MG

Question 1

Def

Answer 1

Autoimmune disease. There’s formation of autoantibodies against post synaptic AC receptors at the skeletal muscles (NMJ)

Question 2

Types

Answer 2

1) Juvenile MG
2) Transient neonatal MG
3) Congenital MG

Question 3

Juvenile MG

Answer 3

• Autoimmune
• Female adolescent
• Difficulties in chewing and swallowing
• eyelid drop

Question 4

Transient neonatal MG

Answer 4

The antibodies are from the mother
Baby with weak cry,poor suckling and respiratory difficulties
Syx fades within weeks

Question 5

Congenital MG

Answer 5

Autosomal recessive 
Begin in 1st year of life then life long
Generalised weakness in arms and legs
Delayed motor skills 
Difficulties in feeding

Question 6

Dx:

Answer 6

Tensilone test
EMG
Nerve conduction study
Muscle biopsy to confirm the dx

Question 7

Tx:

Answer 7

Aim: prevent respiratory problems and provide adequate nutrition

1-Cholinesterase inhibitors: as Pyridostigmine bromide
2-High dose IV immune globuline.
3-Plasmapheresis