responsible for conformational changes.

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3
Q

What is the structure of microtubules ?

A

It is a cluster of 13 protofilaments each containing alternating chain of alpha and beta tubulin.

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4
Q

what are the steps of mitosis ?

A
  • Prophase- nuclear membrane disintegration and chromosome condensation occurs.
  • Metaphase- Formation of metaphase plate.
  • Anaphase- centrosome mediated separation of cistocromatides occurs resulting in the formation of mitotic spindle.
  • Telophase- Formation of new nuclear membrane around the each pairs of 46 chromosomes. leading to cytokinesis.
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5
Q

All Microtubule inhibitors are given ______

A

IV

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6
Q

What are the drugs in the vinka alkaloid class of medications ?

A

Vincristine and Vinblastine .

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7
Q

What is the MOA of vinka alkaloids ?

A

They are metaphase specific drugs that bind to beta tubulin and block its polymarization into proto- filaments leading to mitotic arrest at metaphase.

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8
Q

What are the indications for vinka alkaloids ?

A

They are indicated for the Tx of breast cancer, rhabdomyosarcoma, nephroblastoma and leukaemias.

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9
Q

Vincristine and Vinblastine are both indicated for the treatment of both ——– and ————lymphoma.

A

Hodgkins and non-hodgkins.

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10
Q

What are the side effects of vinka alkaloids ?

A

Alopecia, GI symptoms and bone marrow supression. Vincrestine is myelotoxic whereas vinblastine is more neurotoxic.

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11
Q

What are the neurotoxic effects of vinblastine ?

A
  • peripheral neuropathy.
  • Dysautonomia
  • Urinary retention
  • Constipation
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12
Q

What are the drugs belonging to the class of Taxanes?

A

Pacletaxel and Docetaxel.

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13
Q

What is the MOA of Taxanes ?

A

They act by directly hyper-stabilising cistochromatids leading to inhibition of the progression of mitosis from metaphase to anaphase.

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14
Q

What is the indication of Taxanes ?

A

Tx of solid tumours.

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15
Q

What are the side effects of Taxanes ?

A
  • Alopacia
  • Myelosuppression
  • Neurotoxicity.
  • Infusion HSR.
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Cancer pharmacology PAMS- OSMOSIS (9 decks)

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