MHRA warnings

Question 1

GENTAMICIN

Answer 1

• Ototoxicity
• Nephrotoxicity

Question 2

NITROFURANTOIN

Answer 2

• Pulmonary events
• Hepatic events

Cautions:
* Caution in renal impairment (eGFR <45)
* May discolour urine yellow/ brown

Question 3

QUINOLONES

Answer 3

• Suicidal beaviours and thoughts
• Qt prolonation/ aortic anyeurism/ heart valve regurgitation
• Use only if no other appropriate options available
• Increases risk of seizures (taking NSAIDs at the same time may also induce convulsions)
• Neuroloical effects/ peripheral neuropathy
• Tendon rupture/ tendonitis
• Sun sensitivity

Question 4

TETRACYCLINES

Answer 4

• Benign intracranial hypertension (STOP & report on headache/ visual disturbance)
• Teeth discolouration & bone deposit (don’t give to children under 12 & prenant women)
• Hepatotoxicity
• Photosensitivity

Question 5

CORTICOSTEROIDS

Answer 5

• Give a steroid card (if they are receiving long-term treatment (more than 4 weeks) and/or high doses
• Central serous chorioretinopathy

Question 6

SGLT2i

Answer 6

• Life-threatenin DKA!
  Monitor ketones if treatment is interrupted (surgery/ illness)
• Fournier’s gangrene

Question 7

BISPHOSPHONATES

Answer 7

• Atypical femoral fractures
• Ostenecrosis of the jaw
• Osteonecrosis of the external auditory canal

Question 8

CARBIMAZOLE

Answer 8

• Neutropenia and agranulocytosis- report sore throat, malaise, fever
• Congenital malformations- women should use effective contraception
• Acute pancreatitis- stop immediately and permanently if pancreatitis occurs