MicroBio Chapter 13 Flashcards
The invasion or colonization of the body by microorganisms
Infection
Occurs when an infection results in the change of the state of health and when signs and symptoms appear
Disease
True or False
All infections result in disease
False
Exists if two variables appear to be related by a mathematical relationship
Association
Magnitude of one variable appears o move in the opposite direction of the other associated variable
Negative association (Inverse relationship)
Magnitude of both variable move in the same direction
Positive Association (Direct relationship)
The combination of necessary and sufficient factors that results in disease
Casue
A set of 4 criteria to be met before the relationship between a particular infectious agent and a particular disease is accepted as casual.
Koch’s Postulate (1877)
A set of 9 criteria that each contribute a different amount of strength and likelihood that a relationship between a potential risk factor and a disease is casual
Hill’s Criteria of Causation (1965)
Koch’s Postulate
- The microorganism must be present in all the cases of the disease
- The pathogen can be isolated from the host and grown in pure culture
- The pathogen from the pure culture must cause the disease when inoculated into a healthy, susceptible laboratory animal
- The pathogen must be reisolated from the new host and shown to be the same as the originally introduce pathogen
Hill’ Criteria of Causation
S TRENGTH
C ONSISTENCY
S PECIFITY
T EMPORILTY
B IOLOGICAL GRADIENT
P LAUSIBIITY
C OHERENCE
E EXPERMINET
A NALOGY
A small association does not mean there is not a casual effect. Though larger association means more likely casual effect
Strength
This model of disease has 3 components
Epidemiological triad
3 components of epidemiological triad
- External agent
- Components
- Environmental factors
Can be any microorganism that must be present for a disease to occur
Infectious agents
Intrinsic factors that influence an individual’s exposure. i.e age, race, sex
Host Factors
Are extrinsic factors which affect agent and the host and the opportunity of exposure
Environmental factors
Is the passing of a communicable disease from an infected host
Disease transmission
Dynamics of Disease transmission
Source of reservoir - modes of transmission - Susceptible host
The person, animal or object from which an infectious agent passes or is dessimenated to the host
Source