Microcytic Anaemia

Question 1

where does haemoglobin synthesis occur

Answer 1

in the cytoplasm

Question 2

what does defects in haemoglobin synthesis cause

Answer 2

small cells

Question 3

what in Hb needed to make

Answer 3

globins

haem-to make porpyrin ring and iron

Question 4

what are hypochromatic, microcytic anaemias caused by

Answer 4

deficient haemoglobin synthesis-cytoplasmic defect

Question 5

what are the 2 sub types of causes of hypochromatic microcytic anaemias

Answer 5

haem deficiency

and globin deficiency

Question 6

what are the causes of haem deficiency

Answer 6

lack of iron for erythropoiesis caused by iron deficiency or anaemia of chronic disease
problems with porphyrin synthesis

Question 7

what is globin deficiency caused by

Answer 7

thalassaemia

Question 8

what is iron needed for

Answer 8

oxygen transport-hb and myoglobin and electron transport

Question 9

what is the potential problem with iron

Answer 9

it is potentially toxic and needs to be handled safely by the body as it generated free radicals