Microbio- zoonoses + prion disease Flashcards

1
Q

Definition of zoonoses?

A

Infections acquired from vertebrate animals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

3 infections from rats?

A

Rabies, plague, Hantan viruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

5 infections from cats

A

Bartonellosis, Salmonella, Rabies, Q-fever, Toxoplasmosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

5 infections from dogs

A

Hydatid disease, salmonella, rabies, leptospirosis, ringworm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Small ruminants - 3 infections?

A

Brucellosis, anthrax, Listeria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

5 infections from cattle?

A

Toxoplasmosis, bovine TB, E coli 0157, anthrax, brucellosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

4 infections from birds

A

Psittacosis
Influenza A
West Nile virus
cryptococcus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

3 infections - Water sports associated

A

Leptospirosis
Hep A
Giardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Brucella - what kinda bacteria is it? How is ti transmitted? Which animals?

A

Gram -ve aerobic bacilli
Facultative intracellular

Transmitted by consumption of untreated dairy.
RUMINANTS + PIGS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Undulant fever, spinal tenderness, lymphadenopathy, hepatosplenomegaly +consumption of shit dairy

A

Brucellosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Serology results +ve for brucellosis?

A

anti-O-polysaccharide antibody

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Treatment of brucellosis

A

Tetracycline or doxycycline, combined with streptomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Negri bodies

A

Rabies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Rabies - serology? Treatment?

A

ELISA for specific IgM, or RT-PCR

Rabies IgG post-exposure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Plague - what is the bacteria involved?

How is it transmitted?

A

Bacteria = Yersinia Pestis

In rats, transmitted by fleas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Ingestion of unpasteurised milk –> fever which comes and goes + back pain.

Dx? Ix? Tx?

A

Dx: Brucellosis
Ix: - anti-O-polysaccharide antibody
Tx: - Tetracycline + streptomycin

17
Q

Which zoonosis is excreted in dog/rat urine?

A

Leptospirosis

18
Q

Painless round black lesions + rim of oedema

A

Cutaneous anthrax

19
Q

Rash seen in Lyme disease?

A

Erythema chronicum migrans

20
Q

Lyme disease: early stage of illness? Late stage of illness?

A

Early stage: flu-like, nerve palsies, arthritis, carditis

Late stage: encephalopathy, arthritis

21
Q

Tx of lyme disease?

A

2-3 weeks of doxy

22
Q

4 types of leishmania disease?

A

Cutaneous
Diffuse cutaenous
Visceral (Kala-Azar)
Mucocutaneous

23
Q

Diff between lesions seen in diffuse cutaneous vs mucocutaneous leishmaniasis

A

Diffuse cutaneous: NO ULCERS

Mucocutaneous: ulcers in mouth/nose (mucus membranes)

24
Q

Vector of leishmaniasis?

25
Prion disease - on which chromosome is the prion protein gene? which codon is important?
Chromosome 20 | Codon 129
26
which polymorphism is most associated with prion disease?
MM on codon 129
27
Most common form of prion disease?
Sporadic CJD
28
Disease course of sporadic CJD?
Rapidly progressive ataxia + amnesia + myoclonic jerks + LMN signs. Death in 6 months
29
Post mortem findings in sporadic CJD - give 2
- PrP amyloid plaques | - Spongiform vacuolation
30
In what form of CJD is tonsillar biopsy super useful?
Variant CJD | - Tonsillar biopsy is 100% sensitive + specific
31
MRI shows posterior thalamus is highlighted. Which form of CJD is most likely?
variant CJD
32
What polymorphism is seen in all cases of variant CJD?
MM on codon 129
33
Typical course of symptoms in variant CJD?
Initially PSYCH: anxiety, paranoia, hallucinations | Then, neuro: ataxia, myoclonus
34
WTF is Kuru
Papua New Guinea - exposure to CJD from cannibalistic feasts - Progressive cerebellar syndrome following 45 year incubation period
35
Autosomal dominant inherited condition where insomnia and paranoia leads to hallucinations and weight loss and mutism
Fatal familial insomnia