Microbiology of Periodontal Disease Flashcards
what’s pathogenicity
the ability of an organism to cause disease
what’s opportunism
a microorganism that can cause infection under certain conditions
what’s a pathbiont microbiota
can cause infection if change in homeostasis
what’s the virulence determinants/factor of a microbiota
component of a pathogen that causes the damage
what’s the evidence that periodontal disease are microbial infections
- animal studies
- human studies
- microbiological studies
- the fact that the treatment is plaque removal
what types of microbiota are present in periodontal health
gram +ve
facultative anaerobes
what types of microbiota are present in periodontal gingivitis
increase in obligate anaerobes
what types of microbiota are present in periodontal disease
gram -ve
anaerobes
spirochetes (spiral)
obligate anaerobes
what’re the 5 steps of microbial pathogenesis
- entry
- attachment
- Multiplication & consolidation
- avoid host defences
- release & spread
what’s the bacterial virulence factor ‘adhesin’
enable binding to host tissue
what’s the bacterial virulence factor ‘invasin’
enables invasion of host cells
what’s the bacterial virulence factor ‘impedin’
enables avoidance of host defence mechanisms
what’s the bacterial virulence factor ‘aggressin’
causes direct damage to host
what’s the bacterial virulence factor ‘modulin’
causes indirect damage to host via overall disturbance of immune system
what are MAMPs
MAMPs are like tiny signals that microbes give off that help us to identify them & protect themselves against threats
What recognises MAMPs
+ whats the immune systems response to them
- recognised by TLR
- receptors identify pathogen
- trigger cascade within cell
- immune cells to site
what’s the immune systems reaction to trichroic/lipoeichodic acid as a MAMP (3)
+what type of bacteria does it effect
adhesion
induction od cytokines
resistance to host defences
gram +ve
what’s the immune systems reaction to peptidoglycan as a MAMP 1)
+what type of bacteria does it effect
- induction of cytokines
gram +ve & gram -ve
what’s the immune systems reaction to lipopolysaccharide as a MAMP (3)
+what type of bacteria does it effect
induction of cytokines
induction of inflammatory response
adhesion
gram -ve
