Microbiology Lecture Flashcards
Normal CSF values
White cells
Clinical presentation of viral meningitis
Headache
Fever
Neck stiffness
Photophobia
Lumbar puncture for viral meningitis should show…
WCC raised, predominantly lymphocytes
Protein normal or slightly raised
Glucose normal
What should you do to investigate for viral meningitis other than lumbar puncture CSF values?
Send for enterovirus PCR
Could do stool sample
Organisms which cause neonatal meningitis (3)
Group B Streptococcus
E.coli
Listeria monocytogenes
Describe the acquiring of Group B streptococcus neonatal meningitis
Occurs within the first few days after birth, acquired from mother, vaginal colonisation
Treatment for Group B streptococcal meningitis in neonates
Benzylpenicillin and gentamycin
Prevention of Group B Streptococcal meningitis in neonates
Intrapartum antibiotics
When do we give intrapartum antibiotics for group b neonatal strep meningitis prophylaxis (5)
Pre-term labour Prolonged rupture of membranes Found incidentally to have GBS in vagina or urine Fever in labour /amnionitis GBS infection in a previous baby
Treatment for neonatal meningitis caused by E.Coli
Cefotaxime and gentamycin
amoxicillin if susceptible
How do babies acquire listeria monocytogenes meningitis?
Transplacental - causes stillbirth as well as neonatal sepsis/meningitis
Found in various foods eg soft cheese and pate
Treatment for listeria monocytogenes meningitis in neonates
Amoxicillin and gentamycin
Clinical features of brain abscess
Classic triad of fever headache and focal neurological signs
Can have seizures
Organisms causing brain abscess
Streptococci, particularly S.milleri Coliforms e.g Proteus sp Anaerobes Staphylococcus aureus Actinomyces sp
How do we diagnose a brain abscess
CT Brain with contrast
