Micribial Invasion Flashcards
What are the physical barriers preventing microbial invasion?
Tears Turbulence Saliva Vomiting Cilia Dessication Lysozyme Diarrhea Gastric pH
What are the functions of cells of innate immunity?
Detect invaders
Eat invaders
Kill invaders
Kill virus-infected cells
What are the functions of molecules of innate immunity?
Bind and kill invaders
Coat invaders so cells can kill them
Block microbial growth
Prevent microbial spread
Mobilize body defenses
Describe antibody-mediated immune response
Immunity can be transferred artificially - injection of immune serum
Immunity can be transferred naturally - Mother’s Milk
Second dose of antigen stimulates a specific immune response
What is serum?
A cell free liquid, minus clotting factors
What is plasma?
Cell free liquid with clotting factors in solution (must add an anticoagulant)
What are the general characteristics of innate immunity?
Antibody-mediated immune response
Phagocytes
Natural killer cells
Blood components
Hours
What are the general characteristics of adaptive immunity?
T and B cells
Recent evolutionary history
Slow onset (days-week)
Unique antigens (Ag)
Rarely overwhelmed
Significant memory
Improves with exposure
Mechanisms
- Extracellular
- Intracellular
Generation of specific receptors
Days, weeksExplain the extracellular mechanisms
Antigen-processing cells
Antigen-sensitive cells
- Memory cells
- Antibody-producing
- Antibody production
- Antigen elimination
Explain the Intracellular mechanisms
Antigen-processing cells
Antigen-sensitive cells
- Memory cells
- Effector cells
- Cell-mediated immunity
- Antigen elimination
Explain microbial invasion
Invading microorganism -> physical barriers -> innate immunity -> specific immunity
