Micro: Myocarditis/Pericarditis Flashcards
1
Q
mechanism of myocyte injury with coxsackie B
A
- direct damage to myocytes
2
Q
mechanism of myocyte injury with bacterial LPS, viral dsRNA
A
- induces innate immune response of proinflammatory cytokines
3
Q
mechanism of myocyte injury with CMV
A
- induces antibodies that cross react with cardiac myosin
4
Q
mechanism of myocyte injury with diptheria
A
- circulating toxin
5
Q
diagnosis of myocarditis
A
- endomyocardial biopsy
- look for extensive lymphocyte infiltration
6
Q
course of coxsackie B infection
A
- entry to myocyte mediated by cell surface receptors
- once in cell, translation of viral genome occurs
- viral protease 2A cleaves dystrophin which decreases myocyte contractility
7
Q
characteristics of parvovirus B19
A
- erythema infectiosum
- rash appearance - slapped cheek syndrome, maculopapular rash
- myocarditis - replication in myocardial endothelial cells
8
Q
myocarditis caused by diptheria
A
- gram positive rod, toxin producer
- toxin targets myocytes and inhibits elongation factor II
- grey pseudomembrane and bull neck
9
Q
myocarditis caused by borrelia burgdorferi
A
- spirochete carried by Ixodes scapularis tick
- AV block most common manifestation
10
Q
myocarditis caused by lyme disease
A
- damage result of macrophage attacking spirochete
- treatment is IV ceftriaxone or penicillin
11
Q
acute clinical syndrome of T. cruzi myocarditis
A
- chagoma - erythematous and indurated area at site of bug site
- Romana’s sign - rash and edema around eyes and face
- fever, chills, malaise, myalgia, fatigue
- parasites multiply in myocytes
- damage is caused by cell lysis and CMI by activated cytotoxic T cells
12
Q
4 Cs of Trypanosoma cruzi
A
- children
- chagoma
- cardia
- Cruzi
13
Q
treatment of T. cruzi
A
- nifurtimox
14
Q
presentation of infectious pericarditis
A
- pleuritic chest pain
- high fever
- pericardial friction rub
- EKG abnormalities
