Methylprednisolone (Solu-Medrol)

Question 1

Methylprednisolone (Solu-Medrol)
Classification

Answer 1

Corticosteroid
Anti-inflammatory

Question 2

Methylprednisolone (Solu-Medrol)
Mechanism of Action

Answer 2

Diffuses across the cell membrane of various cells present in all tissues, binds to DNA, regulates gene expression and increases synthesis of proteins and enzymes that inhibit inflammatory agents (cytokines, interleukin, interferon); inhibits synthosis of pro-inflammatory enzymes; is an immunosuppressant

Question 3

Methylprednisolone (Solu-Medrol)
Onset of Action

Answer 3

2-6 hrs

Question 4

Methylprednisolone (Solu-Medrol)
Peak Effects

Answer 4

4-8 days

Question 5

Methylprednisolone (Solu-Medrol)
Duration of Effect

Answer 5

1-5 weeks

Question 6

Methylprednisolone (Solu-Medrol)
Half-life

Answer 6

3.5 hrs

Question 7

Methylprednisolone (Solu-Medrol)
Indications/Field Use

Answer 7

Allergic reaction/anaphylaxis
Asthma, COPD

Question 8

Methylprednisolone (Solu-Medrol)
Contraindications

Answer 8

Hypersensitivity

Question 9

Methylprednisolone (Solu-Medrol)
Side Effects/Adverse Reactions

Answer 9

Fluid retension
CHF
HTN
Abdominal distension
Vertigo
HA
Nausea
Malaise
Hiccups

Question 10

Methylprednisolone (Solu-Medrol)
Adult Dose

Answer 10

125mg slow IV/IO

Question 11

Methylprednisolone (Solu-Medrol)
Pedi Dose

Answer 11

2mg/kg slow IV/IO (max dose 125mg)

Question 12

Methylprednisolone (Solu-Medrol)
Precautions

Answer 12

Give only one dose prehospitally, long-term steroid use can cause GI bleeding, prolonged wound healing, and suppression of adrenocortical steroids