Micro: Viral STIs Flashcards
HPV serotypes that are oncogenic.
16, 18
HPV serotypes that cause genital warts.
6, 11
Name the binding proteins on the oncogenic HPV strains and which gene each binds.
E6 binds p53
E7 binds Rb
Main condition caused by HPV
Condyloma acuminata
-anogenital warts
(remember Condylmoa lata is syphilis)
Cellular feature in those infected with HPV.
Koilocytic Change: perinuclear cytoplasmic vacuole formation
Positive Tzanck smear test.
HSV or VZV
-Tzanck cells are multi-nucleated giant cells seen on microscopy. They are fused skin cells scraped from herpes or chicken pox lesions
Tx and MOA of treatment for Herpes infection.
Acyclovir
-drug is converted into a nucleoside analog by viral thymidine kinase and incorporates itself to inhibit viral DNAP from replicating viral DNA
Causative Agent of molluscum contagiosum.
Poxviruses
Fusion protein on HIV.
Gp41 (transmembrane protein)
Surface protein on HIV that binds CD4 on T cells.
Gp120 (envelope antigen)
Protein that allows early detection of an HIV infection.
p24 capsid
Abs against this protein are detected in screening tests
HIV protein that, if mutated, allows for infection but NOT virulence.
nef protein
Co-receptor required for HIV to bind CD4 on T cells and cause infection.
CCR5
-if this receptor is mutated, HIV cannot infect the host
Why do IgM levels remain high in an HIV infection?
Decrease in CD4 cells prevents class switching in Abs.
Also, lack of proofreading in Reverse Transcriptase allows for many new antigens to be produced and new IgM Abs need to be made.
Screening Test used for HIV.
EILSA
