BIochem Of The PDL 2

Question 1

What’re the 3 ground substances of connective tissue

Answer 1

Glycoproteins
GAGs
Proteoglycans

Question 2

What’re proteoglycans made up of

Answer 2

Protein core + GAGs

Question 3

Proteoglycans in the PDL are _____ rich

Answer 3

Leucine

Question 4

What’s the primary PG in the PDL
+ what’s the other one called

Answer 4

Decorin
+ versican

Question 5

Which GAG is decorin rich in

Answer 5

Dermatan sulphate (DS)

Question 6

What’s the function of decorin

Answer 6

‘Decorate’ collagen fibres

Question 7

Which GAG is versican rich in

Answer 7

Chondroitin sulphate (CS)

Question 8

What’s the size of:
- decorin
- versican

Answer 8

• small PG
• large PG

Question 9

What’re the 3 roles of GAGs in connective tissues

Answer 9

1. Collagen fibril orientation/diameter
2. Control mineralisation
3. Generate eruptive force

Question 10

Dermatan sulphate rich PGs are associated with _______ diameter collagen fibres in _______ tissues

Answer 10

1. Large
2. Mature

Question 11

Chondroitin sulphate rich PGs are associated with _______ diameter collagen fibres in _______ tissues

Answer 11

1. Small
2. Foetal

Question 12

What’s the role of GAGs on mineralisation

Answer 12

GAGs inhibit deposition of hydroxyapatite in PDL

Question 13

what would happen if GAGs were removed in the PDL

Answer 13

Deposition of hydroxyapatite

Question 14

How to GAGs generate eruptive force

Answer 14

Highly charged
V. Hydrophilic (attract water molecules enough to generate hydrodynamic force)

Question 15

What happens to the following in PDL disease:
- GAG poph
- % DS (therefore…..)
- % CS (therefore…..)
- collagen content
- gelatinase activity

Answer 15

• GAG poph increases
• % DS decreases (decorin decreases)
• % CS increases (versican increases)
• collagen content decreases
• gelatinase activity increases