MI timeline Flashcards
1
Q
4-12 hours
A
- Histo: Hypereosinophilia of myocytes
- Clinical: Elevated Troponin I
2
Q
10-14 days
A
Histo: Definite Granulation tissue w/ collagen fibers Clinical:Dressler Syndrome (Autoimmune-mediated pericarditis)
3
Q
3-7 Days
A
- Histo: Dying PMNs, Macrophages enter
- Clinical: Rupture of Free wall, ventricular septum, or papillary muscle
- Gross: Tissue is soft and appears yellow with red border due to hyperemia
4
Q
12-24 hours
A
- Histo: Coagulation Necrosis, w/ possibly PMNs
- Clinical: Serious arrhythmias *Gross: Red-blue discoloration
5
Q
1.5 to 4 hours
A
*Irreversible injury
- Histo: Wavy Fibers and Contraction Bands
- Clinical: Mural Thrombi
6
Q
2-8 Weeks
A
- Histo: Increased collagen and decreasked cellularity. Dense scar as early as 6 weeks
- Clinical: Ventricular aneurysms (Late complications)
- Gross: White, fibrous scar.
7
Q
1-3 Days
A
- Histo: Coagulation necrosis, PMNs peak at 48 hours
- Clinical: Pericardial Friction rub (due to Fibrinous pericarditis caused by PMNs)
8
Q
7-10 Days
A
- Histo: Early granulation tissue w/ proliferation of blood vessels
- Clinical: N/A
