METROTEXATE Flashcards

gota

1
Q

mecanismo de accion

A

antagonista del acido folico
inhibe dihidrofolato reductsa
inhibe la sint. adn y divicion celular
inhibe los precursores de la inflamacion

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2
Q

cinetica

A

im,iv,vo
met hepatico
amplia distribucion
no atraviesa la bhe
eliminacion renal

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3
Q

indicacion

A

les
cancer mama
artitis reuma
sarcomas

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4
Q

efectos adversoso

A

depresion medular
fatiga
neumonits
teratogenico
alopecia

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5
Q

contraindicaciones

A

embarazo
insuficiencia renal
insuficiencia hepatica
mielo supreson

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6
Q

interacion

A

aines
atb
acido folico
alchool

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