Microbiome and probiotics

Question 1

Probiotics effectiveness

Answer 1

• Probiotics are effective in treating pouchitis, AAD (antibiotic associated diarrhea), C Dif diarrhea, acute (viral) diarrhea, necrotizing enterocolitis, URI
• Mild efficacy in treating atopic dermatitis
• Ulcerative colitis shows conflicting data
• Probiotics should NOT be used in crohns disease (is detrimental)
• Probiotic’s effect on developing immune system is not known, long term safety in children not known

Question 2

Fecal transplant (FMT)

Answer 2

• Only indication so far is recurrent C Dif

- Bacteroides very important to give after C dif infection (bacteroides major commensal bacterium)